Dropping pills containing Prunella vulgaris extract and preparation method thereof

A technology of Prunella vulgaris and its extract is applied to dropping pills containing Prunella vulgaris extract. The field of preparation of the dropping pills can solve the problems such as no disclosure of Prunella vulgaris extract preparations.

Active Publication Date: 2020-10-02
BEIJING UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This document also does not disclose the preparation of Prunella vulgaris extract

Method used

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  • Dropping pills containing Prunella vulgaris extract and preparation method thereof
  • Dropping pills containing Prunella vulgaris extract and preparation method thereof
  • Dropping pills containing Prunella vulgaris extract and preparation method thereof

Examples

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Effect test

preparation example 1

[0052] Preparation example 1-Prunella vulgaris extract A

[0053] The preparation method of the Prunella vulgaris extract of the present invention is:

[0054] (1) Extract Prunella vulgaris with water as the extraction solvent, heat reflux and extract twice, add 10 times the amount of water to extract for 1 hour each time, combine the extracts, concentrate the extracts under reduced pressure, and dry to obtain a crude extract of Prunella vulgaris.

[0055] (2) Disperse the crude extract of Prunella vulgaris in deionized water to obtain a loading solution with a crude extract content of 31g / 100ml of Prunella vulgaris. Place the loading solution on an AB-8 macroporous resin column, and use 2 One-fold volume of deionized water, three-fold volume of 20 vol% ethanol aqueous solution and five-fold volume of 50 vol% ethanol aqueous solution were used as eluents for gradient elution.

[0056] (3) Collect the eluate eluted with 50 vol% ethanol aqueous solution, concentrate and dry to obtain Pr...

preparation example 2

[0057] Preparation example 2-Prunella vulgaris extract B

[0058] (1) Prunella vulgaris was extracted by ultrasonic method with 70vol% ethanol aqueous solution as the extraction solvent, ultrasonically extracted twice at 45℃, each time 20 times the amount of ethanol aqueous solution was added for 1 hour, the extracts were combined, concentrated under reduced pressure until there was no alcohol, and dried , To obtain the crude extract of Prunella vulgaris.

[0059] (2) Disperse the crude extract of Prunella vulgaris in water to obtain a loading solution with a crude extract content of 31g / 100ml of Prunella vulgaris. Place the loading solution on an AB-8 macroporous resin column and use 2 times the volume in turn. Deionized water, 3 times volume of 20 vol% ethanol aqueous solution and 5 times volume of 70 vol% ethanol aqueous solution were used as eluents for gradient elution.

[0060] (3) Collect the eluate eluted with 70 vol% ethanol aqueous solution, concentrate the eluate, and dr...

preparation example 3

[0062] (1) Extract Prunella vulgaris with water as the extraction solvent, ultrasonically extract 3 times, ultrasonic temperature 35℃, add 10 times the amount of water to extract for 1.5h each time, combine the extracts, concentrate the extracts under reduced pressure, and dry to obtain crude extracts of Prunella vulgaris ;

[0063] (2) Disperse the crude extract of Prunella vulgaris in deionized water to obtain a sample loading solution with a crude extract content of 50g / 100ml of Prunella vulgaris. Place the sample loading solution on an AB-8 macroporous resin column, and then Use 4 times volume of deionized water, 2 times volume of 15 vol% ethanol aqueous solution and 5 times volume of 60 vol% ethanol aqueous solution as eluents for gradient elution;

[0064] (3) Collect the eluate after elution with 60 vol% ethanol aqueous solution, concentrate and dry to obtain Prunella vulgaris extract.

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Abstract

The invention discloses dropping pills containing a spica prunellae extract. The dropping pills comprise the spica prunellae extract and a matrix, wherein the spica prunellae extract is obtained through the following steps: spica prunellae is extracted with water or an ethanol aqueous solution as an extraction solvent, and a crude spica prunellae extract is obtained; the crude spica prunellae extract is loaded on a macroporous resin column and sequentially subjected to gradient elution with water, 10vol%-30vol% of an ethanol aqueous solution and 50vol%-95vol% of an ethanol aqueous solution; aneluate obtained after elution with 50vol%-95vol% of the ethanol aqueous solution is concentrated and dried, and the dropping pills are obtained. The dropping pills containing the spica prunellae extract have significant ahypnia prevention and treatment effects.

Description

Technical field [0001] The invention relates to a dripping pill with sedative and hypnotic effects, in particular a dripping pill containing prunella vulgaris extract, and a preparation method of the dripping pill. Background technique [0002] Insomnia refers to a subjective experience in which the patient is not satisfied with the sleep time and / or quality and affects daytime social functions. Clinical intervention methods for insomnia are divided into non-drug treatment and drug treatment. Western medicine is the main drug treatment. However, the main purpose of most drugs is not to treat insomnia. Long-term use of sleeping pills may cause adverse reactions such as drowsiness, forgetfulness, and allergies, and even develop tolerance and addiction, which can aggravate insomnia symptoms and induce insomnia. Depression, etc. People pay more and more attention to the therapeutic effect of Chinese medicine on insomnia. [0003] Insomnia is called insomnia, insomnia, insomnia, inso...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K36/536A61P25/20
CPCA61K9/006A61K9/2031A61K36/536A61K2236/331A61K2236/333A61K2236/39A61K2236/55
Inventor 王庆国王雪茜屈会化程发峰赵琰孔慧魏震孙良明
Owner BEIJING UNIV OF CHINESE MEDICINE
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