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A kind of medical titanium mesh with tissue engineering stent coating and preparation method thereof

A tissue engineering scaffold, titanium mesh technology, applied in the field of medical devices, can solve problems such as inflammation, scarring, affecting soft tissue repair, etc.

Active Publication Date: 2021-10-15
BEIJING YH BIOMAX BIOLOGIC TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Since bone tissue usually grows adjacent to connective tissue, muscle tissue, etc., bone tissue defects are often accompanied by damage to the surrounding soft tissue, and simply repairing or replacing the defective bone tissue with titanium mesh without repairing or protecting the surrounding soft tissue will affect the quality of the bone tissue. Repair of soft tissue, and even cause adverse reactions such as inflammation and scarring

Method used

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  • A kind of medical titanium mesh with tissue engineering stent coating and preparation method thereof
  • A kind of medical titanium mesh with tissue engineering stent coating and preparation method thereof
  • A kind of medical titanium mesh with tissue engineering stent coating and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1: Skull Replacement - Medical Titanium Mesh with Bilateral Tissue Engineering Stent Covering

[0025] Type I collagen was swelled in hydrochloric acid at pH 4, and homogenized using a disperser to obtain a slurry with a concentration of 0.5%. Use a vacuum pump to pump the homogeneous slurry to remove air bubbles in the slurry. Fix the commercially available medical titanium mesh in the freeze-drying mold, pour the pumped slurry into the freeze-drying mold, and shake the mold to make the slurry fully and evenly contact with both sides of the medical titanium mesh and the freeze-drying mold. The freeze-drying mold loaded with medical titanium mesh and slurry is sent to a freeze dryer, and the moisture in the slurry is removed by freeze-drying, so that the dried and formed type I collagen tissue engineering scaffold coating is tightly combined with the medical titanium mesh. The freeze-drying parameters are: pre-freezing temperature 0°C, holding time 50min, norma...

Embodiment 2

[0027] Example 2: Maxillofacial Fracture Repair - Medical Titanium Mesh with Unilateral Tissue Engineering Stent Covering

[0028] Type I collagen was swollen in lactic acid at pH 3.5, and homogenized using a disperser to obtain a slurry with a concentration of 0.4%. Use a vacuum pump to pump the homogeneous slurry to remove air bubbles in the slurry. Fix the commercially available medical titanium mesh in the freeze-drying mold, pour the pumped slurry into the freeze-drying mold, and shake the mold to make the slurry fully and evenly contact with one side of the medical titanium mesh and the freeze-drying mold. The freeze-drying mold loaded with medical titanium mesh and slurry is sent to a freeze dryer, and the moisture in the slurry is removed by freeze-drying, so that the dried and formed type I collagen tissue engineering scaffold coating is tightly combined with the medical titanium mesh. Freeze-drying parameters are: pre-freezing temperature -5°C, holding time 100min, ...

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Abstract

The invention relates to a medical titanium mesh with tissue engineering stent coating and a preparation method thereof, belonging to the field of medical devices. Medical titanium mesh is a medical device used for the repair of human bone tissue. The tissue engineering scaffold on it is covered with type I collagen material, which has a three-dimensional pore structure, which can realize the repair and regeneration of soft tissue injuries. The medical titanium mesh and tissue engineering scaffold cover are combined by freeze-drying method. The medical titanium mesh is coated on one or both sides, and the coating has a certain thickness. There is a certain distance of uncoated area on the edge of the titanium mesh, so that the medical titanium mesh can be easily fixed on the bone tissue defect of the human body. The tissue engineering stent coating and the medical titanium mesh are physically combined, and the coating process does not change the original functions of the two. The medical titanium mesh with the tissue engineering scaffold coating can be used for the repair and replacement of bone tissue defects in contact with soft tissues in the human body.

Description

technical field [0001] The patent of the present invention relates to a medical titanium mesh covered with a tissue engineering stent and a preparation method thereof, belonging to the field of medical devices, and relates to a covered medical titanium mesh, which is used for bone tissue repair and replacement in contact with soft tissues of the human body. Background technique [0002] Medical titanium mesh is a medical device material with good biocompatibility and corrosion resistance, and it is widely used in the field of bone tissue repair and replacement. Medical titanium mesh has many advantages in the application of related orthopedic diseases such as skull defect repair, limb bone defect reconstruction, large chest wall defect repair, metacarpophalangeal fractures, and maxillofacial fractures. Pores and scaffolds grow rapidly, and the interconnected multi-directional micropores inside produce capillary permeation. The elastic modulus of this metal implant material ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/06A61L27/34A61L27/50A61L27/56
CPCA61L27/06A61L27/34A61L27/50A61L27/56A61L2300/412A61L2400/18A61L2420/02A61L2430/02C08L89/00
Inventor 毋晓涛崔蓉蓉王俊华
Owner BEIJING YH BIOMAX BIOLOGIC TECH