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Preparation of amino acid ester type compounds and application thereof in prevention and treatment of tobacco diseases

A technology of ester compounds and amino acids, applied in the chemical field, can solve the problems of no effective prevention and control measures, and achieve the effect of low cost of synthetic raw materials, reasonable synthetic route, and simple operation

Active Publication Date: 2018-05-15
GUIZHOU INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For the prevention and control of the disease, a lot of research has been carried out from the aspects of disease-resistant breeding and improvement of farming system, but there are still no effective prevention and control measures. For this, it is imminent to develop effective drugs against tobacco bacterial wilt

Method used

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  • Preparation of amino acid ester type compounds and application thereof in prevention and treatment of tobacco diseases
  • Preparation of amino acid ester type compounds and application thereof in prevention and treatment of tobacco diseases
  • Preparation of amino acid ester type compounds and application thereof in prevention and treatment of tobacco diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1: target product I 1 Synthesis;

[0030] In a 100mL single-necked bottle, add 4-(dimethoxymethyl)pyrimidin-2-amine (0.001mol), benzaldehyde (0.001mol), diethyl malonate (0.0015mol), 30mL toluene as solvent, Under ultrasonic conditions, heated to 80°C, the reaction was completed for 60 minutes, precipitation, and column chromatography (petroleum ether: ethyl acetate = 5:1 V / V) to obtain the target product.

Embodiment 2

[0031] Embodiment 2: target product I 2 Synthesis;

[0032] In a 100mL single-necked bottle, add 4-(dimethoxymethyl)pyrimidin-2-amine (0.001mol), 4-methoxybenzaldehyde (0.001mol), diethyl malonate (0.0015mol), 30mL of toluene was used as the solvent, heated to 80°C under ultrasonic conditions, and the reaction was completed for 60 minutes. After precipitation, the target product was obtained through column chromatography (petroleum ether:ethyl acetate=5:1V / V).

Embodiment 3

[0033] Embodiment 3: target product I 3 Synthesis;

[0034] In a 100mL single-necked bottle, add 4-(dimethoxymethyl)pyrimidin-2-amine (0.001mol), cyclohexylaldehyde (0.001mol), diethyl malonate (0.0015mol), 30mL toluene as solvent , heated to 80° C. under ultrasonic conditions, the reaction was completed for 60 minutes, and solvent extraction was performed. After column chromatography (petroleum ether: ethyl acetate = 5:1 V / V), the target product was obtained.

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Abstract

The invention discloses preparation methods and biological activity of amino acid ester type compounds containing 4-(dimethoxymethyl)pyrimidine heterocycle for prevention and treatment of tobacco mosaic viruses, namely compounds as shown in the following general formula (I) and preparation methods thereof. The invention introduces amino acid ester type compounds containing 4-(dimethoxymethyl)pyrimidine heterocycle synthesized by a one-pot process under an ultrasonic condition by taking 4-(dimethoxymethyl)pyrimidine-2-amine, substituted aldehyde and malonic ester as raw materials and takes toluene as a solvent. The compounds I5 and I8 disclosed by the invention have better inhibition effects on tobacco mosaic viruses and ralstonia solanacearum. The compounds are shown in the description.

Description

technical field [0001] The invention relates to the field of chemical technology, in particular to an amino acid ester compound containing a 4-(dimethoxymethyl) pyrimidine heterocycle, a preparation method of the compound and its use for preventing and treating tobacco diseases Background technique [0002] Tobacco mosaic disease is a kind of disease that commonly occurs in tobacco cultivation areas all over the world, and it is also an important disease in various tobacco planting areas in my country. Due to the complex transmission and pathogenesis of tobacco mosaic disease, the prevention and treatment of tobacco mosaic disease has become an important issue in agriculture. major problems in production. Tobacco mosaic disease not only seriously affects the yield and quality of tobacco leaves, but also has a serious impact on the appearance quality and internal components of tobacco leaves. Tobacco mosaic disease has become a major obstacle to the high-quality cultivation of...

Claims

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Application Information

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IPC IPC(8): C07D239/42C07D405/12A01N43/54A01P1/00
CPCA01N43/54C07D239/42C07D405/12
Inventor 柏松魏娴朱芸莹吴琴邹树良冯双赵昆红艾丽娜薛婧
Owner GUIZHOU INST OF TECH
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