Preparation of an amino acid ester compound and its use in preventing and treating tobacco diseases

Abstract

The invention discloses a preparation method and biological activity of an amino acid ester compound containing a 4-(dimethoxymethyl)pyrimidine heterocycle, which is a compound for preventing and treating tobacco mosaic virus. It is composed of the following general formula ( I) the compound represented by it and the preparation method thereof. The present invention introduces the use of 4-(dimethoxymethyl)pyrimidin-2-amine, substituted aldehyde, and malonate as raw materials, toluene as solvent, and under ultrasonic conditions, a one-pot synthesis method containing 4-(dimethoxy) Amino acid esters of pyrimidine heterocycles. Compound I of the present invention 5 and I 8 It has good inhibitory effect on tobacco mosaic virus and tobacco bacterial wilt. (I).

Description

technical field

[0001] The invention relates to the field of chemical technology, in particular to an amino acid ester compound containing a 4-(dimethoxymethyl) pyrimidine heterocycle, a preparation method of the compound and its use for preventing and treating tobacco diseases Background technique

[0002] Tobacco mosaic disease is a kind of disease that commonly occurs in tobacco cultivation areas all over the world, and it is also an important disease in various tobacco planting areas in my country. Due to the complex transmission and pathogenesis of tobacco mosaic disease, the prevention and treatment of tobacco mosaic disease has become an important issue in agriculture. major problems in production. Tobacco mosaic disease not only seriously affects the yield and quality of tobacco leaves, but also has a serious impact on the appearance quality and internal components of tobacco leaves. Tobacco mosaic disease has become a major obstacle to the high-quality cultivation of...

Examples

Embodiment 1

[0029] Embodiment 1: target product I 1 Synthesis;

[0030] In a 100mL single-necked bottle, add 4-(dimethoxymethyl)pyrimidin-2-amine (0.001mol), benzaldehyde (0.001mol), diethyl malonate (0.0015mol), 30mL toluene as solvent, Under ultrasonic conditions, heated to 80°C, the reaction was completed for 60 minutes, precipitation, and column chromatography (petroleum ether: ethyl acetate = 5:1 V / V) to obtain the target product.

Embodiment 2

[0031] Embodiment 2: target product I 2 Synthesis;

[0032] In a 100mL single-necked bottle, add 4-(dimethoxymethyl)pyrimidin-2-amine (0.001mol), 4-methoxybenzaldehyde (0.001mol), diethyl malonate (0.0015mol), 30mL of toluene was used as the solvent, heated to 80°C under ultrasonic conditions, and the reaction was completed for 60 minutes. After precipitation, the target product was obtained through column chromatography (petroleum ether:ethyl acetate=5:1V / V).

Embodiment 3

[0033] Embodiment 3: target product I 3 Synthesis;

[0034] In a 100mL single-necked bottle, add 4-(dimethoxymethyl)pyrimidin-2-amine (0.001mol), cyclohexylaldehyde (0.001mol), diethyl malonate (0.0015mol), 30mL toluene as solvent , heated to 80° C. under ultrasonic conditions, the reaction was completed for 60 minutes, and solvent extraction was performed. After column chromatography (petroleum ether: ethyl acetate = 5:1 V / V), the target product was obtained.

technical field

[0001] The invention relates to the field of chemical technology, in particular to an amino acid ester compound containing a 4-(dimethoxymethyl) pyrimidine heterocycle, a preparation method of the compound and its use for preventing and treating tobacco diseases Background technique

[0002] Tobacco mosaic disease is a kind of disease that commonly occurs in tobacco cultivation areas all over the world, and it is also an important disease in various tobacco planting areas in my country. Due to the complex transmission and pathogenesis of tobacco mosaic disease, the prevention and treatment of tobacco mosaic disease has become an important issue in agriculture. major problems in production. Tobacco mosaic disease not only seriously affects the yield and quality of tobacco leaves, but also has a serious impact on the appearance quality and internal components of tobacco leaves. Tobacco mosaic disease has become a major obstacle to the high-quality cultivation of...

Examples

Embodiment 1

[0029] Embodiment 1: target product I 1 Synthesis;

[0030] In a 100mL single-necked bottle, add 4-(dimethoxymethyl)pyrimidin-2-amine (0.001mol), benzaldehyde (0.001mol), diethyl malonate (0.0015mol), 30mL toluene as solvent, Under ultrasonic conditions, heated to 80°C, the reaction was completed for 60 minutes, precipitation, and column chromatography (petroleum ether: ethyl acetate = 5:1 V / V) to obtain the target product.

Embodiment 2

[0031] Embodiment 2: target product I 2 Synthesis;

[0032] In a 100mL single-necked bottle, add 4-(dimethoxymethyl)pyrimidin-2-amine (0.001mol), 4-methoxybenzaldehyde (0.001mol), diethyl malonate (0.0015mol), 30mL of toluene was used as the solvent, heated to 80°C under ultrasonic conditions, and the reaction was completed for 60 minutes. After precipitation, the target product was obtained through column chromatography (petroleum ether:ethyl acetate=5:1V / V).

Embodiment 3

[0033] Embodiment 3: target product I 3 Synthesis;

[0034] In a 100mL single-necked bottle, add 4-(dimethoxymethyl)pyrimidin-2-amine (0.001mol), cyclohexylaldehyde (0.001mol), diethyl malonate (0.0015mol), 30mL toluene as solvent , heated to 80° C. under ultrasonic conditions, the reaction was completed for 60 minutes, and solvent extraction was performed. After column chromatography (petroleum ether: ethyl acetate = 5:1 V / V), the target product was obtained.

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