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Etoricoxib and glucosamine composition

A technology of etoricoxib and composition, applied in the field of pharmacy, can solve the problem of no radical cure of osteoarthritis and the like, and achieve the effects of improved dissolution rate and simple process

Inactive Publication Date: 2018-05-18
WEIHAI GUANBIAO INFORMATION TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is currently no cure for osteoarthritis

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1, etoricoxib 30g crossing 100 mesh sieves, glucosamine hydrochloride 150g, molecular weight is 1.8-2 ten thousand chitosan 15g, microcrystalline cellulose 60g, lactose 20g, croscarmellose sodium 8g, Sodium lauryl sulfate 1.3g, magnesium stearate 1.2g, prepare 1000 tablets by the preparation method described in the technical scheme.

Embodiment 2

[0023] Embodiment 2, etoricoxib 60g crossing a 100 mesh sieve, 80g of glucosamine hydrochloride, 26g of chitosan with a molecular weight of 18,000-20,000, microcrystalline cellulose 30g, lactose 40g, croscarmellose sodium 15g, Sodium lauryl sulfate 1.8g, magnesium stearate 1.7g, prepare 1000 tablets by the preparation method described in the technical scheme.

Embodiment 3

[0024] Embodiment 3, 40g of etoricoxib crossing 100 mesh sieves, 120g of glucosamine hydrochloride, 22g of chitosan with a molecular weight of 1.8-20,000, 52g of microcrystalline cellulose, 35g of lactose, 12g of croscarmellose sodium, Sodium lauryl sulfate 1.5g, magnesium stearate 1.5g, prepare 1000 tablets by the preparation method described in the technical scheme.

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PUM

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Abstract

The invention relates to an etoricoxib and glucosamine composition, and belongs to the technical field of pharmacy. By means of the technical scheme, in the unit dosage of composition, 30-60 mg of etoricoxib passing through a 100-mesh sieve, 80-150 mg of glucosamine hydrochloride, 15-26 mg of chitosan with the molecular weight of 18-20 thousand, 30-60 mg of microcrystalline cellulose, 20-40 mg oflactose, 8-15 mg of croscarmellose sodium, 1.3-1.8 mg of lauryl sodium sulfate and 1.2-1.7 mg of magnesium stearate are contained. By means of the etoricoxib and glucosamine composition, the inflammation eliminating and pain relieving functions of etoricoxib and the cartilage repairing and maintaining functions of glucosamine hydrochloride are ingeniously combined, and an unexpected synergistic effect is generated.

Description

technical field [0001] The invention relates to an etoricoxib composition and belongs to the technical field of pharmacy. Background technique [0002] Osteoarthritis is a non-inflammatory degenerative joint disease characterized by joint pain and stiffness, especially after prolonged activity. Occurs more frequently in people over the age of 50, more women than men, and this disease seriously affects the quality of life of middle-aged and elderly patients. The main pathological changes of osteoarthritis are the degeneration and disappearance of cartilage, and the formation of osteophytes at the attachment of ligaments at the joint margin and the reactive hyperplasia of subchondral bone, which cause joint pain, stiffness, deformity and dysfunction. There is currently no cure for osteoarthritis. Long-term osteoarthritis will cause continuous degeneration and wear of articular cartilage, presenting a bad cycle. Patients with severe knee arthritis can't even walk and lose the...

Claims

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Application Information

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IPC IPC(8): A61K31/7008A61K31/444A61K9/20A61K47/36A61K47/20A61P29/00A61P19/02
CPCA61K31/7008A61K9/2013A61K9/205A61K31/444A61K2300/00
Inventor 孙爱梅
Owner WEIHAI GUANBIAO INFORMATION TECH
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