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Hydrogel containing venom polypeptide and eye treatment mask prepared with hydrogel

A technology of snake venom polypeptide and hydrogel, which is applied in the direction of medical preparations containing active ingredients, skin care preparations, cosmetic preparations, etc., can solve problems such as decomposition and destruction, and achieve the effects of firming skin and improving fine lines. Effect

Inactive Publication Date: 2018-05-29
GUANGZHOUJIDABIOLOGICAL TECH CO LTD +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the prepared hydrogel also effectively solves the problem that snake venom polypeptides are easily decomposed and destroyed by oxidants, reducing agents, proteolytic enzymes, etc., so as to obtain sustainable release of effective active ingredients and significantly improve the effect of eye masks on reducing fine lines. , skin firming and eye mask to improve eye bags and dark circles

Method used

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  • Hydrogel containing venom polypeptide and eye treatment mask prepared with hydrogel
  • Hydrogel containing venom polypeptide and eye treatment mask prepared with hydrogel
  • Hydrogel containing venom polypeptide and eye treatment mask prepared with hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] Example 1. Extraction of "snake venom polypeptide" that can be used in the present invention from crude snake venom polypeptide

[0065] The method of further extracting the "snake venom polypeptide" that can be used in the present invention from the crude snake venom polypeptide is a conventional method. For example, a possible extraction method includes the following steps:

[0066] (1) Take 1 g of crude snake venom and dissolve it with 10 ml of 0.01M ammonium acetate buffer, and centrifuge at 2000 rpm / min for 10 min to get the supernatant;

[0067] (2) adding the supernatant obtained in step (1) to a CM-Agrose cation exchange column equilibrated with 0.01M ammonium acetate buffer, and eluting with the buffer;

[0068] (3) Use 0.05-1.5M sodium chloride-ammonium acetate buffer as gradient elution, flow rate 0.5ml / min, detect with ultraviolet detector, collect main protein peaks, freeze-dry to obtain sample A:

[0069] (4) equilibrate the Sephadex G-50 gel column with...

Embodiment 2

[0076] Example 2. Preparation of hydrogels comprising snake venom polypeptides

[0077] This example provides a method for preparing a hydrogel containing snake venom polypeptides.

[0078] In the final hydrogel containing snake venom polypeptides, the mass percentages of each component are shown in Table 1 below:

[0079] Table 1. The mass percent of each component in the finally prepared hydrogel comprising snake venom polypeptide

[0080]

[0081]

[0082] Those skilled in the art should understand that in the following operation steps, the actual amount or the amount ratio of each component can be based on the production scale according to the mass percentage of each component in the hydrogel containing the snake venom polypeptide shown in Table 1 (ie, the actual formulated hydrogel weight) was adjusted proportionally. This is within the ability of those skilled in the art.

[0083] The "snake venom polypeptide" used in this example was purchased from Chengdu Yunx...

Embodiment 3

[0091] Example 3. Preparation of repair eye mask comprising snake venom polypeptide

[0092] The invention provides a method for preparing eye repair mask containing snake venom polypeptide.

[0093] Continuation of Example 2, Step 8: Spread the hydrogel containing snake venom polypeptide prepared in Step 7 evenly on the non-woven fabric, cover with lining, dry at 40°C for 3 hours, cut and seal to obtain the snake venom polypeptide eye mask.

[0094] Those skilled in the art should understand that in the finally prepared eye repair mask, the mass percentage of each component is actually equal to the mass percentage of each component in the hydrogel containing snake venom polypeptide prepared in step 7.

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PUM

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Abstract

The invention relates to a hydrogel prepared by taking venom polypeptide as a core active component and an eye mask prepared with the hydrogel. The hydrogel is prepared from active components containing venom polypeptide, plant extractive nano microcapsule and the like, and the hydrogel is used to prepare eye treatment masks and other cosmetics and skincare product. The venom polypeptide is protected by a hydrogel mesh-shaped supporting structure, and thus the problem that the venom polypeptide is easily decomposed and damaged by oxidants, reducing agents, proteolytic enzymes and the like canbe effectively solved; in addition, oat kernel extractive, Chrysanthellum indicum extractive and other extractives are packed in a capsule material of nano microcapsules to obtain light-colored transparent nano microcapsule suspension; the problems such as 'brown, yellow, black' color of the preparation are solved, and effective active components are sustainably released through the controlled release effect of the hydrogel, and the effects of the eye mask, such as reducing fine lines, firming skin and improving pouch and black eye are significantly improved.

Description

technical field [0001] The invention belongs to the field of cosmetics. Specifically, the present invention relates to a hydrogel prepared with snake venom polypeptide as the core active ingredient and a repairing eye mask prepared with the hydrogel. The invention effectively solves the problems that snake venom polypeptides are easily decomposed and destroyed by oxidants, reducing agents, proteolytic enzymes, etc., and the color of plant extract preparations such as oat kernel extract is "earth, yellow, black" and the like. The effective active ingredients are continuously released to significantly improve the effects of the eye mask on reducing fine lines, tightening the skin, and improving bags under the eyes and dark circles. Background technique [0002] The transdermal drug delivery system, also known as the transdermal therapeutic system, refers to a drug delivery method in which the drug is absorbed through the skin through capillaries at a certain rate and enters t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9794A61K8/9789A61K8/04A61K8/11A61K8/34A61K8/49A61K8/64A61K8/67A61Q19/00A61Q19/08
CPCA61K8/042A61K8/11A61K8/34A61K8/4946A61K8/64A61K8/673A61K8/97A61K2800/56A61K2800/5922A61Q19/005A61Q19/08
Inventor 黄亚东项琪肖巧学薛来武祝玮勇石磊
Owner GUANGZHOUJIDABIOLOGICAL TECH CO LTD
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