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Markers for subclinical pelvic inflammation disease and applications thereof

A technique for pelvic inflammatory disease, disease, applied in the field of application in detection of subclinical pelvic inflammatory disease

Active Publication Date: 2018-06-01
湖南省妇幼保健院
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are currently no sensitive and specific biomarkers for the diagnosis of subclinical PID [10]

Method used

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  • Markers for subclinical pelvic inflammation disease and applications thereof
  • Markers for subclinical pelvic inflammation disease and applications thereof
  • Markers for subclinical pelvic inflammation disease and applications thereof

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Experimental program
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Embodiment Construction

[0047] patient information

[0048] This study passed the review of the Ethics Committee of Hunan Maternal and Child Health Hospital and met the requirements of the Declaration of Helsinki. All subjects signed an informed consent form before starting the experiment. Both subclinical pelvic inflammatory disease and healthy subjects were female, aged 20-30, with a body mass index of 18.5-23.5, respectively, from the Gynecology and Physical Examination Center of Hunan Maternal and Child Health Hospital from 2016 to 2017. All subjects are from Hunan, Jiangxi, Guangdong, Guangxi.

[0049] The patients with subclinical pelvic inflammatory disease enrolled in the group had C-reactive protein and erythrocyte sedimentation rate within the normal range, without obvious symptoms of pelvic inflammatory disease, but showed infertility. Their pelvic inflammatory disease was confirmed by laparoscopy / hysteroscopy. Patients with acute pelvic inflammatory disease, endometriosis, uterine fi...

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Abstract

The invention belongs to the technical field of biology, and relates to a series of metabolites for diagnosis of subclinical pelvic inflammation disease. A metabonomic method based on liquid chromatogram-mass spectrometry is used for systematically screening metabolites in blood, in order to find metabolites which have obvious correlation to existence of generation of subclinical pelvic inflammation disease as biomarkers of the disease. The metabolites comprise the following components: lysobisphosphatidic acids 16:0 / 0:0, ceramide-1-phosphate d18:1 / 16:0, stearamide, linoleic acid, stearic acid, phosphatidylethanol P-18:0 / 0:0, phosphatidyl ethanolamine P-18:0 / 0:0, lysobisphosphatidyl ethanolamine P-20:0 / 0:0, indoxylsulfuric acid, 3-indolepropionic acid, and p-methylphenol. The biomarkers are used for noninvasive diagnosis and indication treatment of the subclinical pelvic inflammation disease, and compared with clinic methods for diagnosis by operation, the biomarkers have obvious advantages.

Description

technical field [0001] The invention relates to the technical field of in vitro diagnosis, in particular to a variety of new subclinical pelvic inflammatory disease biomarkers and their application in detecting subclinical pelvic inflammatory disease. Background technique [0002] Pelvic inflammatory disease (Pelvic Inflammatory Disease, PID) is a common gynecological disease. Inflammation caused, including endometritis, salpingitis, etc. [1-4] . "2013 China Health Statistical Yearbook" data shows that the rate of women suffering from gynecological diseases in my country is 27.8%, of which 60%-80% are related to PID. The reason why PID has attracted widespread attention is that if PID is not treated promptly and effectively, it will cause more serious sequelae, including ectopic pregnancy, chronic pelvic pain, infertility caused by blocked fallopian tubes, etc. [5,6] , seriously affect the quality of life of women; if it causes tubal ovarian abscess rupture, diffuse perit...

Claims

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Application Information

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IPC IPC(8): G01N30/88
CPCG01N30/88G01N2030/8813
Inventor 邹威文晓柯周倩方超英陈小翠谢春红
Owner 湖南省妇幼保健院
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