35 results about "Phosphatidylethanol" patented technology

The present invention relates to a quercetin long-acting liposome powder injection and its preparation method. Said powder injection is formed from quercetin, polyethylene glycol-ethanolamine phosphoglycerides, lecithin, cholesterol and excipient. Said invention also provides the concrete steps of its preparation method.

The invention provides a polyethylene glycol-modified phospholipid derivative taking a 4-substituted anilino-quinazoline group as a targeting ligand and a preparation method thereof. The method comprises the following steps of: performing condensation with para-methylbenzene sulfonyl chloride, substitution with phthalimide potassium salt and hydrolysis with a hydrazine hydrate by taking polyethylene glycol (PEG) as a starting raw material to obtain diamine PEG; and reacting with targeting ligands, i.e., N-(3-chlorin-4-fluorin)-6-(3-chloropropyl)-7-methoxylquinazoline-4-amine and distearoylphosphatidylethanolamine (DSPE) to respectively obtain 4-anilino-quinazoline group-PEG-DSPE. A liposome preparation of the 4-anilino-quinazoline group-PEG-DSPE can be used for realizing target administration of tumor cells and reducing the toxic and side effects of a tumor medicament; and the pharmacodynamic structure of gefitinib can give play to dual medicament effects together with other liposome-coated antitumor medicaments, so that the tumor treatment effect is enhanced greatly.

The invention discloses an SPIO labeled pH sensitive drug-carrying liposome which is prepared from the following components in parts by mass: 1-10 parts of bulk drugs, 1-50 parts of phosphatidyl ethanolamine, 1-30 parts of cholesterol, 1-30 parts of linoleic acid, 0-10 parts of carboxymethyl chitosan, and 0-10 parts of superparamagnetic iron oxide nanoparticles. The invention further discloses a preparation method of the SPIO labeled pH sensitive drug-carrying liposome. The preparation method comprises the following steps: S1, placing phosphatidyl ethanolamine, cholesterol and linoleic acid ina flask, adding chloroform for dissolving, adding a water soluble drug solution for ultrasonic treatment to form a W / O emulsion; S2, evaporating to a gel state under the pressure reduction condition;adding a buffering solution, and continuously evaporating to form an aqueous suspension; S3, adding the superparamagnetic iron oxide nanoparticles and performing freeze thawing on a liposome suspension for three times; and centrifugally removing the superparamagnetic iron oxide nanoparticles and the water soluble drug not in the aqueous suspension; and S4, adding a carboxymethyl chitosan solutionfor hydration.

The invention discloses an application of hydroxycinnamic acid or phosphatidylethanolamine in early diagnosis of colorectal cancer. In a validation set of specific embodiments, the accuracy for distinguishing healthy subjects and colorectal cancer patients by taking hydroxycinnamic acid or phosphatidylethanolamine PE (18:2 (9Z,12z) / P-18:0) as a marker can reach 85.4% and 98.5%, the accuracy for distinguishing metabolic syndrome patients and colorectal cancer patients by taking hydroxycinnamic acid or phosphatidylethanolamine PE (18:2 (9Z,12z) / P-18:0) as the marker can reach 92.3% and 99.0%. Ascan be seen, hydroxycinnamic acid or phosphatidylethanolamine PE (18:2 (9Z,12z) / P-18:0) has a high diagnosis accuracy for colorectal cancer, can be prepared to a diagnosis kit for colorectal cancer and be used for early diagnosis of colorectal cancer in healthy people or metabolic syndrome patients.

The invention discloses a slow-release solid preparation of a doxycycline ambroxol medicine compound and a preparation method thereof. The preparation method comprises the following steps: preparing a vesica type phospholipid gel by adopting the following materials in parts by weight: 10 parts of doxycycline hydrochloride (count by doxycycline), 7 parts of ambroxol hydrochloride, 30-300 parts of distearoyl phosphatidylcholine ethanolamine and 10-100 parts of cholesterol succinate, and then adding frequently-used other medicinal excipients to the vesica type phospholipid gel of the doxycyclineambroxol medicine compound, thereby obtaining the slow-release solid preparation. According to the preparation method provided by the invention, the quality of preparation product is increased, the toxic side effect is reduced, the stability and dissolution rate as well as bioavailability of the medicine are greatly increased, the effect is stable and long-lasting, and the curative effect is obvious.

The objective is to provide an oily solid-form cosmetic, which exhibits excellent spreadability during use and when applied to the finger, reduced stickiness after application, and excellent storage stability and moisture retention. The oily solid-form cosmetic contains (a) 5-25 wt% of a phospholipid, wherein the phospholipid composition is 25-42% phosphatidylcholine and 25-42% phosphatidylethanolamine, (b) silicone oil having a kinematic viscosity of 1-100 mm2 / s at 25°C, and (c) an ester oil that is liquid at 25°C. The content ratio (b) / (c) of component (b) to component (c) is 0.006-0.4.

The invention discloses a meropenem liposome injection, which is characterized by mainly comprising the following components of: by weight, one part of meropenem, 2-8 parts of phosphatidylethanolamine, 1-5 parts of cholesterol, 0.2-1 part of polyether 188, 0.1-0.4 part of an antioxidant, and 5-10 parts of a supporting agent. The liposome injection prepared in the invention has good redissolving performance, good stability, high entrapment rate and little side-effect, can be used to raise the preparation product quality, minimize toxic and side effects and improve the bioavailability, and has remarkable curative effects.