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Officinal magnolia phenol lipid frozen dried powder preparation and its use in preparing drug for cancers

A technology of freeze-dried powder and preparation, applied in the directions of anti-tumor drugs, freeze-dried delivery, drug combination, etc., can solve the problems of not improving pharmacokinetics, unable to prolong the circulation time of honokiol, etc. Anti-tumor function, good sensitization and synergistic effect, effect of improving absorption and stability

Active Publication Date: 2007-01-17
CHENGDU JINRUI FOUND BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The research on honokiol mainly adopts honokiol and solubilizers such as fat emulsion or polyethylene glycol at present, as intralipid is prepared into emulsion, and animal is carried out intraperitoneal injection (Xianhe Bai, Francesca Cerimele, et al.Honokiol, a Small Molecular Weight Natural Product, Inhibits Angiogenesis in Vitro and Tumor Growth in Vivo. [J] The Juurnal of biological chemistry. 2003, 37(278): 35501-35507. Fei Chen, Tao Wang, Yi-Feng Wu, Ying Gu, Xiao-Li Xu, Shu Zheng, Xun HuHonokiol: A potent chemotherapy candidate for human colorectal carcinoma. [J] World J Gastroenterol 2004; 10(23): 3459-3463), although this method solves the water-soluble problem of honokiol , does not improve the pharmacokinetics of the pharmaceutical composition containing honokiol, nor can it prolong the circulation time of honokiol in the body to realize the targeted therapy of honokiol

Method used

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  • Officinal magnolia phenol lipid frozen dried powder preparation and its use in preparing drug for cancers
  • Officinal magnolia phenol lipid frozen dried powder preparation and its use in preparing drug for cancers
  • Officinal magnolia phenol lipid frozen dried powder preparation and its use in preparing drug for cancers

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0081] Weigh 20 mg of honokiol, 60 mg of lecithin, 8 mg of cholesterol, 12 mg of polyethylene glycol-phosphatidylethanolamine with a molecular mass of polyethylene glycol of 2000, 1 mg of sorbitol, and 0.1 mg of vitamin C;

[0082] The above-mentioned weighed lecithin, cholesterol, polyethylene glycol-phosphatidylethanolamine and honokiol are dissolved in an organic solvent of 100ml of chloroform and methyl alcohol prepared in proportion, wherein chloroform is 75ml , methanol is 25ml, stir in a closed bottle until it is completely dissolved, put the completely dissolved solution in a 250ml flask, connect the flask to a rotary evaporator, immerse the flask in a constant temperature water bath at 40°C, and vacuum the rotary evaporation to remove organic matter. Solvent, at this moment, form a uniform layer of phospholipid film on the wall of the flask, then put it into a vacuum drying oven, dry it at room temperature for 2 hours, add 100ml of sterilized water, and carry out ultra...

Embodiment 2

[0084] Weighing honokiol 35mg, lecithin 45mg, cholesterol 12mg, polyethylene glycol molecular weight 4000 polyethylene glycol-phosphatidylethanolamine 8mg, sorbitol 0.5mg, vitamin C 0.5mg;

[0085] Honokiol liposome freeze-dried powder was prepared according to the conditions of use and operation steps in Example 1, which was vacuumized or filled with an inert gas to seal, and stored at a temperature of 4°C-8°C for future use.

Embodiment 3

[0087] Weigh honokiol 50mg, lecithin 40mg, cholesterol 5mg, polyethylene glycol molecular weight 8000 polyethylene glycol-phosphatidylethanolamine 5mg, glucose 4mg, vitamin C 0.1mg;

[0088] Honokiol liposome freeze-dried powder was prepared according to the conditions of use and operation steps in Example 1, which was vacuumized or filled with an inert gas to seal, and stored at a temperature of 4°C-8°C for future use.

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Abstract

A freeze-dried powder of honokiol liposome for preparing the medicines to treat lung cancer and mammary cancer is proportionally prepared from honokiol, polyethanediol-phosphatidylethanolamine, lecithin and cholesterol. It has high synergistic and sensitizing action when it is applied in conjunction with chemicotherapeutic medicine.

Description

technical field [0001] The present invention relates to honokiol liposome freeze-dried powder preparation and application thereof, particularly relates to the new application in the preparation of the medicine for treating malignant tumors, also relates to the combination with radiotherapy and / or chemotherapeutic medicine in the preparation of the medicine for treating malignant tumors new application. technical background [0002] Tumor is a multi-mechanism complex disease that threatens human health, especially malignant tumor is the enemy that threatens human health. At present, the treatment of malignant tumors still adopts comprehensive methods such as early diagnosis, radiotherapy, and chemotherapy. But in the process of radiotherapy or chemotherapy to treat tumors, while killing tumor cells, it will also cause damage to some normal tissues and cells such as bone marrow, digestive tract, liver, and kidney. For example, the chemotherapy process can cause inflammation,...

Claims

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Application Information

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IPC IPC(8): A61K31/05A61K9/19A61P35/00A61K31/282A61K31/337A61K31/704
Inventor 魏于全陈俐娟范琳玉
Owner CHENGDU JINRUI FOUND BIOTECH CO LTD
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