46results about How to "High tumor inhibition rate" patented technology

The invention discloses a preparation method and application of metal organic framework drug carrier system based on drug cytosine arabinoside micromolecule prodrug. The preparation method disclosed by the invention comprises the steps: choosing molecules which can generate coordination reaction with metal ions to be covalently combined with cytosine arabinoside to synthesize novel multifunctionalmicromolecule prodrug; carrying the prodrug on the metal organic framework through a simple environment-friendly one-step entrapment method to form medicine carrying nanoparticles; centrifuging, washing and drying to obtain a cytosine arabinoside micromolecule prodrug carrying MOF intravenous injection preparation. Taking synthesized Ara-IR820@ZIF-8 as an example, a mouse in-vivo antitumor pharmacological result shows that HA/Ara-IR820@ZIF-8 nano water solution has a good antitumor effect and lower system toxicity. The intravenous injection preparation has the advantages of high medicine carrying amount, simple and economic preparation process, batch production, small toxicity, good safety and wide application prospect in achieving high medicine carrying amount of the cytosine arabinosidein the metal organic framework and applying intravenous injection dosage to treat solid tumors.

The invention discloses an extraction method of a land slug and an anti-lung cancer application of the land slug. The extraction method comprises the following steps: (1) carrying out vacuum freeze-drying on the land slug, adding purified water and then carrying out water bath agitation, adding a high-concentration ethanol solution, evenly agitating until the ethanol concentration is 60-70%, standing and then carrying out solid-liquid separation; (2) clarifying and intercepting the liquid obtained in the step (1) by adopting an inorganic ceramic membrane system, so as to obtain total clear liquid of the land slug; (3) concentrating the total clear liquid of the land slug obtained in the step (2) by a reverse osmosis membrane; and (4) concentrating and drying ultra-filtrate obtained in the step (3), so as to obtain water-soluble land slug powder. The molecular weight of the land slug powder obtained by the method is concentrated between 20,000 and 30,000, and has a significant antitumor effect; the tumor control rate is higher than that of cinobufagin and close to that of cyclophosphamide. The water-soluble land slug powder disclosed by the invention is used for treating a lung cancer, and is efficient and low-toxicity.

The invention relates to metal fullerols and its application in preparing inhibition tumor medicine. Its general formula is M@C2m(OH)x, which M can be Gd, La, etc, m=41 or 30, x is not less than 10 and less than 50; it also can be M@C2mOxHy. Compared with clinic common using cyclophosphamide, cisplatin, paclitaxel etc, the metal fullerols M@C2m(OH)x or M@C2mOxHy has the advantages of little use level, low toxicity, high tumor inhibition ratio.

The invention develops a developed a thermosensitive injectable hydrogel based on HA and a copolymer of polyethylene oxide (PEO) and polypropylene oxide (PPO), which has a gel formation temperature from 30° C. to 37° C. The thermosensitive injectable hydrogel of the invention provides a potential drug delivery system that can increase therapeutic efficacy of the drug.

The invention relates to a vincristine-reversion agent compound nano particle, a preparation thereof and applications, belonging to the medicine field. A first technical problem to be solved by the invention is: overcoming the phenomena of multidrug resistance MDR of various tumor cells to the vincristine, namely, the vincristine and the reversion agent are wrapped and carried in a PLGA in a compound way, for preparing the nano particles. With the purposes of obtaining the smaller-diameter nano particles and reducing the vestigital of the surface active agent, F68 and TPGS are adopted as the surface active agent; compared with PVA, the TPGS and the F68 can obviously increase the mortality of drug-resistant breast cancer cells (p is smaller than 0.05); and the tumor-inhibition rate of the TPGS is obviously higher than that of the F68.

The invention belongs to the field of biotechnology and especially relates to a method for activation of a prodrug by tumor targeting bacteria and a use thereof. The method utilizes tumor targeting bacteria as natural prodrug activation tools; and the tumor targeting bacteria can realize constitutive expression of an endogenic prodrug activation enzyme gene thereby specifically activate a prodrug in tumor tissue and thus the activated prodrug can produce tumor-resistant effects. The method can be used for tumor treatment.

The invention discloses tabletted sweets containing sulforaphen. The tabletted sweets comprise the following raw materials in parts by weight: 200-250 parts of sulforaphen crude extracts, 150-200 parts of maltodextrin, 30-50 parts of microcrystalline cellulose, 3-5 parts of magnesium stearate and 0.5-1 part of a sweetening agent. The invention further discloses a preparation method of the tabletted sweets and application of the tabletted sweets in the respect of restraining tumors. The prepared tabletted sweets disclosed by the invention can prevent the sulforaphen from being degraded, the problem of poor stability of the sulforaphen is effectively solved, and the quality guarantee period of the tabletted sweets under the storage conditions of being shadowy, cool and dry is 24 months. Because the tabletted sweets contain the sulforaphen, the tabletted sweets have a high tumor restraining rate. The tableted sweets can also effectively solve the problem that at present, sulforaphen products in the market are supplied rarely.

The invention belongs to the field of medicine preparations, which particularly relates to a long-circulation irinotecan lipidosome composition. The long-circulation irinotecan lipidosome composition is prepared from the following components in parts by weight: 1 part of irinotecan, 2 to 4 parts of hydrogenated soy phosphatidylcholine or distearoyl lecithin, 0.5 to 1.5 parts of cholesterol, 0.4 to 1.2 parts of phosphatidylethanolamine pegol and 0.0104 to 0.051 part of metal-chelator. The invention further discloses a preparation method of the long-circulation irinotecan lipidosome composition and an application of the long-circulation irinotecan lipidosome composition prepared into an irinotecan lipidosome composition injection. According to the irinotecan lipidosome composition and the preparation method thereof, the medicine loading ratio of the irinotecan is greatly improved and the encapsulation efficiency is greater than 99.5%, so that the toxic and side effect of the medicine which is not encapsulated can be obviously reduced; the content of relevant substances is lower than 0.5% and the limit of various toxic impurities is lower than 0.1%, so that the safety of the composition is obviously improved; and the composition is uniform in granularity distribution and good in stability.

The invention discloses a probiotic fermented traditional Chinese medicine compound composition for treating liver cancer and preparation and detection methods thereof. The preparation method includes: performing water extraction on traditional Chinese medicine compound medicinal materials; adding nutrient and inorganic salt different in proportion; sterilizing at high temperature, and performing compound intestinal tract probiotic fermentation; stabilizing to obtain the probiotic fermented traditional Chinese medicine compound composition. The traditional Chinese medicine compound medicinal materials include Radix bupleuri, Radix scutellariae, Radix ginseng rubra, Herba hyperici japonici, string stonecrop herb, roasted turtle shell, root of red-rooted salvia, selfheal, raw oyster, Rhizoma corydalis, Radix curcuma piece, polyporus umbellatus and Radix Glycyrrhizae Preparata.The invention further discloses an identification method and a detection method of the probiotic fermented traditional Chinese medicine compound composition. Experiments show that treatment effect of traditional Chinese medicine extract can be improved remarkably, tumor inhibition rate can be increased, and the probiotic fermented traditional Chinese medicine compound composition has remarkable effect on inhibiting liver tumor growth. Taste of the traditional Chinese medicine compound extract can be improved remarkably, irritation of the traditional Chinese medicine extract to intestines and stomach can be reduced, and appetite and physique of patients can be improved.

The invention provides rare earth-DNA photo-thermal hydrogel for injection. The hydrogel comprises DNA molecules with negative charges and a rare earth-based nano material with positive charges; and the rare earth-based nano material with the positive charges is UCNP-Au. The DNA molecules and the rare earth-based nano material form a hydrogel material with injectability, efficient photothermal therapy effect and biocompatibility under the action of physical winding, hydrogen bonds and electrostatic force. Experimental results show that the photo-thermal efficiency of the injectable rare earth-DNA photo-thermal hydrogel disclosed by the invention can reach 42.67%. In addition, the tumor inhibition rate is increased, so that the recurrence and metastasis probability of tumors is reduced. Toxic and side effects of medicines on normal tissues in the treatment process are reduced through a paratumoral injection means. Moreover, the degradation of the photo-thermal hydrogel in any time period can be realized by regulating and controlling the ratio of the DNA molecules to the rare earth-based nano material. The hydrogel is simple and rapid to operate and low in tumor recurrence and metastasis probability.

The present invention provides a pharmaceutical composition for treating tumor and a preparation method thereof, wherein the pharmaceutical composition is prepared from Chinese Angelica and venenum bufonis. The pharmaceutical composition can significantly improve the tumor inhibition rate, and has significantly-improved antitumor activity compared with Antike capsule made from Chinese Angelica and Toad skin. The pharmaceutical composition is suitable for patients with advanced cancer, can be used as an antitumor adjuvant drug, can improve clinical symptoms and improves the quality of life.

The invention discloses a preparation method and application of NK cell synergistic stimulation polymer micelle. According to the preparation method of the NK cell synergistic stimulation polymer micelle, IL-15 and IL-2 are simultaneously loaded by using PEG-PTMC polymer to prepare the NK cell synergistic stimulation polymeric micelle (PEG-PTMC-IL-2/IL-15). The prepared NK cell synergistic stimulation polymeric micelle has high tumor inhibition rate, and is capable of effectively promoting apoptosis of tumor cells.

The invention discloses preparation of a dendrobium officinale polysaccharide lozenge and an application of the dendrobium officinale polysaccharide lozenge in immunopotentiation. The total extractionprocess of the polysaccharide comprises the following steps: decocting and extracting dendrobium officinale coarse powder with 40 times of water for 2 hours, filtering, concentrating the filtrate to0.2 g of crude drug/ml, and precipitating with 5 times of ethanol by a water extraction and alcohol precipitation method to obtain the dendrobium officinale polysaccharide powder. The mannitol, aspartame, magnesium stearate, microcrystalline cellulose, menthol and povidone are added into the dendrobium polysaccharide powder to prepare lozenge. The lozenge can improve yin deficiency symptoms of yindeficiency model mice caused by thyroid hormone. Peripheral blood leukocyte WBC reduction of S180 tumor-bearing mice caused by 60Co radiotherapy is improved, and the number of bone marrow nucleated cells is increased. The effects of improving the activity of the body, resisting oxidative damage and enhancing immunity are shown. The dendrobium officinale polysaccharide lozenge prepared by the optimal dendrobium officinale polysaccharide extraction process screened by the invention has an obvious immunopotentiation effect, and can be used in the fields of immunopotentiation medicines, health-care products and foods.

The invention discloses an antitumor pharmaceutical composition and application thereof. The active ingredients of the antitumor pharmaceutical composition comprise polyethylene glycol modified camptothecin derivatives (especially polyethylene glycol modified irinotecan) and temozolomide. Animal experiments prove that the polyethylene glycol modified camptothecin derivatives (especially polyethylene glycol modified irinotecan) and temozolomide have an extremely strong treatment effect on tumors (such as neuroblastoma) by combined administration, and the tumor inhibition rate can reach 98% andis obviously superior to that of a single drug treatment group, so that the antitumor pharmaceutical composition provided by the invention has excellent application prospects in tumor treatment.

The invention provides a lenvatinib (Len) liposome, a pharmaceutical composition thereof, a preparation method thereof and a prescription process optimization method. The liposome contains lenvatinib, phospholipid, an amphiphilic derivative, cholesterol and a gradient establishing substance, wherein the weight ratio of cholesterol to phospholipid is 1:2-1:10, the weight ratio of lenvatinib to phospholipid is 1:10-1:40, the weight ratio of the amphiphilic derivative to the phospholipid is 1:2-1:10, the phospholipid is glycerophospholipid or sphingomyelin, the gradient adopts a pH gradient method or an amine gradient method, and the concentration of the gradient establishing substance solution is 100-300mM. The Len liposome can actively target a tumor site through an SA-Siglec1 pathway, has the advantages of high encapsulation efficiency, high stability, high active targeting, high tumor inhibition rate and the like, and has good clinical application potential and product development value.

The invention provides lactobacillus kefiranofaciens, a microbial agent and application of the lactobacillus kefiranofaciens, and belongs to the technical field of microbial agents. The lactobacillus kefiranofaciens ZW18 disclosed by the invention can regulate tumor immunity, stimulate CD8 cell infiltration and promote expression of interleukin-12 (IL-12) and interferon gamma (IFN-gamma), so that tumor growth is slowed down. Secondly, the lactobacillus kefiranofaciens ZW18 can be used for optimizing the intestinal flora structure and improving the micro-ecological environment of the intestinal tract, and the abundance of beneficial bacteria such as PrevoteraceaeNK3B31group, Parabacteroides and the like in the intestinal tract can be improved; the beneficial bacteria can be metabolized to generate substances such as short-chain fatty acid, and organism immunity is regulated through blood, so that tumor growth is slowed down. In addition, the lactobacillus kefiranofaciens ZW18 can enhance the anti-tumor effect of the immune checkpoint therapy and overcome the anti-tumor drug resistance of the immune checkpoint therapy.

The invention relates to MMP response type nanometer adriamycin-indocyanine green carrying hydrogel. A preparation method of the MMP response type nanometer adriamycin-indocyanine green carrying hydrogel comprises the following steps of: (1) preparing nanometer adriamycin granules and nanometer indocyanine green granules by an anti-solvent method, and performing freeze-drying and storage; and (2)accurately weighing a given amount of nanometer adriamycin freeze-dried powder and a given amount of nanometer indocyanine green freeze-dried powder, adding a TEA buffer solution, performing uniform mixing, accurately weighing a given quantity of acrylic ester-hyaluronic acid derivatives (HA-AC), adding the TEA buffer solution, performing uniform mixing, mixing two solutions in a certain proportion, adding an HS-MMP-SH cross-linking agent, performing placing in a thermotank of 37 DEG C, and performing cross-linking to obtain gel. According to the preparation method disclosed by the invention,MMP response type hydrogel is used as a carrier to wrap the nanometer adriamycin and nanometer indocyanine green, the MMP response type nanometer adriamycin-indocyanine green carrying hydrogel is injected into tumor positions in situ, and tumor cells can secrete a large amount of MMP, so that the hydrogel can be responded in the tumor position, degradation is accelerated, and controlled release and slow release of medicines can be realized; and besides, phototherapy and chemotherapy are united, so that the tumor restraining efficiency can be strengthened, and side effects of heart toxicity, skin phototoxicity and the like can be reduced.