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A pharmaceutical composition for treating tumors, its preparation method and application

The technology of a composition and medicine is applied in the pharmaceutical composition for treating tumor and its preparation, and the application field of medicine can solve the problems of limited number of tumors and curative effect, so as to improve the tumor inhibition rate, improve the extraction yield, and improve the anti-tumor effect. The effect of tumor activity

Active Publication Date: 2020-04-10
长春雷允上药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the number and curative effect of traditional Chinese medicines used clinically to treat tumors are very limited. Therefore, it is of great significance to further develop effective drugs for treating tumors from my country's rich resources of traditional Chinese medicine.

Method used

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  • A pharmaceutical composition for treating tumors, its preparation method and application
  • A pharmaceutical composition for treating tumors, its preparation method and application
  • A pharmaceutical composition for treating tumors, its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Preparation of Angelica Extract

[0028] Angelica medicinal material is cut and pulverized to obtain angelica powder. The angelica powder was reflux extracted once with an ethanol aqueous solution with a concentration of 3 times the mass of the angelica powder and a concentration of 90% (v / v), refluxed for 2.5 hours each time, and filtered to obtain an ethanol water extract of angelica and angelica dregs; Adding 6 times the mass of water based on the mass of Angelica sinensis to Angelica sinensis, decocting and extracting twice for 0.5 hours each time to obtain Angelica water extract.

[0029] Preparation of toad venom extract

[0030] Crush toad venom into toad venom powder, take toad venom powder, add 0.5% (g / ml) sodium chloride aqueous solution with a concentration of 0.5% (g / ml) in an amount 10 times the mass of toad venom powder, grind it into toad venom milk, then add 100 times the mass of toad venom milk The quality and concentration of 45% ethanol aqueous solu...

Embodiment 2

[0033] Preparation of Angelica Extract

[0034] Angelica medicinal material is cut and pulverized to obtain angelica powder. The Angelica sinensis powder obtained is refluxed and extracted 5 times with 45% ethanol aqueous solution according to the mass of Angelica sinensis powder, and refluxed for 0.5 hours each time, and filtered to obtain Angelica sinensis ethanol water extract and Angelica dregs; Add 1 times the mass of water based on the mass of Angelica dregs, decoct and extract 4 times, each time for 0.5 hours, to obtain Angelica water extract.

[0035] Preparation of toad venom extract

[0036] Crush toad venom into toad venom powder, take toad venom powder, add 45 times the mass of toad venom powder by mass, and a concentration of 4.5% (m / v) sodium chloride aqueous solution, grind into toad venom milk, then add 55 times the mass of ethanol aqueous solution with a concentration of 75% (v / v), extracted twice at 30° C. for 8 hours each time to obtain the extract of toad...

Embodiment 3

[0039] Comparison of extraction methods of toad venom

[0040] existing method

[0041] Take toad venom powder, add 80% ethanol aqueous solution of 10 times the mass based on the mass of toad venom powder, reflux extraction for 1.5 hours each time, extract 3 times, combine the extracts, concentrate in a water bath, calculate the yield of the extract, and the extraction results are shown in the following table 1.

[0042] Table 1

[0043] serial number Sampling amount of toad powder Extract weight yield 1 0.21g 0.071g 33.8％ 2 0.22g 0.073g 33.2％ 3 0.20g 0.069g 34.5％ 4 0.19g 0.065g 34.2％ 5 0.23g 0.078g 33.9％

[0044]Method of the present invention:

[0045] Take toad venom powder, add 0.9% (g / ml) sodium chloride aqueous solution with a mass concentration of 30 times the mass of toad venom powder, grind it into toad venom milk at room temperature, then heat it to 40°C and grind it for 30 minutes, then add 70 times the mass...

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Abstract

The present invention provides a pharmaceutical composition for treating tumor and a preparation method thereof, wherein the pharmaceutical composition is prepared from Chinese Angelica and venenum bufonis. The pharmaceutical composition can significantly improve the tumor inhibition rate, and has significantly-improved antitumor activity compared with Antike capsule made from Chinese Angelica and Toad skin. The pharmaceutical composition is suitable for patients with advanced cancer, can be used as an antitumor adjuvant drug, can improve clinical symptoms and improves the quality of life.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a pharmaceutical composition for treating tumors, a preparation method thereof, and an application of the pharmaceutical composition in preparing medicines for treating esophageal cancer, gastric cancer and liver cancer. Background technique [0002] Cancer is one of the major diseases that endanger human health at present. For critical, severe, advanced cancer patients, elderly patients, systemic metastases and secondary recurrence patients who cannot be treated with surgery, radiotherapy and chemotherapy, or who are insensitive or resistant to radiotherapy and chemotherapy For patients, traditional Chinese medicine can enhance the body's anti-cancer immunity, control the disease, relieve the disease, reduce and improve the symptoms and signs of tumor patients (such as pain, fatigue, weight loss, fever, anorexia, pleural effusion, gastrointestinal obstruction...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/232A61P35/00A61K35/65
CPCA61K35/65A61K36/232A61K2236/331A61K2236/333A61K2236/39A61K2300/00
Inventor 孙丽
Owner 长春雷允上药业有限公司
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