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Composition containing nitrate, gastric floatation agent, preparation method and application

A technology of nitrate and composition, which is applied in the field of medicine, can solve problems such as the inability to effectively maintain blood nitrate content, and achieve the effects of preventing cancer cell proliferation, regulating cardiovascular function, and preventing liver degenerative diseases and hepatic fatty degeneration

Active Publication Date: 2022-06-17
AIXI BEIJING INT CONSULTING CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, current nitrate preparations are not effective in maintaining blood nitrate levels after administration

Method used

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  • Composition containing nitrate, gastric floatation agent, preparation method and application
  • Composition containing nitrate, gastric floatation agent, preparation method and application
  • Composition containing nitrate, gastric floatation agent, preparation method and application

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preparation example Construction

[0045] The present invention also provides the preparation method of the gastric floatation agent described in the above scheme, comprising the following steps:

[0046] 1) mixing the composition described in the above scheme, the core material binder and the core material lubricant, and passing through a 20-mesh sieve to obtain core-spun particles;

[0047] 2) mixing cetyl alcohol, polyethylene glycol 3000 and ethylene-vinyl acetate copolymer 28 / 250 to obtain coated particles;

[0048] 3) Mix hydroxypropyl methyl brazing vitamin K4M, sodium bicarbonate, floating layer adhesive and floating layer lubricant, and cross 20 mesh sieves to obtain floating layer particles;

[0049] 4) using the coating particles in step 2) as the packaging material to coat the core particles in step 1); pressing the floating layer particles obtained in step 3) on the surface of the obtained core shell particles to form a floating layer, get gastric floaters;

[0050] There is no time sequence rest...

Embodiment 1

[0057] Composition 1: Sodium Nitrate 0.85g, Vitamin C 0.176g, Vitamin B 2 0.188g (substance ratio 10:1:0.5);

[0058] Composition 2: Sodium Nitrate 0.51g, Vitamin C 0.176g, Vitamin B 2 0.188g (the mass ratio of the substance: the mass ratio of the substance is 6:1:0.5);

[0059] Composition 3: Sodium Nitrate 0.51g, Vitamin C 0.528g, Vitamin B 2 0.564g (material ratio 1:1:0.5);

[0060] Composition 4: Sodium Nitrate 0.51g, Vitamin C 1.056g, Vitamin B 2 1.128g (material ratio 1:1:0.5);

[0061] Composition 5: Sodium Nitrate 0.85g, Vitamin C 3.52g, Vitamin B 2 3.76g (substance ratio 1:2:1);

[0062] Preparation method: Weigh corresponding amounts of sodium nitrate, vitamin C and vitamin B respectively according to the above ratios 2 , nitrate, vitamin C and vitamin B 2 Dissolve separately, filter and sterilize 0.22μm microporous membrane, mix them according to different proportions, distribute the mixed solution into sterile vials, seal, freeze at -20~-60℃ for 2~18h, and ...

Embodiment 2

[0064] Materials and reagents used:

[0065] Magnesium Stearate, Sodium Bicarbonate, Ethanol, Cetyl Alcohol, Hypromellose (K4M), Cross-linked Polyvinyl Pyrrolidone (PVPP), Polyethylene Glycol 3000 (PEG 3000), Ethylene Vinyl Acetate Copolymer 28 / 250 (EVA28 / 250), nitrates, vitamins, 40 mesh screen, 20 mesh screen, mortar, oven, rotary core wrapping machine.

[0066] Step 1. Preparation of tablet cores: tablet cores are made by conventional direct compression or wet granulation; the formula and proportion of tablet cores:

[0067] Ingredient dosage / 1000 tablets

[0068] In the examples of the present invention, compositions 1 to 5 (nitrate+vitamin C+vitamin B 2 ) 40g

[0069] Cross-linked polyvinylpyrrolidone 15g

[0070] Preparation method: after mixing 40g of nitrate+vitamin composition and 15g of cross-linked polyvinylpyrrolidone, use 5% cross-linked polyvinylpyrrolidone ethanol solution as a binder to make a soft material, pass through a 20-mesh sieve and granulate at 50 ...

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Abstract

The invention provides a composition containing nitrate, a gastric flotation agent, a preparation method and application thereof, and belongs to the technical field of medicine; the composition includes the following raw materials: nitrate, vitamin C and vitamin B 2 . The composition of the invention can significantly increase the content of nitrate in the body, maintain blood drug concentration, produce radiation damage protection, and improve bioavailability. The composition of the present invention can be used to regulate cardiovascular function, improve and / or treat gastrointestinal stress injury, prevent liver degeneration and hepatic steatosis, or reduce damage caused by whole body radiation without any adverse side effects.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a nitrate-containing composition, a gastric flotation agent, a preparation method and application thereof. Background technique [0002] Nitrates and nitrites are widely found in water, soil, air and plants. The main source of nitrate absorption by the human body is food, and green vegetables account for the main part. [0003] Nitrates exert physiological functions in various systemic activities, including blood pressure lowering, platelet aggregation inhibition, and vascular protection (Lundberg JO et al., Cardiovasc Res, 2011; Kapil V et al, Nitric Oxide, 2014). Nitrates prevent ischemic heart disease by increasing vasodilating epicardial blood flow, reducing vascular resistance, attenuating coronary steal, and reducing preload (Pragani MA et al., Rev Cardiovasc Med, 2017). Dietary nitrate can partially improve age-related hypertension and metabolic activity in mice by redu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/00A61K33/06A61K31/375A61K31/525A61K9/16A61K47/38A61K47/10A61K47/32A61K47/02A61P35/00A61P9/00A61P1/00A61P1/16A61P39/00
CPCA61K33/00A61K33/06A61K31/375A61K31/525A61K9/1641A61K9/1617A61K9/1635A61K9/1652A61K9/1611A61P35/00A61P9/00A61P1/00A61P1/16A61P39/00A61K2300/00
Inventor 王松灵王玉记
Owner AIXI BEIJING INT CONSULTING CO LTD
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