42results about How to "Uniform and stable particle size" patented technology

The sol-gel process of preparing nanometer gallium nitride crystal includes the first sol-gel process to prepare gallium oxide-amorphous carbon mixture through dissolving gallium nitrate in concentrated nitric acid, dropping concentrated ammonia water to regulate pH value, heating the solution, adding citric acid, stirring for 2 hr to obtain transparent gel, and drying the gel at high temperature in a muffle; and the subsequent preparation of nanometer gallium nitride crystal inside one tubular vacuum furnace through setting the gallium oxide-amorphous carbon mixture into a ceramic tube, exhausting air and filling with nitrogen, maintaining at 850-950 deg.C for 1 hr, and introducing argon to cool. The prepared nanometer gallium nitride crystal has hexagonal structure, average particle size of 10-11 nm and homogeneous particle size, and may be used in preparing high quality one-dimensional gallium nitride material or as composite gallium nitride quantum dot material directly.

The invention discloses a eucommia-ulmoides solid health beverage and a preparing method thereof. The eucommia-ulmoides solid health beverage is characterized by being prepared from, by weight, 20 parts to 30 parts of eucommia-ulmoides mixed extract powder, 6 parts to 7 parts of schisandra-chinensis ultra-fine powder, 10 parts to 15 parts of red-date ultra-fine powder, 20 parts to 30 parts of cane sugar, 0.8 part to 1 part of wolfberry ultra-fine powder, 3 parts to 5 parts of pumpkin ultra-fine powder, 0.5 part to 1.5 parts of black tea and 45 parts to 65 parts of soluble starch. The eucommia-ulmoides mixed extract powder is prepared from 10 parts to 15 parts of eucommia-ulmoides leaves and/or eucommia-ulmoides bark, 8 parts to 10 parts of buckwheat sprouts, 1 part to 1.5 parts of eleutherococcus senticosus, 0.5 part to 1 part of rhodiola rosea and 3 parts to 5 parts of honeysuckles; 5% ethanol solutions are added into the mixture in the proportion of 12:1, concentrating and spraying are carried out, and the eucommia-ulmoides mixed extract powder is prepared. According to the eucommia-ulmoides solid health beverage and the preparing method, the medicine and food homology theory of traditional Chinese medicine in China is adopted, eucommia ulmoides is used as main raw materials, medicine-and-food-homology or health-caring traditional dietetic invigoration raw materials such as red dates and schisandra chinensis are used for assisting, the beverage is safe and free of additives, a user can drink the beverage without worrying, and the dietary therapy healthy beverage which is easy to drink and has the multiple effects of resisting bacteria, diminishing inflammation, improving immunity, reducing blood fat and blood pressure, strengthening bones and muscles, resisting fatigue, being not prone to rotting and the like is prepared.

The invention relates to reducing response magnetic drug-loaded nanoparticles with synergetic anti-cancer interaction and a preparation method of the reducing response magnetic drug-loaded nanoparticles. The drug-loaded nanoparticles are prepared from a polymer prodrug and inorganic nanoparticles, which are connected through a disulfide bond; and the inorganic nanoparticles include surface-aminated superparamagnetism ferroferric oxide nanoparticles (SPION-NH2) and aminated selenium nanoparticles (NH2-R-SeNPs) employing an amino-containing high polymer as a template. The preparation method specifically comprises the following steps: (1) mixing an SPION-NH2 solution with an NH2-R-SeNPs dispersing liquid and adjusting the pH value to be 4.5-5.5; (2) dissolving the polymer prodrug connected through the disulfide bond by using ultrapure water and adjusting the pH value to be 5; and (3) dropwise adding the solution obtained in step (1) to the solution obtained in step (2), adjusting the pH value of a system to be 7.4, stirring the solution at room temperature for 10-14h to obtain the reducing response magnetic drug-loaded nanoparticles with synergetic anti-cancer interaction. The drug-loaded nanoparticles have the advantages of specific responsiveness in a targeted area, synergetic interaction and a low toxic or side effect.

The invention discloses a novel nano pesticide for preventing and treating monochamus alternatus and pine wood nematodes. The novel nano pesticide is a nano pesticide preparation prepared by taking nano Cu-BTC as a carrier to load pesticide abamectin; the nano Cu-BTC serving as the carrier is uniform and stable in particle size and good in dispersity, and agglomeration is avoided; the interior ofthe nano Cu-BTC is of a porous structure, so that the nano Cu-BTC has a relatively large specific surface area, high drug loading capacity and a quite good sustained and controlled release effect. Theprepared nano pesticide preparation can penetrate through cell wall barriers of plants due to the nano size, and the pesticide is transported into barks and is used for preventing and treating monochamus alternatus and pine wood nematodes.

The invention aims at providing furfuralcohol and urea composite modified water-soluble phenol-formaldehyde resin for a resin grinding tool and a preparation method of the furfuralcohol and urea composite modified water-soluble phenol-formaldehyde resin, wherein the furfuralcohol and urea composite modified water-soluble phenol-formaldehyde resin is proper in molar ratio, high in solid content, good in water solubility, low in free phenol content, stable in performance and reduced in performance degradation. The furfuralcohol and urea composite modified water-soluble phenol-formaldehyde resin comprises the following components in parts by mass: 100 parts of phenol, 10-35 parts of furfuralcohol, 120-180 parts of formaldehyde, 10-30 parts of urea, 1-10 parts of a moisturizing agent, 1.2-3.0 parts of an alkaline catalyst and 0.1-2 parts of a novel coupling agent. The preparation method of the phenol-formaldehyde resin comprises the following steps of (1) adding phenol, formaldehyde and part of furfuralcohol; (2) adding the alkaline catalyst; (3) heating; (4) adding part of the urea; (5) heating, adding the left furfuralcohol and urea, and stirring until the water solubility conforms to the standard; (6) cooling, reducing water, dehydrating, and adding the novel coupling agent; and (7) and carrying out reduced-pressure dehydration to obtain the furfuralcohol and urea composite modified water-soluble phenol-formaldehyde resin. The furfuralcohol and urea composite modified water-soluble phenol-formaldehyde resin is applied to the field of friction materials.

The invention discloses a nano composite high-hygroscopicity material and a preparation method therefor. According to the nano composite high-hygroscopicity material and the preparation method therefor, silica sol is dispersed in an acrylic neutralizing solution for modification, SiO2 nanoparticles are produced in situ during cross-linking copolymerization of acrylic acid and an acrylamide monomer, and then, reactive compounding of SiO2 nanoparticles and a polyacrylic polymer is achieved; the prepared nano composite high-hygroscopicity material is prepared from a low-crosslinking-degree resinmatrix with high water absorption multiplying power and high water absorption rate and a nano composite high-crosslinking-degree surface layer, the water absorption multiplying power is increased under pressure, and finally, the high-hygroscopicity composite material is prepared; the dispersity is good; and meanwhile, microchannels are formed between inorganic nanoparticles and a polymer, the volatilized overflow of internal water molecules is facilitated, the drying effect of the high-hygroscopicity material is better, the drying time is shortened obviously, the production efficiency is increased, the production cost is reduced, and thus, the nano composite high-hygroscopicity material is suitable for being produced on a large scale and has an extensive application prospect.

The invention discloses a rotor and a dispersion machine for dispersing materials. According to the rotor and the dispersion machine for dispersing the materials, the rotor is of a rotating body structure and comprises an outer wall, and the interior of the rotor is of a hollow structure; a support frame is arranged in the hollow structure and fixedly connected with the rotor; a connecting hole used for mounting an input shaft which drives the rotor to rotate at high speed is formed in the support frame, and a material flow hole is further formed in the support frame; and material dispersion holes distributed in an annular array are formed in the outer wall, and penetrate through the outer wall. The dispersing efficiency of the rotor and the dispersion machine is high, accordingly the energy consumption is reduced, energy is saved and environment is protected; and meanwhile, the rotor and the dispersion machine are simple in structure, and low in manufacturing and processing cost.

The invention relates to a gamma-tocotrienol-containing nano emulsion and a preparation method and use thereof. The nano emulsion is composed of the following components by mass percentage: gamma-tocotrienol 0.02%- 10%, injection oil 5%- 20%, emulsify 0.5%- 2%, isoosmotic adjusting agent 1.5%- 3.0%, antioxidant 0.005%- 0.5 % and that balance is water. By using emulsifier, gamma-tocotrienol and injectable oil are made into nanoparticles with small particle size, high content of active ingredients and stable, and no need to add excipients such as Tween, Span, preservatives and the like in the preparation, and the safety is higher. The gamma-tocotrienol nanoemulsion prepared by the invention expands the dosage form for clinical application.

The invention provides a spraying system based on urban rail traffic. The spraying system comprises a water bottle and high-pressure nitrogen bottle set, a water supply pipe net, a control valve set and novel fine water mist spraying heads, wherein the water bottle and high-pressure nitrogen bottle set is arranged at the bottom of a carriage, the water supply pipe net is arranged at the top and the periphery of the carriage, the control valve set is used for controlling the system to open and close, and the novel fine water mist spraying heads are installed at the top of the carriage; and thewater bottle and high-pressure nitrogen bottle set is connected to the water supply pipe net through the control valve set, and the tail ends of the water supply pipe net is connected to the fine water mist spraying heads. According to the spraying system, a bottle group type power source is adopted, the fire extinguishing structure is simple, and performance is high; and meanwhile, a novel designis carried out on the traditional fine water mist spraying heads, the novel fine water mist spraying heads adopt a dual filter screen structure and a plurality of water mist refining structures, morestable and uniform high-pressure fine water mist can be generated, and the system is more suitable for rail traffic vehicles.

The invention provides a lenvatinib (Len) liposome, a pharmaceutical composition thereof, a preparation method thereof and a prescription process optimization method. The liposome contains lenvatinib, phospholipid, an amphiphilic derivative, cholesterol and a gradient establishing substance, wherein the weight ratio of cholesterol to phospholipid is 1:2-1:10, the weight ratio of lenvatinib to phospholipid is 1:10-1:40, the weight ratio of the amphiphilic derivative to the phospholipid is 1:2-1:10, the phospholipid is glycerophospholipid or sphingomyelin, the gradient adopts a pH gradient method or an amine gradient method, and the concentration of the gradient establishing substance solution is 100-300mM. The Len liposome can actively target a tumor site through an SA-Siglec1 pathway, has the advantages of high encapsulation efficiency, high stability, high active targeting, high tumor inhibition rate and the like, and has good clinical application potential and product development value.

The invention provides a pharmaceutical composition for treating tumor and a preparation method and application thereof. The pharmaceutical composition comprises vorinostat and pharmaceutically acceptable adjuvant materials, wherein the pharmaceutically acceptable adjuvant materials comprise a filling agent, a binder, a disintegrating agent and a lubricating agent. The pharmaceutical composition and the preparation method thereof have the advantages that the pharmaceutically acceptable adjuvant materials are used to coordinate with the vorinostat so as to achieve even and stable particle granularity, and a fast dissolution feature is achieved to increase the antitumor effect of the vorinostat; during preparation, a fluidized bed top spray granulation method is used to allow the particle granularity to be even and stable, especially part of the filling agent is specifically used to prepare filling agent slurry which is mixed with a binder solution to serve as spraying liquid, the other part of the filling agent is mixed with other materials in a dry powder form to serve as fluidized bed materials, the particle granularity is well controlled through the spraying using the spraying liquid, particle properties are improved, stability is increased, preparation dissolution degree is increased, the preparation process is simple and controllable, and staff can be well protected.