Traditional Chinese medicine decocted extract used for eliminating female menopause symptoms, and preparation method for traditional Chinese medicine decocted extract

A technology for decoction and traditional Chinese medicine, which is applied to pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. and other problems, to achieve the effect of enhancing the body's protection of immunity, restoring kidney essence and temper, and reducing blood toxicity.

Inactive Publication Date: 2019-12-10
沈阳东星医药科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional Chinese medicine treats menopausal syndrome, although the side effects are small, but the treatment cycle is long, the curative effect is slow, and some methods are more complicated, so there are not many clinical applications
A series of traditional Chinese medicine preparations for the treatment of female syndrome currently on the market often focus on the composition of the formula, but ignore the rationality of the preparation dosage form and the optimization of each drug extraction method, resulting in the inability to give full play to the curative effect of each drug in the prescription, and even The loss of most active ingredients of drugs during the preparation process often brings the burden of high-dose and high-frequency administration to patients and certain economic losses to the society

Method used

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  • Traditional Chinese medicine decocted extract used for eliminating female menopause symptoms, and preparation method for traditional Chinese medicine decocted extract
  • Traditional Chinese medicine decocted extract used for eliminating female menopause symptoms, and preparation method for traditional Chinese medicine decocted extract
  • Traditional Chinese medicine decocted extract used for eliminating female menopause symptoms, and preparation method for traditional Chinese medicine decocted extract

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preparation example Construction

[0027] The invention provides the preparation method of the traditional Chinese medicine decoction for improving women's climacteric symptoms, comprising the following steps:

[0028]1) Mix 5 to 15 parts by weight of donkey skin, soaking agent, 3% sodium bicarbonate solution and water to obtain pre-soaked donkey skin, enzymatically hydrolyze the donkey skin with serine protease and serrapeptase successively to depilate the donkey skin, and dehair The final donkey skin and 1.3 times the weight of water are heated and solidified at 70°C to 90°C to obtain donkey-hide gelatin solidification solution;

[0029] 2) Mix 0.5-8.5 parts by weight of pearl powder with an average particle size of 80nm and an acetic acid solution with a volume concentration of 1%-45%, keep it at 80-160°C for 6-60h, adjust the resulting mixture to neutrality, and filter , to obtain pearl hydrolyzate;

[0030] 3) Pulverize 2.5-42.5 parts by weight of ginseng to obtain a powder of 80-120 mesh, wrap the powder...

Embodiment 1

[0048] 1) Stability experiment during ginseng preparation

[0049]Take 40g of ginseng and add 40ml of water, mix well, shake and extract with ether until the ether layer is colorless, then shake and extract with n-butanol saturated with water for 3 times, combine n-butanol extract with 20μl each time, wash with 50ml of ammonia test solution, Then wash with water for 3 times, evaporate to dryness with 20ml of n-butanol each time, add 0.5ml of methanol to dissolve the residue, and use it as the normal solution of the test sample. Take another ginsenoside Rg1 reference substance, add methanol to make a solution containing 1mg per 1ml, as the reference substance solution. According to the thin-layer chromatography (Appendix VIB, Chinese Pharmacopoeia 2015 Edition), 5 μl of each of the above two solutions was drawn, respectively spotted on the same silica gel G thin-layer plate, and mixed with chloroform-methanol-water (13:7:2 ), the lower layer solution placed below 10°C is the d...

Embodiment 2

[0059] 1) According to the pre-soaking procedure, take 5g of donkey skin as the medicinal material of the formula, add the above-mentioned donkey skin and water respectively according to the mass ratio of 1:1.5, control the water temperature at 18°C, add 0.5 times the mass of donkey skin soaking agent and 0.5 times the mass of donkey skin The mass concentration is 3% sodium bicarbonate solution, the pH value of the sodium bicarbonate solution is 8.5, rotate in the drum for 1 hour, stop for 2 hours, rotate for 1 hour, remove the meat from the drum, weigh, and end the presoaking procedure. The donkey skin depilation was carried out by the compound enzyme method, and the amino acid protease (alkaline protease) and serrapeptase (neutral protease) were added in a volume ratio of 5:5 in sequence, and the concentration of the enzyme solution was 1600U·mL -1 , the addition amount is 300U / pill, the enzymatic hydrolysis temperature is 30°C, the enzymatic hydrolysis time of serine proteas...

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Abstract

The invention provides a traditional Chinese medicine decocted extract used for eliminating female menopause symptoms, and a preparation method for the traditional Chinese medicine decocted extract, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine decocted extract comprises the following raw materials: colla corii asini, rehmanniae radix, fructus lycii, paeoniae alba radix, radix morindae officinalis, margarita, ginseng radix, radix asparagi, salt-processed fructus ligustri lucidi, rhizoma dioscoreae stir-baked with brans, rhizoma alismatis,fructus amomi, radix rehmanniae praeparata, radix polygoni multiflori praeparata, radix angelicae sinensis, herba cistanches and radix aucklandiae. An extraction method is optimized to guarantee thatthe extraction quantity of each effective ingredient is increased, and meanwhile, pollution links and manpower costs during medicine preparation can be reduced. The traditional Chinese medicine decocted extract is used for lightening dizziness and insomnia symptoms associated with female menopause, treating clinical female functional uterine bleeding and poor endometrial development phenomena, taking part in the auxiliary treatment of a glucose and lipid metabolism syndrome and a polycystic ovarian syndrome, and eliminating symptoms of female anemia and menstrual disorder, and also has good anti-ageing and anti-thrombus functions. The traditional Chinese medicine decocted extract can effectively make up the defects of an existing medicine, and achieves functions of treating diseases and improving female body functions.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine decoction for improving women's menopausal symptoms and a preparation method thereof. Background technique [0002] With the increasingly tense pace of modern life in society and increasingly fierce social competition, especially for most modern women, they often rush between family and career, and have no time to pay attention to their own health, causing many women in the menopause stage to feel mentally tired and dizzy during the day. , and insomnia at night. In the medical records of clinical treatment, women with uterine bleeding, poor endometrial growth, glucose and lipid metabolism syndrome, polycystic ovary syndrome, etc. are also common cases, and more and more women have early menopause. These symptoms are all comprehensive symptoms, and the ideal clinical treatment plan adopts the principle of "complement...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9064A61K9/06A61P15/12A61K35/36A61K35/618
CPCA61K9/0014A61K9/06A61K35/36A61K35/618A61K36/232A61K36/258A61K36/285A61K36/638A61K36/64A61K36/65A61K36/704A61K36/71A61K36/746A61K36/804A61K36/815A61K36/884A61K36/8945A61K36/8965A61K36/9064A61K47/46A61K2236/331A61K2236/333A61K2236/51A61P15/12A61K2300/00
Inventor 黄浩于叶玲唐星张兴东
Owner 沈阳东星医药科技有限公司
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