The invention discloses deer antler baijiu and making method thereof. The deer antler baijiu comprises raw materials as follows: deer antlers, deer's sinew, penis cervi, deer's tail, ginseng, twotoothed achyranthes roots, prepared rehmannia roots, desertliving cistanche, seeds of Chinese dodder, prepared common monkshood daughter roots, milkvetch roots, Chinese magnoliavine fruits, poria cocos, Chinese yam, Chinese angelica, dragon bone, thinleaf milkwort roots, red yeast rice, cane sugar, honey, ootheca mantidis and baijiu. The deer antler baijiu adopts a reasonable formula, is high in nutritive value, has the curative effects of nourishing yin and the kidney, strengthening tendons and bones, tonifying qi, nourishing body, resisting aging and the like, is good in healthcare effect and tastes good; the method adopts a simple process and is easy to implement, the preparation process is simple, by means of a double-soaking procedure, the extracting efficiency is greatly improved, so that nutritional ingredients of medicinal materials can be dissolved in baijiu better and more rapidly in an extracting process, the nutrition is richer, and the deer antler baijiu can have a good effect of maintaining and regulating physiological functions of a human body, has better healthcare effects and functions of improving gastrointestinal functions, resisting fatigue, nourishing yin and tonifying yang, enhancing blood circulation, dredging blood vessels, resisting aging, improving human body immunity and the like.