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Method for simultaneously loading zif-8 nanospheres with AuNPs and Fe3O4NPs

A technology of nanospheres and reduction method, which is applied in the direction of pharmaceutical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc. It can solve the problems of simultaneous loading of zif-8 nanospheres that have not been disclosed, and achieve high yield High, high loading capacity, uniform and stable particle size

Active Publication Date: 2020-01-14
BEIJING FORESTRY UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Here, we report a zif-8 nanosphere loaded with Au NPs and Fe 3 o 4 NPs method, there is no disclosure about how to simultaneously load Au NPs and Fe via zif-8 nanospheres 3 o 4 Related research on the method of NPs

Method used

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  • Method for simultaneously loading zif-8 nanospheres with AuNPs and Fe3O4NPs
  • Method for simultaneously loading zif-8 nanospheres with AuNPs and Fe3O4NPs
  • Method for simultaneously loading zif-8 nanospheres with AuNPs and Fe3O4NPs

Examples

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Embodiment 1

[0032] (1) Synthesize 13nm Au NPs by the sodium citrate reduction method described in the literature. Simply put 0.01%, 300mL chloroauric acid in a 500mL round bottom flask with a reflux condenser, stir vigorously and add 1% , 9mL trisodium citrate aqueous solution, react for 20min, until the solution turns red, quickly cool the obtained Au NPs solution with ice water, and set aside;

[0033] (2) Take the Au NPs in (1), add 50mL polyethylene glycol mPEG-SH, react for 2h, collect the precipitate by centrifugation at 16000rpm, wash with deionized water for 3 times, and disperse in methanol to obtain polyethylene glycol-stabilized Au NPs;

[0034] (3) Configure 100mL oleic acid-ethanol solution, the volume ratio of oleic acid to ethanol is 3:47, and take another 5mmol Fe(acac) 3 Add oleic acid-ethanol solution, mix and stir for 10 minutes, transfer to a 200mL steel-lined high-pressure reactor, and react at 180 degrees Celsius for 12 hours. times of washing to obtain oleic acid-...

Embodiment 2

[0038] (1) Synthesize 13nm Au NPs by the sodium citrate reduction method described in the literature. Simply put 0.01%, 300mL chloroauric acid in a 500mL round bottom flask with a reflux condenser, stir vigorously and add 1% , 9mL trisodium citrate aqueous solution, react for 20min, until the solution turns red, quickly cool the obtained Au NPs solution with ice water, and set aside;

[0039] (2) Take the Au NPs in (1), add 50mL polyethylene glycol mPEG-SH, react for 2h, collect the precipitate by centrifugation at 16000rpm, wash with deionized water for 3 times, and disperse in methanol to obtain polyethylene glycol-stabilized Au NPs;

[0040] (3) Configure 100mL oleic acid-ethanol solution, the volume ratio of oleic acid to ethanol is 3:47, and take another 1mmol Fe(acac) 3 Add oleic acid-ethanol solution, mix and stir for 10 minutes, transfer to a 200mL steel-lined high-pressure reactor, and react at 180 degrees Celsius for 12 hours. times of washing to obtain oleic acid-...

Embodiment 3

[0044] (1) Synthesize 13nm Au NPs by the sodium citrate reduction method described in the literature. Simply put 0.01%, 300mL chloroauric acid in a 500mL round bottom flask with a reflux condenser, stir vigorously and add 1% , 9mL trisodium citrate aqueous solution, react for 20min, until the solution turns red, quickly cool the obtained Au NPs solution with ice water, and set aside;

[0045] (2) Take the Au NPs in (1), add 50mL polyethylene glycol mPEG-SH, react for 2h, collect the precipitate by centrifugation at 16000rpm, wash with deionized water for 3 times, and disperse in methanol to obtain polyethylene glycol-stabilized Au NPs;

[0046] (3) Configure 100mL oleic acid-ethanol solution, the volume ratio of oleic acid to ethanol is 3:47, and take another 3mmol Fe(acac) 3 Add oleic acid-ethanol solution, mix and stir for 10 minutes, transfer to a 200mL steel-lined high-pressure reactor, and react at 180 degrees Celsius for 12 hours. times of washing to obtain oleic acid-...

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Abstract

The invention discloses a method for simultaneously loading zif-8 nanospheres with AuNPs and Fe3O4NPs. The method comprises the following steps: (1) preparing 13nm gold nanoparticles by a sodium citrate reduction method, and performing stabilization with polyethylene glycol mPEG-SH; (2) preparing Fe3O4 NPs with stable 12nm oleic acid by a reaction of iron (III) acetylacetone (Fe(acac)3) and oleicacid-ethanol, and performing stabilization with polyethylene glycol mPEG-COOH; and (3) adding substances obtained in the (1) and (2) into zinc nitrate, performing uniform stirring, adding dimethylimidazole into the mixture, performing a reaction to prepare the nanospheres of zif-8 simultaneously loaded with Au NPs and Fe3O4 NPs. The zif-8 nanospheres prepared by the method have photo-thermal performance and magnetic resonance imaging effect, can be applied to multiple uses including biological probes, magnetic targeting and the like, and are especially applicable to magnetic targeting administration and intracellular photothermal therapy of cancers. The technology for embedding two kinds of nanoparticles in zif-8 can be used for easily controlling the quantity of loaded Au NPs and Fe3O4 NPs, has high yield, and can realize large-scale preparation.

Description

technical field [0001] The invention relates to the field of new materials, in particular to a zif-8 nanosphere loaded with Au NPs and Fe 3 o 4 The method of NPs. Background technique [0002] Metal-organic frameworks (MOFs) are widely used in gas storage, catalysis, photothermal, nanofiltration membranes, and drug delivery due to their large internal surface area, uniformly tunable nanocavity, and stable morphology. In recent years, the preparation of nanometer-sized MOF (nanoMOF) has provided a broader application space for its application, especially in the field of drug delivery. The study found that small-sized rigid nanoparticles can be adsorbed on the surface of nanoMOFs or embedded in the cavities of nanoMOFs, resulting in hybrid crystals with novel chemical and physical properties, endowing them with photothermal properties or bioimaging applications, such as superparamagnetism γ-Fe 2 o 3 @MOF for targeted drug delivery and imaging, magnetic Fe 3 o 4 @IRMOF-3...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/52A61K47/69A61K41/00A61K49/08A61P35/00
CPCA61K47/52A61K47/6921A61K41/0052A61K49/08A61P35/00
Inventor 雷建都刘彦雪杨子萱李玉成孔天骄宗宇恒罗敏
Owner BEIJING FORESTRY UNIVERSITY
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