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A zif-8 nanosphere loaded with au NPs and Fe simultaneously 3 O 4 Methods for NPs

A technology of nanospheres and reduction method, which is applied in the direction of pharmaceutical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc. It can solve the problems of simultaneous loading of zif-8 nanospheres that have not been disclosed, and achieve high yield High, uniform and stable particle size, broad application prospects

Active Publication Date: 2022-07-01
BEIJING FORESTRY UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Here, we report a zif-8 nanosphere loaded with Au NPs and Fe 3 o 4 NPs method, there is no disclosure about how to simultaneously load Au NPs and Fe via zif-8 nanospheres 3 o 4 Related research on the method of NPs

Method used

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  • A zif-8 nanosphere loaded with au NPs and Fe simultaneously <sub>3</sub> O <sub>4</sub> Methods for NPs
  • A zif-8 nanosphere loaded with au NPs and Fe simultaneously <sub>3</sub> O <sub>4</sub> Methods for NPs
  • A zif-8 nanosphere loaded with au NPs and Fe simultaneously <sub>3</sub> O <sub>4</sub> Methods for NPs

Examples

Experimental program
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Embodiment 1

[0032] (1) Synthesize 13nmAu NPs by the sodium citrate reduction method, a classic method described in the literature. Simply, put 0.01%, 300 mL of chloroauric acid in a 500 mL round-bottomed flask with a reflux condenser, and start stirring to add 1% after vigorous boiling. , 9 mL of trisodium citrate aqueous solution, reacted for 20 min, until the solution turned red, the obtained Au NPs solution was rapidly cooled with ice water, for subsequent use;

[0033] (2) Take the Au NPs in (1), add 50 mL polyethylene glycol mPEG-SH, react for 2 h, collect the precipitate by centrifugation at 16000 rpm, disperse and wash it with deionized water for 3 times, and disperse it in methanol to obtain polyethylene glycol-stabilized Au NPs;

[0034] (3) configure 100mL oleic acid-ethanol solution, the volume ratio of oleic acid and ethanol is 3:47, and take another 5mmol Fe(acac) 3 Add oleic acid-ethanol solution, mix and stir for 10min, transfer to a 200mL steel-lined high-pressure reactor...

Embodiment 2

[0038] (1) Synthesize 13nmAu NPs by the sodium citrate reduction method, a classic method described in the literature, simply, put 0.01%, 300mL chloroauric acid in a 500mL round-bottomed flask with a reflux condenser, and start stirring to add 1% after vigorous boiling. , 9 mL of trisodium citrate aqueous solution, reacted for 20 min, until the solution turned red, the obtained Au NPs solution was rapidly cooled with ice water, for subsequent use;

[0039] (2) Take the Au NPs in (1), add 50 mL polyethylene glycol mPEG-SH, react for 2 h, collect the precipitate by centrifugation at 16000 rpm, disperse and wash it with deionized water 3 times, and disperse it in methanol to obtain polyethylene glycol-stabilized Au NPs;

[0040] (3) configure 100mL oleic acid-ethanol solution, the volume ratio of oleic acid and ethanol is 3:47, and take another 1mmol Fe(acac) 3 Add oleic acid-ethanol solution, mix and stir for 10min, transfer to a 200mL steel-lined high-pressure reaction kettle,...

Embodiment 3

[0044] (1) Synthesize 13nmAu NPs by the sodium citrate reduction method, a classic method described in the literature, simply, put 0.01%, 300mL chloroauric acid in a 500mL round-bottomed flask with a reflux condenser, and start stirring to add 1% after vigorous boiling. , 9 mL of trisodium citrate aqueous solution, reacted for 20 min, until the solution turned red, the obtained Au NPs solution was rapidly cooled with ice water, for subsequent use;

[0045] (2) Take the Au NPs in (1), add 50 mL polyethylene glycol mPEG-SH, react for 2 h, collect the precipitate by centrifugation at 16000 rpm, disperse and wash it with deionized water 3 times, and disperse it in methanol to obtain polyethylene glycol-stabilized Au NPs;

[0046] (3) configure 100mL oleic acid-ethanol solution, the volume ratio of oleic acid and ethanol is 3:47, and take another 3mmol Fe(acac) 3 Add oleic acid-ethanol solution, mix and stir for 10min, transfer to a 200mL steel-lined high-pressure reaction kettle,...

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Abstract

The invention discloses a zif-8 nano-sphere loaded with Au NPs and Fe at the same time 3 O 4 method for NPs. The specific steps are as follows: (1) 13nm gold nanoparticles were prepared by sodium citrate reduction method and stabilized with polyethylene glycol mPEG-SH; (2) iron (III) acetylacetone (Fe(acac) 3 ) react with oleic acid-ethanol to prepare 12 nm oleic acid-stabilized Fe 3 O 4 NPs, stabilized with polyethylene glycol mPEG-COOH; (3) adding (1) and (2) into zinc nitrate at the same time, stirring evenly, then adding dimethylimidazole, and reacting to prepare zif-8 while loading Au NPs and Fe 3 O 4 Nanospheres of NPs. The zif-8 nanospheres prepared by the invention have photothermal properties and magnetic resonance imaging effects, and can be used for various purposes such as biological probes, magnetic targeting, etc., and are especially suitable for magnetic targeting drug delivery and intracellular photothermal of cancer. treat. The technology obtained by this method to embed two nanoparticles in zif-8 is easy to control the loading of Au NPs and Fe 3 O 4 The amount and yield of NPs are high, and large-scale preparation can be realized.

Description

technical field [0001] The invention relates to the field of novel materials, in particular to a zif-8 nanosphere loaded with Au NPs and Fe at the same time 3 O 4 method for NPs. Background technique [0002] Metal-organic frameworks (MOFs) are widely used in gas storage, catalysis, photothermal, nanofiltration membranes, and drug delivery due to their large internal surface area, uniformly tunable nanocavities, and stable morphologies. In recent years, the preparation of nano-sized MOFs (nanoMOFs) has provided a broader application space for their applications, especially in the field of drug delivery. The study found that small-sized rigid nanoparticles can be adsorbed on the surface of nanoMOFs or embedded in the cavities of nanoMOFs, resulting in hybrid crystals with novel chemical and physical properties, giving them photothermal properties or bioimaging applications such as superparamagnetism γ-Fe 2 O 3 @MOF for targeted drug delivery and imaging, magnetic Fe 3 O...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/52A61K47/69A61K41/00A61K49/08A61P35/00
CPCA61K47/52A61K47/6921A61K41/0052A61K49/08A61P35/00
Inventor 雷建都刘彦雪杨子萱李玉成孔天骄宗宇恒罗敏
Owner BEIJING FORESTRY UNIVERSITY
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