Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Photo-thermal conversion nano composite material without toxic and side effects as well as preparation method and application thereof

A nano-composite material, non-toxic and side-effect technology, applied in the field of biomedicine, can solve problems such as toxic and side effects, insignificant photothermal efficacy, uneven polymerization, etc., and achieve the effects of low toxic and side effects, high biocompatibility, and reduced damage.

Pending Publication Date: 2022-08-02
JINLIN MEDICAL COLLEGE
View PDF9 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to solve the problems of inhomogeneous polymerization, insignificant photothermal curative effect, and certain toxic and side effects caused by the direct polymerization of dopamine on the fiber surface in the existing preparation method, the present invention provides a photothermal conversion nanocomposite material with no toxic and side effects and its Preparation method and application

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Photo-thermal conversion nano composite material without toxic and side effects as well as preparation method and application thereof
  • Photo-thermal conversion nano composite material without toxic and side effects as well as preparation method and application thereof
  • Photo-thermal conversion nano composite material without toxic and side effects as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0028] The preparation method of a photothermal conversion nanocomposite material without toxic and side effects of the present invention mainly comprises the following steps:

[0029] (1) After taking dopamine hydrochloride and adding ethanol and an aqueous solution to react, adding absolute ethanol to carry out ultrasonic dispersion, and obtaining polydopamine (PDA) nanoparticles after centrifugation.

[0030] (2) L-polylactic acid (PLLA, with an average molecular weight of 60,000 to 120,000) and polycaprolactone (PCL, with an average molecular weight of 30,000 to 80,000) two solids in a mass ratio of 1:3-4:1 Dissolve in dichloromethane solution, and after standing for a period of time, perform constant temperature magnetic stirring, and ultrasonically remove bubbles to form a uniform and transparent PLLA / PCL mixed sol. Add a small amount of anhydrous ethanol and mix evenly to obtain a PLLA / PCL mixed sol.

[0031] (3) After dissolving the anticancer drug into the PLLA / PCL bl...

Embodiment 1

[0037] Example 1 Preparation of photothermal conversion nanocomposites

[0038] (1) Take 0.5g of dopamine hydrochloride, add 40ml of ethanol and 90ml of aqueous solution, react at 37°C for 24h, add absolute ethanol for ultrasonic dispersion, and obtain polydopamine (PDA) nanoparticles with a diameter of about 70nm after centrifugation at 12,000 rpm ; After the polydopamine (PDA) nanoparticles were placed for one year, the zeta potential value of polydopamine was determined, and the value of the zeta potential remained basically unchanged, and its absolute value was about 50mV.

[0039] (2) Dissolve two solids of L-polylactic acid (PLLA) and polycaprolactone (PCL) in a dichloromethane solution with a mass ratio of 1:3, and after standing for a period of time, perform constant temperature magnetic stirring, and ultrasonically The air bubbles were removed to form a uniform and transparent PLLA / PCL mixed sol, and a small amount of absolute ethanol was added to mix uniformly to obt...

Embodiment 2

[0044] Example 2 Preparation of photothermal conversion nanocomposites

[0045] (1) Take 0.5g of dopamine hydrochloride, add 40ml of ethanol and 90ml of aqueous solution, react at 37°C for 24h, add absolute ethanol for ultrasonic dispersion, and obtain polydopamine (PDA) nanoparticles with a diameter of about 70nm after centrifugation at 12,000 rpm ; After the polydopamine (PDA) nanoparticles were placed for one year, the zeta potential value of polydopamine was determined, and the value of the zeta potential remained basically unchanged, and its absolute value was about 50mV.

[0046] (2) Dissolve two solids of L-polylactic acid (PLLA) and polycaprolactone (PCL) in a dichloromethane solution with a mass ratio of 1:1, and after standing for a period of time, perform constant temperature magnetic stirring, and ultrasonically The air bubbles were removed to form a uniform and transparent PLLA / PCL mixed sol, and a small amount of absolute ethanol was added to mix uniformly to obt...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
diameteraaaaaaaaaa
Login to View More

Abstract

The invention discloses a photo-thermal conversion nano composite material without toxic and side effects as well as a preparation method and application thereof, and relates to the field of biological medicines. The photo-thermal conversion nano composite material comprises the following components: 3-13% (w / v) of polydopamine nano particles, 2-5% (w / w) of an anti-cancer drug, L-polylactic acid and polycaprolactone, the mass ratio of the poly-L-lactic acid to the polycaprolactone is (1: 3)-(4: 1). The preparation method comprises the following steps: mixing poly-L-lactic acid and polycaprolactone to prepare a degradable polymer colloid, embedding three-dimensional photo-thermal nanoparticles polydopamine and an anti-cancer drug into the degradable polymer colloid, preparing a nanofiber membrane by adopting a high-voltage electrostatic spinning method, and treating to remove a toxic organic solvent to obtain the photo-thermal conversion nano composite material. The photo-thermal conversion nano composite material is free of toxic and side effects, remarkable in photo-thermal curative effect, good in biocompatibility, uniform in nano particle distribution, good in toughness, capable of generating a remarkable heat effect on tumor tissues and capable of effectively killing cancer cells.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a photothermal conversion nano-composite material without toxic and side effects and a preparation method and application thereof. Background technique [0002] Tumor is a complex disease with a high mortality rate worldwide. Treatment methods such as surgery, radiotherapy, chemotherapy, and interventional therapy are the main treatment measures for patients with solid tumors in the early stage, but tumor recurrence is still inevitable. There are several reasons for: (1) ineffective for extremely small residual or metastatic tumors, (2) for positive postoperative margins, (3) for increased incidence of wound complications and poor healing, (4) for The normal physiological functions of the human body are seriously damaged. Compared with radiotherapy and chemotherapy drugs, photothermal therapy does little damage to normal cells and is more likely to kill tumor cells. It is a ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K41/00A61K45/06A61K47/34A61P35/00D01D5/00
CPCA61K9/70A61K47/34A61K45/06A61K41/0052A61P35/00D01D5/003D01D5/0092
Inventor 李文亮隋春红王程刘甲雪肖箫王宝李向阳
Owner JINLIN MEDICAL COLLEGE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com