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Ultrasonic contrast agent

A technology of ultrasound contrast agent and shell material, which is applied in the direction of echo/ultrasound imaging agent, etc., and can solve the problems of stability time, cycle half-life period, and gas utilization rate not reaching the ideal effect.

Inactive Publication Date: 2016-01-13
张超
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the fact that the gas utilization rate of traditional contrast agents has not reached the ideal effect, the stability time and circulation half-life period

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] An ultrasound contrast agent is composed of shell material, gas and 6% dextran injection, wherein the weight percentage of the shell material consists of dipalmitoylphosphatidylcholine 10%, phosphatidylethanolamine 5%, polyvinylpyrrolidone 10%, Polyethylene glycol monostearate 10%, Span 8015%, sodium alginate 15%, sucrose ester 5%, water for injection 30%; gas is perfluorobutane and sulfur hexafluoride, the volume of the two The ratio is 1:3;

[0016] The preparation method comprises the following steps under aseptic conditions:

[0017] (1) Place dipalmitoylphosphatidylcholine and phosphatidylethanolamine in part of the water for injection, heat at 45°C and stir evenly, and set aside;

[0018] (2) Place polyvinylpyrrolidone and polyethylene glycol monostearate in the remaining water for injection, heat at 50°C and stir evenly, and set aside;

[0019] (3) Put Span 80, sodium alginate, and sucrose ester in 6% dextran injection, stir evenly, and set aside;

[0020] (4)...

Embodiment 2

[0049] Embodiment 2 effect test

[0050] The ultrasonic contrast agents of Example 1 and Comparative Examples 1-4 were tested, and a nude mouse liver cancer model was first established: culture SMMC7721 liver cancer cells in vitro, take cells with good morphology in logarithmic growth phase, discard the culture medium in the bottle, wash with PBS Digest with 0.25% trypsin, stop digestion with RPM11640 culture medium containing 10% calf serum, collect cells and centrifuge (1000rpm, 5min). Take out the nude mice in the ultra-clean workbench, sterilize the skin of the right forelimb armpit of the nude mice with 70% ethanol, and extract about 0.2ml with a 1ml syringe (the concentration is adjusted with normal saline and the number of cells is 2×10 6 1) the cell suspension was injected subcutaneously into the right forelimb of nude mice, and the injection point was 1 cm away from the needle point to form a skin mound. After inoculation, a sterile cotton swab was lightly pressed on ...

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PUM

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Abstract

The invention relates to an ultrasonic contrast agent which comprises a shell material, gas and a 6% dextran injection solution. The shell material is prepared from, by weight, 10% of dipalmitoyl phosphatidylcholine, 5% of phosphatidyl ethanolamine, 10% of polyvinylpyrrolidone, 10% of polyethylene glycol monostearate, 15% of span 80, 15% of sodium alginate, 5% of sucrose ester and 30% of injection water. The gas is prepared from perfluoro-n-butane and sulfur hexafluoride at the volume ratio of 1:3. The ultrasonic contrast agent has the advantages of being long in stable time, good in using effect, long in circulation half-life period and simple in preparing method, and has very high clinical application value.

Description

technical field [0001] The invention belongs to the field of contrast agents, in particular to an ultrasonic contrast agent. Background technique [0002] Ultrasound image generation relies on the reception, analysis, and display of reflected and scattered ultrasound signals. As a kind of medical imaging, it provides important functional and anatomical information of internal organs, and is a wide range of non-invasive detection methods. Ultrasound Doppler technology to assess the direction and velocity of blood flow improves the diagnostic ability of ultrasound, but it cannot evaluate blood flow in tissue microvessels because the signal of microvascular blood flow is lower than that of tissue. [0003] Ultrasound contrast agents (Ultrasound contrast agents, UCAs) are a class of diagnostic reagents that can significantly enhance the signal of medical ultrasound detection, and can improve the imaging effect of some organs and parts that cannot be developed or poorly develope...

Claims

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Application Information

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IPC IPC(8): A61K49/22
Inventor 张超王善良刘素霞徐后莹
Owner 张超
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