Quercetin long-acting liposome powder for injection and its preparing method
A technology of liposome powder and quercetin, which is applied in the directions of liposome delivery, medical preparations without active ingredients, and medical preparations containing active ingredients, etc. , purification and other issues, to achieve the effect of improving absorption and stability, prolonging blood circulation time, and improving pharmacokinetics
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Embodiment 1
[0073] Dissolve 60mg of lecithin, 6mg of cholesterol, 12mg of polyethylene glycol-phosphatidylethanolamine, the molecular weight of polyethylene glycol in polyethylene glycol-phosphatidylethanolamine is 2000, and 20mg of quercetin are dissolved in chloroform and methanol In 100ml of organic solvent, including 75ml of chloroform and 25ml of methanol, stir in a closed bottle until lecithin, cholesterol, polyethylene glycol-phosphatidylethanolamine and quercetin are completely dissolved, and place the completely dissolved solution in 250ml Connect the flask to a rotary evaporator, immerse the flask in a constant temperature water bath at 40°C, vacuum the rotary evaporation to remove the organic solvent, and form a uniform film on the wall of the flask, then put it into a vacuum drying oven, Dry at room temperature for 2 hours, add 100ml of sterilized water, ultrasonically disperse with an ultrasonic breaker, the power of the ultrasonic instrument is 200W, and the ultrasonic time i...
Embodiment 2
[0075] 0.50g lecithin, 0.10g cholesterol, 0.09g polyethylene glycol-phosphatidylethanolamine, the molecular weight of polyethylene glycol in polyethylene glycol-phosphatidylethanolamine is 3000, and 0.30g quercetin is dissolved in trichloro In 1L organic solvent of methane and methanol, the volume ratio of chloroform and methanol is v:v=1:1, stir in a closed bottle until lecithin, cholesterol, polyethylene glycol-phosphatidylethanolamine and quercetin Completely dissolve, put the completely dissolved solution in a 2.5L eggplant-shaped flask, connect the eggplant-shaped flask to a rotary evaporator, and immerse the flask in a constant temperature water bath at 30°C, vacuumize the rotary evaporation to remove the organic solvent, and form a circle on the wall of the flask Layer a uniform lipid film, then put it into a vacuum drying oven, dry it at room temperature for 2 hours, add 1L of sterilized water, and ultrasonically disperse it with an ultrasonic breaker, the ultrasonic po...
Embodiment 3
[0077] Dissolve 45mg of lecithin, 8mg of cholesterol, 8mg of polyethylene glycol-phosphatidylethanolamine, the molecular weight of polyethylene glycol in polyethylene glycol-phosphatidylethanolamine is 2000, and 35mg of quercetin are dissolved in chloroform and methanol 200ml In the organic solvent, the volume ratio of chloroform and methanol is v:v=4:1, and the volume is measured in milliliters or liters. Stir in a closed bottle until lecithin, cholesterol, polyethylene glycol-phosphatidylethanolamine Dissolve completely with quercetin, place the dissolved solution in a 500ml eggplant-shaped flask, connect the eggplant-shaped flask to a rotary evaporator, and immerse the flask in a constant temperature water bath at 35°C, and vacuum the rotary evaporation to remove the organic solvent. Form a uniform film on the surface, then put it into a vacuum drying oven, dry it at room temperature for 2 hours, add 200ml of sterilized water, and carry out ultrasonic dispersion with an ultr...
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