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Application of Jinbei oral liquid in anti-virus aspect

A technology of Jinbei oral liquid and antiviral drug, applied in the field of medicine, can solve the problem of lack of safe and reliable vaccine, and achieve the effect of reducing the virus titer in the body, good effect, and improving the antiviral ability of the body

Active Publication Date: 2018-06-22
SHANDONG UNIV OF TRADITIONAL CHINESE MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no safe and reliable vaccine available clinically and in the market

Method used

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  • Application of Jinbei oral liquid in anti-virus aspect
  • Application of Jinbei oral liquid in anti-virus aspect
  • Application of Jinbei oral liquid in anti-virus aspect

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] 1. Materials

[0038] 1.1 virus

[0039] RSV (respiratory syncytial virus) long strain, H1N1 (influenza virus).

[0040] 1.2 cells

[0041] See Table 1-1.

[0042] Table 1-1 Cells used and applicable viruses

[0043]

[0044] Note: The viruses and cells used in the experiment were provided by the Microbiology Laboratory of the Institute of Basic Medicine, Shandong Academy of Medical Sciences

[0045] 1.3 Main instruments

[0046] Biological safety cabinet (Thermo Company); low-temperature high-speed centrifuge (Hermle, Germany); ultra-clean workbench (Jinan Longhong Company); microplate reader (product of Leibo Company in Finland); inverted microscope (Olympus Company); Jinan Deqiang Instrument Co., Ltd. MJ37600); pure water machine (Jinan Taipingma Environmental Protection Co., Ltd.); CO 2 Cell constant temperature incubator (Japan Sanyang Company)

[0047] 1.4 Drugs

[0048] The prescription composition of Jinbei Oral Liquid is shown in Table 1-2. The Jinbe...

Embodiment 2

[0101] 1 material

[0102] 1.1 virus

[0103] RSV mouse lung isolates were preserved in the Microbiology Laboratory of Shandong Academy of Medical Sciences. After the virus was cultured and activated on Hep-2 cells, the supernatant was obtained by centrifugation after repeated freezing and thawing, and the half cell infection amount (TCID) on the cells was measured.50 ) is 10 -7 . 。2 / mL.

[0104] 1.2 Drugs

[0105] As described in Example 1.

[0106] 1.3 Experimental animals

[0107] BALA / c female mice, SPF grade, 6-8 weeks old, were purchased from the Experimental Animal Center of Shandong University, production license number SCXK (Lu) 20150001.

[0108] 1.4 Instruments

[0109] Biological safety cabinet (Jinan Xinbeixi Biotechnology Co., Ltd.); ultra-clean workbench (Jinan Longhong Company); microplate reader (product of Leibo Company in Finland); low-temperature high-speed centrifuge (He Lishi desktop low-temperature centrifuge); Inverted microscope (Olympus); aut...

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PUM

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Abstract

The invention belongs to the field of medicine, and in particular relates to application of Jinbei oral liquid in anti-virus aspect. The Jinbei oral liquid has an inhibitory effect on RSV and H1N1; the main mechanism of the antiviral action is to block the adhesion of viruses, that is, to play a preventive role, so that the preventive medication effect is better; the number and harm of the virusesduring the incubation period are not very large, so that the killing and elimination of the viruses are better facilitated, and the effect of getting twofold results with half the effort is achieved.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of Jinbei oral liquid in anti-respiratory virus. Background technique [0002] Respiratory viruses are important pathogens that cause respiratory diseases. Common clinical respiratory viruses include respiratory syncytial virus (RSV) and influenza virus (such as H1N1). [0003] Respiratory syncytial virus (RSV) belongs to the Paramyxoviridae family and is the main pathogen causing severe lower respiratory tract infections such as bronchitis, bronchial asthma and pneumonia in infants and young children. The clinical symptoms and severity of RSV infection in people of different age groups are quite different, among which the incidence rate is the highest and the condition is the most serious in people under 6 months old, and there will be a certain mortality rate if the treatment is not timely. Studies have shown that there is also a certain infection rate for a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8966A61K9/08A61P31/14A61P31/16
CPCA61K36/8888A61K36/8966A61K9/0095A61K36/23A61K36/232A61K36/236A61K36/344A61K36/355A61K36/481A61K36/484A61K36/537A61K36/539A61K36/634A61K2300/00
Inventor 闫滨邓华亮孟兆青王诗源张爱均李鹏高敏岳路路王丹丹
Owner SHANDONG UNIV OF TRADITIONAL CHINESE MEDICINE
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