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Anti-caking composite Carbasalate calcium powder agent and preparation method thereof

A technology of compound carbasalate calcium powder and carbasalate calcium, which is applied in anti-inflammatory agents, powder delivery, pharmaceutical formulations, etc., can solve problems affecting drug storage, stability and use performance, and easy moisture absorption and caking, etc., to achieve Inhibition of caking phenomenon, ensuring drug stability, high safety effect

Inactive Publication Date: 2018-06-29
ZHENGZHOU HOUYI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the structural characteristics of carbasalate calcium, it is easy to absorb moisture and agglomerate during storage, which affects the storage, stability and performance of the drug.
However, there are few reports on the anti-caking research of carbasalate calcium

Method used

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  • Anti-caking composite Carbasalate calcium powder agent and preparation method thereof
  • Anti-caking composite Carbasalate calcium powder agent and preparation method thereof
  • Anti-caking composite Carbasalate calcium powder agent and preparation method thereof

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Embodiment 1

[0011] An anti-caking compound carbasalate calcium powder consists of the following raw materials in parts by weight: 40-60 parts of carbasalate calcium, 25-49 parts of carrier, 1-25 parts of anti-caking agent; the carrier is β- One or two combinations of cyclodextrin, hydroxypropyl β-cyclodextrin, methylcellulose, ethylmethylcellulose, ethylcellulose, glucose; the anti-caking agent is isopropyl myristate One or a combination of esters, N,N-diethyl lauramide, magnesium silicate, magnesium chloride, magnesium aluminum silicate, stearamide, zinc stearate.

[0012] Preferred: the carrier is preferably a combination of β-cyclodextrin and methylcellulose, or a combination of hydroxypropyl β-cyclodextrin and methylcellulose; the anti-caking agent is preferably magnesium silicate and iso-myristate A combination of propyl esters or a combination of magnesium silicate and N,N-diethyllauramide.

[0013] The preferred formula is: 40-60 parts of carbasalate calcium, 15-20 parts of β-cycl...

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PUM

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Abstract

The invention discloses an anti-caking composite Carbasalate calcium powder agent which consists of the following raw materials in parts by weight: 40-60 parts of Carbasalate calcium, 25-49 parts of acarrier and 1-25 parts of an anti-caking agent, wherein the carrier is one or a combination of two of beta-cyclodextrin, hydroxypropyl beta-cyclodextrin, methylcellulose, ethylmethyl cellulose, ethyecellulose and glucose; the anti-caking agent is one or a combination of two of isopropyl myristate, N,N-diethyl lauramide, magnesium silicate, magnesium silicate, magnesium aluminosilicate, stearamideand zinc stearate. The anti-caking composite Carbasalate calcium powder agent disclosed by the invention is simple in component and high in security; the raw materials are all available in the marketand are cheap and easy to obtain; the caking phenomenon of Carbasalate calcium is effectively inhibited, and the storage and use properties of the Carbasalate calcium are improved; meanwhile, the medicinal stability of the Carbasalate calcium is ensured, and very high practical values can be made; in addition, the powder agent is simple in preparation process and can be prepared by simply mixingthe components together.

Description

technical field [0001] The invention relates to the field of veterinary medicine, in particular to veterinary drugs, in particular to an anti-caking compound carbasalate calcium powder and a preparation method thereof. Background technique [0002] Carbasalate calcium (earbasalatecaleium) is an aspirin derivative, and its curative effect is the same as that of aspirin, but it has low side effects, good water solubility, and better drug efficacy and physiological functions, so it has been widely valued. Due to the structural characteristics of carbasalate calcium, it is easy to absorb moisture and agglomerate during storage, which affects the storage, stability and performance of the drug. However, there are few reports on the anti-caking research of carbasalate calcium. Contents of the invention [0003] The present invention aims to overcome the existing technical defects of the above-mentioned technologies, and aims to provide a compound carbapirin calcium powder capabl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/222A61K47/14A61K47/18A61K47/02A61K47/12A61P29/00
CPCA61K9/143A61K9/145A61K9/146A61K31/222
Inventor 马沛然王凯李建正李亚娥
Owner ZHENGZHOU HOUYI PHARMA
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