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Application of extract of root of Hainan devilpepper in treating of ulcerative colitis in mice

A technology of extract and Rauvolfia, applied in the field of the role and mechanism of dextran sodium sulfate in mice colitis, can solve problems such as unclear

Inactive Publication Date: 2018-06-29
海南省人民医院
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AI Technical Summary

Problems solved by technology

People of the Li nationality in Hainan often use its root water decoction to treat high fever, insomnia, dizziness, bruises, sprains, and snake bites. It is believed that it has obvious anti-inflammatory effects, but whether it has a therapeutic effect on DSS-induced colitis in mice is not yet known Clearly, its function link and target need to be further elucidated

Method used

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Examples

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Effect test

Embodiment 1

[0014] Example 1 The mechanism of anti-inflammatory immune effect of Hainan Rauwolfia extract pectin polysaccharide in treating UC

[0015] 1. Materials

[0016]1. Animals: 80 female BALB / C mice aged 6-8 weeks, weighing 17-22g per mouse, purchased from the Experimental Animal Center of West China Medical Center, Sichuan University, raised in the Human Disease-Related Peptide Laboratory, and raised in rack cages , keep constant temperature (23 ± 1 ℃), constant humidity (humidity 50-60%), light and darkness alternately for 12 hours, eat sterilized standard feed, and use sterilized filtered water.

[0017] 2. Drugs and reagents: Hainan Rauvolwolfia, collected from Mount Diaoluo, Hainan. Sodium dextran sulfate (dextran sulfatesodium, DSS molecular weight 36000-50000), produced by Sigma. IL-4, IL-13 kits, produced by Gibco. Rabbit anti-human IκB-α polyclonal antibody (Cayman Chemical Company, USA), and the above reagents were provided by Chengdu Genna Biotechnology Co., Ltd.

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Abstract

The invention relates to the field of biomedicines, and in particular relates to an effect and a mechanism of extract of root of Hainan devilpepper on dextran sulfate sodium colitis in mice, and the extract can interfere with signaling pathways of NF-kB and MAPKs. The extract is obtained by drying the root of Hainan devilpepper at 40 DEG C, filtering with a 0.7% ammonium oxalate solution for extraction, centrifuging residue, adjusting pH to 4.40 with HCL, again centrifuging, precipitating the residue with ethanol, and drying after centrifugation.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to the effect and mechanism of the extract of Rauwolfia verticillata (Lour.) Baill.var.hainanensis Tsiang on dextransulphatesodium (DSS) mouse colitis. Background technique [0002] Ulcerative colitis (Ulcerative Colitis, UC) is a non-specific chronic inflammation of the intestinal tract, and its pathogenesis is still unclear. At present, it is considered to be related to genetics, environment and abnormal immune response, among which the abnormal local immune response of the intestinal mucosa and the imbalance of immune regulation are considered to be important links in its pathogenesis. The treatment of UC lacks specific and effective drugs. Traditional drugs such as salicylic acid drugs, glucocorticoids, and immunosuppressants have many side effects, unstable curative effect, and easy to relapse after drug withdrawal; long-term use of biological agents often causes intolerable adverse ...

Claims

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Application Information

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IPC IPC(8): A61K36/24A61P1/00A61P1/04A61P29/00
CPCA61K36/24A61K2236/331A61K2236/53
Inventor 苗新普孙晓宁崔路佳王裕宣李思琼
Owner 海南省人民医院
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