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A kind of traditional Chinese medicine composition for treating gastroesophageal reflux disease, traditional Chinese medicine granules and preparation method thereof

A technology for gastroesophageal reflux and traditional Chinese medicine granules, which is applied in the directions of drug combinations, pharmaceutical formulations, and medical preparations containing active ingredients, etc., to achieve the effects of good granulation difficulty, few medicinal flavors, and high extract yield.

Active Publication Date: 2020-10-16
SHANGHAI DERMATOLOGY HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, there is no report about the traditional Chinese medicine granules for the treatment of gastroesophageal reflux disease of the present invention and the preparation method thereof.

Method used

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  • A kind of traditional Chinese medicine composition for treating gastroesophageal reflux disease, traditional Chinese medicine granules and preparation method thereof
  • A kind of traditional Chinese medicine composition for treating gastroesophageal reflux disease, traditional Chinese medicine granules and preparation method thereof
  • A kind of traditional Chinese medicine composition for treating gastroesophageal reflux disease, traditional Chinese medicine granules and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Traditional Chinese medicine composition: 6 parts of Bupleurum, 12 parts of Citrus aurantium, 3 parts of Coptis chinensis, 3 parts of Evodia rutaecarpa, 9 parts of Jiaoshanzhi, 9 parts of Helicopteris, 12 parts of Magnolia officinalis, 15 parts of Polygonatum, and 15 parts of calcined corrugated fruit.

Embodiment 2

[0043] Traditional Chinese medicine composition: 7 parts of Bupleurum bupleuri, 13 parts of Citrus aurantii, 4 parts of Coptis chinensis, 4 parts of Evodia rutaecarpa, 8 parts of Jiaoshan Zhi, 8 parts of spinosa, 11 parts of Magnolia officinalis, 14 parts of Polygonatum, and 14 parts of calcined corrugated fruit.

Embodiment 3

[0045] Traditional Chinese medicine composition: 5 parts of Bupleurum, 11 parts of Citrus aurantium, 2 parts of Coptis chinensis, 2 parts of Evodia rutaecarpa, 10 parts of Jiaoshanzhi, 10 parts of Sinusia officinalis, 13 parts of Magnolia officinalis, 16 parts of Polygonatum, and 16 parts of calcined corrugated fruit.

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Abstract

The invention discloses a traditional Chinese medicine composition for treating a gastroesophageal reflux disease and traditional Chinese medicine granules as well as a preparation method thereof. Thetraditional Chinese medicine granules contain 100 parts by weight of traditional Chinese medicine extract, 50 parts by weight of dextrin and 8 parts by weight of ethanol solution. A traditional Chinese medicine extracting method comprises the following steps: taking 6 parts by weight of radix bupleuri, 12 parts by weight of fructus aurantii, 3 parts by weight of coptis chinensis, 3 parts by weight of fructus evodiae, 9 parts by weight of stir-baked fructus gardeniae, 9 parts by weight of herba inulae, 12 parts by weight of mangnolia officinalis, 15 parts by weight of rhizoma polygonati and 15parts by weight of calcined concha arcae, adding 10 times of water and extracting for three times, wherein the extracting time per time is 1.0 h; combining decoction liquid, filtering, concentratingand drying. The traditional Chinese medicine composition for treating the gastroesophageal reflux disease and the traditional Chinese medicine granules as well as the preparation method thereof disclosed by the invention have the benefits that an extraction process is optimized by adopting an orthogonal experiment method and a weighted analysis method, and the yield of optimized dry extracts and the contents of naringin and gardenin are determined, so that an optimum extraction process is obtained; a preparation process is further optimized by adopting a single-item screening method, and the molding rate, the solubility and the granulation difficulty of the granules prepared by the optimized process are investigated, so that an optimal preparation process is obtained.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating gastroesophageal reflux disease, traditional Chinese medicine granules and a preparation method thereof. Background technique [0002] Gastroesophageal reflux disease (GERD) is a common digestive tract motility disorder disease, which causes clinical gastroesophageal reflux disease and esophageal mucosa damage due to excessive exposure of the gastroesophageal lumen to gastric juice. Acid reflux, heartburn, retrosternal pain and other symptoms. The disease is very common in western countries. With the rapid development of my country's economy, people's living standards have improved, Chinese people's lifestyle and diet structure are gradually Westernized, and the population is aging. The prevalence of GERD is gradually increasing, and it is very easy to relapse. The goals of GERD treatment are to reliev...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8969A61K9/16A61P1/04A61K35/618
CPCA61K9/1652A61K35/618A61K36/233A61K36/28A61K36/575A61K36/718A61K36/744A61K36/752A61K36/754A61K36/8969A61K2236/331A61K2236/39A61P1/04A61K2300/00
Inventor 朱全刚陈中建柴蓉蓉朱聪聪潘会君安多朋谢辛欣张红敏
Owner SHANGHAI DERMATOLOGY HOSPITAL
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