The invention relates to a mailuoning granule and preparation method, wherein the mailuoning granule has the functions of clearing heat and nourishing yin and promoting blood circulation to remove blood stasis. The mailuoning granule comprises a mailuoning extract and polysaccharide, wherein the mailuoning extract is prepared by taking radix achyranthis bidentatae, scrophulariae, dendrobium and honeysuckle as raw materials. The mailuoning granule is clinically used for the coolness, soreness, numb, burning sensation, intermittent claudication, rest pain and the like of limb skin caused by stage-I and stage-II athero-sclerosis obliterans and thromboangitis obliterans, as well as local swelling, pain, skin temperature rise, skin color abnormality and the like caused by acute and subacute-stage deep vein thrombosis of the lower extremity, and hemiplegia, deviation of mouth and tongue, hemianesthesia, unsmooth speech and the like caused by mild and severe cerebral infarction in recovery phase. The mailuoning granule has the good pharmaceutical and biological properties.