Ginseng granule and preparation method

A technology of granules and ginseng, which is applied in the direction of anti-toxic agents, pharmaceutical formulas, medical preparations of non-active ingredients, etc., can solve problems such as the preparation method of granules for obtaining ginseng extract, and achieve the effect of reducing losses

Inactive Publication Date: 2020-11-24
HUAZHONG AGRICULTURAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In the granules prepared from a single medicinal extract as raw material, as in the Chinese patent application CN101653481A, a granule using Forsythia extract as a raw material has been prepared, but due to the matching of medicinal materials, it is also difficult to obtain it from the existing granulation process. The preparation method of granules suitable for ginseng extract, so that it has excellent comprehensive performance

Method used

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  • Ginseng granule and preparation method
  • Ginseng granule and preparation method
  • Ginseng granule and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Preparation of ginseng extract:

[0058] Weigh ginseng coarse powder, add distilled water according to the material-to-liquid ratio of 1:30, mix well, adjust the pH of the mixture to 4.7, add 0.6% pectinase, shake the water bath at 60°C for 4 hours, take out the boiling water bath for 5 minutes to inactivate the enzyme, and wait for cooling Centrifuge at 4°C, 8000r / min for 10min, and keep the supernatant. The bottom residue obtained by centrifugation was added to distilled water at a solid-to-liquid ratio of 1:50, extracted by flash homogenization at 2800r / min for 4 minutes, centrifuged to retain the supernatant, and combined with the enzymatic hydrolysis supernatant, and the resulting combined filtrate was the ginseng extract. The ginseng extract is concentrated by evaporation under reduced pressure to obtain an extract with a relative density of 1.20-1.30 at a temperature of 50-60°C.

[0059] The ginseng extracts used in the subsequent examples and comparative exampl...

Embodiment 2

[0061] The present embodiment provides the preparation method of ginseng granules, comprising the following steps:

[0062] S1, mix the ginseng extract and the selected excipients in proportion, after drying, use an appropriate amount of ethanol as a wetting agent to make a soft material, put it in a tray, mix evenly, hold it into a ball, lightly press it and then disperse Can;

[0063] S2, if it is necessary to prepare samples with flavoring agents added, after mixing the flavoring agents and soft materials, they are rolled and granulated by a rolling granulator (YK160), and then dried in a vacuum drying oven; If there is no need to add flavoring agent, the agglomerated granulated soft material without flavoring agent is directly rolled and granulated by a rolling granulator (YK160), and then placed in a vacuum drying oven to dry;

[0064] S3, whole grain.

[0065] Among them, in S1, drying is carried out at -100Kpa, 50°C, and in S2, the drying pressure is -100Kpa.

[0066...

Embodiment 3

[0081] Carry out product testing to each type of ginseng granules of embodiment 2 and comparative example 1 respectively, and the testing items are corresponding as follows:

[0082] 3.1 Test the molding rate of the granules of models S1-S12, S14, S22-S30 in Example 2 and the granules of models D1-D3 in the comparative example.

[0083] 3.2 Evaluate the comprehensive quality of S1, S3, and S5 excipients. The evaluation method is: three parallel measurements of the moisture absorption rate, dissolution rate, molding rate, angle of repose, and bulk density of the sample, and the results are used as various indicators to calculate the comprehensive score. Calculated as follows:

[0084] Comprehensive index = 15×forming rate / maximum forming rate+20×dissolving rate value / maximum dissolving rate value+15×bulk density value / maximum bulk density value+15×minimum angle of repose / angle of repose value+35×minimum moisture absorption value / Moisture absorption rate value, moisture absorp...

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Abstract

The invention relates to a ginseng granule and a preparation method thereof. The ginseng granule is prepared from the following preparation raw materials: a ginseng extract, an excipient, a wetting agent and a flavoring agent, wherein the weight ratio of the ginseng raw material corresponding to the ginseng extract to the excipient is 1: (1.45-2.0); the wetting agent is an ethanol solution with avolume percentage of 70%-90%; the ginseng granule is prepared from the preparation raw materials through a wet granulation process; the ginseng extract is the ginseng extract which is obtained by an enzymolysis synergistic high-speed homogenization method and subjected to concentrating at a temperature of 50-60 DEG C to obtain a ginseng extractum with a relative density of 1.20-1.30; and the excipient is one selected from the group consisting of soluble starch, beta-cyclodextrin and dextrin. Compared with the prior art, the ginseng granule has the following beneficial effects: the ginseng granule prepared by using the preparation method provided by the invention contains a variety of ginsenoside and polysaccharide components; meanwhile, the contents of the ginsenoside and polysaccharide components are high; and the ginseng granule is high in granule forming rate, low in hygroscopicity, excellent in flowability, good in solubility, good in antioxidant activity, good in oral sensory experience and stable in quality.

Description

technical field [0001] The invention belongs to the field of preparation of traditional Chinese medicines and health care products, and in particular relates to a ginseng granule and a preparation method thereof. Background technique [0002] Ginseng is a well-known traditional natural tonic in China. Its main functions are tonify Yuan and strengthen Yuan, restore pulse and solidify, nourish spleen and Qi, promote body fluid and soothe nerves, etc. Modern medical research shows that ginseng has a certain effect on maintaining the body's physiological activities, including improving the immune system, cardiovascular system, nervous system, and digestive system. Neuromodulation, immune regulation, anti-aging, antibacterial and hypoglycemic, etc., have very high application value in many aspects. [0003] Traditional Chinese medicine granules are often a new decoction-based dosage form that is made by extracting the main or single component of Chinese medicinal materials throu...

Claims

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Application Information

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IPC IPC(8): A61K36/258A61P39/06A61K9/16A61K47/36A23L33/105A23P10/25
CPCA23V2002/00A61K9/1652A61K9/1694A61K36/258A61K2236/19A23L33/105A23P10/25A61P39/06A23V2200/302
Inventor 李秀娟李风涛戴浩张晓伟
Owner HUAZHONG AGRICULTURAL UNIVERSITY
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