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Mailuoning granule and preparation method

A technology of Mailuoning and granules, applied in the field of Mailuoning granules and preparation methods, can solve the problems of inconvenience to carry, difficult to store, and inconvenient for clinical medication.

Active Publication Date: 2013-07-10
JIANGXI YINTAO PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The dosage form of oral liquid has disadvantages such as not easy to store, precipitation of bacteria prone to rancidity, inconvenient to carry, etc. Therefore, there are certain limitations in the use of Mailuoning oral liquid and injection, which brings inconvenience to clinical medication

Method used

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  • Mailuoning granule and preparation method

Examples

Experimental program
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Effect test

preparation example 1

[0156] Preparation example 1, the preparation of Mailuoning extract

[0157] Feeding and ratio of medicinal materials: Achyranthes bidentata 9.5kg, Scrophulariaceae 9.5kg, Dendrobium 9.5kg, Honeysuckle 9.5kg.

[0158] Soak the above-mentioned four-flavor medicinal materials in 6 times the weight of water for 2 hours, then decoct twice, each time for 1.5 hours, and filter; combine the filtrate after two decoctions; conduct the combined filtrate at 80°C Concentrate for the first time to obtain a concentrated solution with a relative density of 1.16g / ml; add ethanol to the concentration by weight of the alcohol content in the concentrated liquid after the first concentration to 66%, leave it for 12 hours, and carry out the first The operation of taking the supernatant for the second time; recovering ethanol in the supernatant obtained for the first time and concentrating for the second time at 80°C to obtain a concentrated solution with a relative density of 1.36g / ml: Concentrat...

preparation example 2

[0159] Preparation example 2, the preparation of Mailuoning extract

[0160] Feeding ratio of medicinal materials: Achyranthes bidentata, Scrophulariaceae, Dendrobium, honeysuckle=1:0.9:1.1:0.9; Achyranthes bidentata feeding 9.5kg.

[0161] Soak the above-mentioned four-flavor medicinal materials in 6 times the weight of water for 2 hours, then decoct twice, each time for 1.5 hours, and filter; combine the filtrate after two decoctions; conduct the combined filtrate at 80°C Concentrate for the first time to obtain a concentrated solution with a relative density of 1.16g / ml; add ethanol to the concentration by weight of the alcohol content in the concentrated liquid after the first concentration to 66%, leave it for 12 hours, and carry out the first The operation of taking the supernatant for the second time; recovering ethanol in the supernatant obtained for the first time and concentrating for the second time at 80°C to obtain a concentrated solution with a relative density...

preparation example 3

[0162] Preparation example 3, the preparation of Mailuoning extract

[0163] Feeding ratio of medicinal materials: Achyranthes bidentata, Scrophulariaceae, Dendrobium, honeysuckle=1:1.1:0.9:1.1; Achyranthes bidentata feeding 9.5kg.

[0164] Soak the above-mentioned four-flavor medicinal materials in 6 times the weight of water for 2 hours, then decoct twice, each time for 1.5 hours, and filter; combine the filtrate after two decoctions; conduct the combined filtrate at 80°C Concentrate for the first time to obtain a concentrated solution with a relative density of 1.16g / ml; add ethanol to the concentration by weight of the alcohol content in the concentrated liquid after the first concentration to 66%, leave it for 12 hours, and carry out the first The operation of taking the supernatant for the second time; recovering ethanol in the supernatant obtained for the first time and concentrating for the second time at 80°C to obtain a concentrated solution with a relative density...

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Abstract

The invention relates to a mailuoning granule and preparation method, wherein the mailuoning granule has the functions of clearing heat and nourishing yin and promoting blood circulation to remove blood stasis. The mailuoning granule comprises a mailuoning extract and polysaccharide, wherein the mailuoning extract is prepared by taking radix achyranthis bidentatae, scrophulariae, dendrobium and honeysuckle as raw materials. The mailuoning granule is clinically used for the coolness, soreness, numb, burning sensation, intermittent claudication, rest pain and the like of limb skin caused by stage-I and stage-II athero-sclerosis obliterans and thromboangitis obliterans, as well as local swelling, pain, skin temperature rise, skin color abnormality and the like caused by acute and subacute-stage deep vein thrombosis of the lower extremity, and hemiplegia, deviation of mouth and tongue, hemianesthesia, unsmooth speech and the like caused by mild and severe cerebral infarction in recovery phase. The mailuoning granule has the good pharmaceutical and biological properties.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine pharmacy, and relates to a Mailuoning granule, in particular to an oral Mailuoning granule prepared from Achyranthes bidentata, Scrophulariae, Dendrobium and Honeysuckle as raw materials, which has the functions of clearing away heat and nourishing yin, promoting blood circulation The effect of removing blood stasis can be used clinically for coldness, soreness, numbness, burning sensation, intermittent claudication, rest pain, etc. caused by stage I and II arteriosclerotic obliterans and thromboangiitis obliterans; Local swelling, pain, elevated skin temperature, abnormal skin color, etc. caused by deep vein thrombosis of the lower extremities in the subacute stage, and hemiplegia, tongue and tongue deviation, numbness of the side of the body, and speech impairment caused by mild to moderate cerebral infarction in the recovery stage. Background technique [0002] Cardiovascular and cer...

Claims

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Application Information

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IPC IPC(8): A61K36/8984A61K9/16A61K47/36A61P9/10A61P7/02
Inventor 刘炜
Owner JIANGXI YINTAO PHARMACEUTICAL CO LTD
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