Skin cuticle repair essence microcapsule and preparation method thereof

A technology of stratum corneum and essence, applied in skin care preparations, pharmaceutical formulas, cosmetic preparations, etc., can solve problems such as low utilization rate of cholesterol, unsatisfactory repair effect of stratum corneum barrier, etc., to improve skin Status, Effect of Acceleration Barrier Function

Inactive Publication Date: 2018-08-10
SUZHOU COSMETIC MATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] It is very important to repair the stratum corneum barrier with suitable physiological lipids in time, but in the prior art, due to problems such as absorption and penetration, the utilization rate of supplemented physiological lipid ceramide, cholesterol and other raw materials is low, which is harmful to The effect of repairing the stratum corneum barrier has not yet reached a satisfactory level

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] A skin cuticle repair essence microcapsule. The microcapsule is a transparent spherical soft capsule with a core-shell structure, wherein the capsule wall is a sericin shell membrane, and the capsule core is a skin cuticle repair essence. The mass ratio is 1:1, and the diameter of the microcapsule is 1mm; by weight, the skin stratum corneum repair essence includes: 11 parts of ceramide, 8 parts of cholesterol, 5 parts of lecithin, 3 parts of vitamin A, vitamin E 1 part, 1 part histidine, 1 part lysine, 1 part arginine, 3 parts hyaluronic acid, 3 parts sweet almond oil, 2 parts jojoba oil.

[0019] The preparation method of described skin stratum corneum repair essence microcapsule, described method comprises the following steps:

[0020] (1) Prepare a sericin solution containing 220mmol / L metal ions, adjust the pH to 6, and place it in a constant temperature box at 30°C for reaction after continuous stirring;

[0021] (2) Centrifuge the solution after the reaction in s...

Embodiment 2

[0027] A skin cuticle repair essence microcapsule. The microcapsule is a transparent spherical soft capsule with a core-shell structure, wherein the capsule wall is a sericin shell membrane, and the capsule core is a skin cuticle repair essence. The mass ratio is 2:1, and the diameter of the microcapsule is 3mm; by weight, the skin stratum corneum repair essence includes: 22 parts of ceramide, 15 parts of cholesterol, 14 parts of lecithin, 4 parts of vitamin A, vitamin E 5 parts, 2 parts histidine, 2 parts lysine, 2 parts arginine, 5 parts hyaluronic acid, 7 parts sweet almond oil, 6 parts jojoba oil.

[0028] The preparation method of described skin stratum corneum repair essence microcapsule, described method comprises the following steps:

[0029] (1) Prepare a sericin solution containing 240mmol / L metal ions, adjust the pH to 6.5, and place it in a thermostat at 35°C for reaction after continuous stirring;

[0030] (2) Centrifuge the solution after the reaction in step (1...

Embodiment 3

[0036] A skin cuticle repair essence microcapsule. The microcapsule is a transparent spherical soft capsule with a core-shell structure, wherein the capsule wall is a sericin shell membrane, and the capsule core is a skin cuticle repair essence. The mass ratio is 3:1, and the diameter of the microcapsule is 5mm; by weight, the skin stratum corneum repair essence includes: 28 parts of ceramide, 19 parts of cholesterol, 18 parts of lecithin, 7 parts of vitamin A, 8 parts of vitamin E 3 parts, 3 parts histidine, 3 parts lysine, 3 parts arginine, 9 parts hyaluronic acid, 11 parts sweet almond oil, 9 parts jojoba oil.

[0037] The preparation method of described skin stratum corneum repair essence microcapsule, described method comprises the following steps:

[0038] (1) Prepare a sericin solution containing 260mmol / L metal ions, adjust the pH to 7, and place it in a constant temperature box at 37°C for reaction after continuous stirring;

[0039] (2) Centrifuge the solution after...

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Abstract

The invention discloses a skin cuticle repair essence microcapsule and a preparation method thereof. The microcapsule is a transparent spherical soft capsule of a core-shell structure, wherein the capsule wall is a sericin shell membrane, the capsule core is a skin cuticle repair essence, the mass ratio of the capsule wall to the capsule core o is (1-3):1, and the diameter of the microcapsule is 1-5 mm; the skin cuticle repair essence comprises, by weight, 11-28 parts of ceramide, 8-19 parts of cholesterol, 5-18 parts of lecithin, 3-7 parts of vitamin A, 1-8 parts of vitamin E, 1-3 parts of histidine, 1-3 parts of lysine, 1-3 parts of arginine, 3-9 parts of hyaluronic acid, 3-11 parts of sweet almond oil and 2-9 parts of jojoba oil. All components of the skin cuticle repair essence microcapsules act synergistically to promote the absorption rate of ceramide, cholesterol and other raw materials; the microcapsule can be well integrated into intercellular space and accelerate recovery ofthe barrier function of the damaged skin cuticle, thereby improving the skin condition.

Description

technical field [0001] The invention belongs to the technical field of cosmetics and relates to a basic skin care essence, in particular to a skin cuticle repair essence microcapsule and a preparation method thereof. Background technique [0002] The stratum corneum is located in the outermost layer of the skin. Physiologically speaking, the stratum corneum provides an extremely effective barrier to prevent the loss of water inside the skin cells and the erosion of external microorganisms and chemical substances. Generally speaking, the stratum corneum is composed of 12 to 16 layers of flat, non-nuclear corneocytes that overlap and restrict each other. The lipid matrix is ​​sandwiched between each layer of corneocytes to form a unique structure of the stratum corneum. The main lipids in the stratum corneum include ceramide (40-50%), cholesterol (about 25%), free fatty acid (about 25%), cholesterol sulfate (about 5%) and a small amount of phosphoric acid. According to the la...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/02A61K8/64A61K8/68A61K8/63A61K8/55A61K8/67A61K8/44A61K8/49A61K8/73A61K8/92A61Q19/00
CPCA61K8/025A61K8/44A61K8/4946A61K8/553A61K8/63A61K8/64A61K8/671A61K8/678A61K8/68A61K8/735A61K8/922A61K2800/56A61K2800/592A61K2800/622A61K2800/652A61K2800/805A61Q19/00
Inventor 金仲恩全春兰张帆喻国贞欧阳智琨陈晋纳
Owner SUZHOU COSMETIC MATERIALS
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