Biological marker and method for diagnosing or estimating mortality risk

A biomarker and risk technology, applied in the field of diagnosis or estimation of death risk, can solve unclear problems

Active Publication Date: 2018-08-21
SHENZHEN YIKANG BIOTECH CO LTD
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Problems solved by technology

PGRMC1 contributes to tumorigenesis in a variety of tumors, including breast, ovarian

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  • Biological marker and method for diagnosing or estimating mortality risk
  • Biological marker and method for diagnosing or estimating mortality risk
  • Biological marker and method for diagnosing or estimating mortality risk

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Embodiment Construction

[0051] In order to describe the technical content, achieved goals and effects of the present invention in detail, the following descriptions will be made in conjunction with the embodiments and accompanying drawings.

[0052] The present invention describes the CYB5D2 molecular biological network composed of 4891 genes. According to a series of analyses, a set of characteristic gene combinations was obtained in the CYB5D2 molecular biological network. This set of characteristic gene combinations can be effectively used to predict the long-term survival and prognosis of breast cancer patients, and can also be used for different intrinsic subtypes of breast cancer, including luminal A and B, normal type, low Claudin protein type and basal cell type. This set of characteristic gene combinations includes 21 different genes for SigCYBDEGBC, 36 genes for SigCYBDEGBC1, 42 genes for SigCYBDEGBC2, 50 genes for SigCYBDEGBC3, 37 genes for SigCutpnt, 2 genes for SigBasal, and 4 genes for...

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Abstract

The invention relates to a biological marker and a method for diagnosing or estimating mortality risk. The biological marker comprises at least one group of the following characteristic genomes: SigCYBDEGBC, SigCYBDEGBC1, SigCYBDEGBC2, SigCYBDEGBC3, SigCutpnt, SigBasa1, SigClaudin, SigNorm, SigLumB and SingLumA. The biological marker has the advantage that forward survival and prognosis of breastcancer patients can be estimated effectively.

Description

technical field [0001] The invention relates to breast cancer detection technology, in particular to a biomarker that can be used to predict the death risk of breast cancer intrinsic subtype patients, and a method for diagnosing or estimating the death risk. Background technique [0002] According to the 2014 World Cancer Report (World Health Organization), breast cancer is the leading cause of cancer death in women worldwide. About 1.7 million women are diagnosed with breast cancer every year, and about 500,000 people die from breast cancer every year. Clinically, according to the expression of estrogen receptor and Her2 gene, breast cancer can be divided into three subtypes: estrogen receptor positive, Her2 positive and triple negative. Triple negative is the subclass of estrogen receptor, progesterone receptor and Her2 negative. Breast cancer can also be divided into six intrinsic subtypes based on gene expression profiles: luminal A and B (estrogen receptor positive), ...

Claims

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Application Information

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IPC IPC(8): C12Q1/6886C12N15/11
CPCC12Q1/6886C12Q2600/158C12Q2600/118
Inventor 唐大木何立智陈争陈婧赵坤成
Owner SHENZHEN YIKANG BIOTECH CO LTD
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