Method for preparing chlorinated-3-substituted-2,5-diphenyl tetrazole under catalysis of copper Lewis acid surfactant

A technology of diphenyltetrazolium and surfactant, which is applied in the field of organic synthesis, can solve the problems of high equipment quality requirements, complicated post-processing operations, and high production costs, and achieve reduced production equipment requirements, simple and easy operation and safety, The effect of simplification of reaction steps
CN108440433AActive Publication Date: 2018-08-24湖北佰智昂生物化工有限公司
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
湖北佰智昂生物化工有限公司
Publication Date
2018-08-24

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Abstract

The invention belongs to the technical field of organic synthesis and specifically relates to a method for preparing chlorinated-3-substituted-2,5-diphenyl tetrazole under the catalysis of a copper Lewis acid surfactant. The method comprises the following steps: 1) reacting benzaldehyde, phenylhydrazine, arylamine and sodium nitrite in solvent water by taking a copper Lewis acid surfactant Cu(OSO2CnH2n+1)2 as a catalyst to obtain 3-aryl-2,5-diphenylformazan; and 2) cyclizing and chlorinating 3-aryl-2,5-diphenylformazan in a mixed solvent of dichloromethane and water under the condition of a solid chlorination reagent N-chlorosuccinimide to obtain chlorinated-3-substituted-2,5-diphenyl tetrazole. By using the method, three-step conversion is completed according to a ''one-pot method'' continuous strategy, not only is an intermediate separation step omitted, but also the purification step is simple as well as convenient and easy to operate.
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Description

technical field

[0001] The invention belongs to the technical field of organic synthesis, and in particular relates to a method for preparing chlorinated-3-substituted-2,5-diphenyltetrazolium compounds by using a copper Lewis acid surfactant as a catalyst. Background technique

[0002] Chlorinated-3-substituted-2,5-diphenyltetrazolium compounds are widely used in the fields of biochemistry, pharmaceutical science, medicine, agriculture, high-energy materials, automobile industry and photography. Among them, 2,3,5-triphenyltetrazolium chloride (TTC for short) is often used as an analytical reagent and a chromatographic reagent, for example, it can be used to detect the vitality of seeds and the ischemic infarction of mammalian tissues. In addition, TTC can also be used as a corrosion inhibitor that mainly inhibits the anodic process, and is used to prevent the contact between the corrosive acidic solution and the steel surface and play a role in corrosion inhibition. Therefo...

Claims

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