Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of beta-caryophyllene in preparing medicine for preventing and treating external itching of skin

A technology of caryophyllene and drugs, which can be used in skin diseases, drug combinations, drug delivery, etc., and can solve problems such as antipruritics that have not yet been seen

Inactive Publication Date: 2018-09-11
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
View PDF1 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Existing studies suggest that the pharmacological studies of caryophyllene have antibacterial, anti-inflammatory, anti-fertility, termination of pregnancy, bone protection, and lowering blood sugar effects, but there is no report on itching

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of beta-caryophyllene in preparing medicine for preventing and treating external itching of skin
  • Application of beta-caryophyllene in preparing medicine for preventing and treating external itching of skin
  • Application of beta-caryophyllene in preparing medicine for preventing and treating external itching of skin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0013] Experiment 1 (Ointment antipruritic experiment)

[0014] 1 Experimental animals: 50 KM mice (purchased from the Experimental Animal Center of Guangzhou University of Traditional Chinese Medicine, animal certificate number: SCXK (Guangdong) 2013-0020), divided into 5 groups, 10 in each group, half male and half male, weight (22-28g).

[0015] 2 Itching substance: 4-aminopyridine (4-AP) physiological saline solution (injection volume is 1mg.kg -1 , The prepared sample concentration is 0.2mg.mL -1 ).

[0016] 3 Reagent: Diphenhydramine bulk drug (purchased from Henan Tianfu Chemical Co., Ltd., purity 99%), β-caryophyllene (purchased from sigma company, purity: 98.5%).

[0017] 4 Evaluation indicators: After administration for 20 minutes, immediately observe the latency time of the mouse body licking reaction and the number of licking times (administration site or shaved area) within 10 minutes. The body licking time over 3 seconds is counted twice.

[0018] 5 Sample preparation

[0...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
boiling pointaaaaaaaaaa
Login to View More

Abstract

The invention relates to an application of beta-caryophyllene in preparing medicine for preventing and treating external itching of skin, as a sole active ingredient. The medicine in this applicationconsists of beta-caryophyllene and other ingredients accepted by iatrology. The mass percentage content of caryophyllene in the medicine is 1.5%-6%. The medicine has the effects of preventing and treating skin itching, and can be used for preventing and treating itching of skin.

Description

Technical field [0001] The invention relates to medical products containing organic active ingredients, in particular to drugs containing bicyclic sesquiterpenoids. Background technique [0002] The main causes of itchy skin are mosquito bites, eczema, sweat rash, drug allergies, senile skin itching, or skin allergies caused by certain medical diseases, among which mosquito bites cause dermatitis. Itching can be regarded as a weakened pain. It has been established that itching and pain are transmitted by different nerve pathways and are caused by different mechanisms. However, the mechanism of itching has not been fully elucidated, and it is mainly considered to be histamine and bradykinin in the body. Endogenous stimulating substances such as proteases and proteases interact with multiple stimulus-responsive nerve terminals (itch receptors) that exist at the epidermis-dermis boundary, and the resulting impulses are transmitted along the spinothalamic tract, thalamus, and cerebra...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/015A61K9/06A61P17/04
CPCA61K9/0014A61K9/06A61K31/015A61P17/04
Inventor 王振华杜勤武肖云张志强
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com