Compound anti-cancer drug
An anti-cancer drug and drug technology, applied in the field of biomedicine, can solve problems such as unsatisfactory treatment methods, individual differences in curative effect, drug resistance, recurrence rate, etc., and achieve the effect of inducing apoptosis and differentiation, good inhibitory effect, and low price
Inactive Publication Date: 2018-10-16
WUYI UNIV
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Problems solved by technology
However, this treatment method is not ideal for non-APL AML patients, and the main treatment drugs are Cytarabine (Cytarabine) drugs
Even though breakthroughs have been made in the clinical treatment of acute myeloid leukemia, due to individual differences in efficacy, drug resistance, relapse rate and other refractory conditions, the development of low-toxic and effective drugs has become the key to controlling and reducing leukemia mortality. a major challenge
Method used
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Embodiment 1
[0014] A compound anticancer drug, the drug is composed of 12-oxo-tetradecanoylphorbol-13-acetate (TPA) and diethyldithiocarbamate with a mass ratio of 1:100 Ester (DTC) composition.
Embodiment 2
[0016] A compound anticancer drug, the drug is composed of 12-oxo-tetradecanoylphorbol-13-acetate (TPA) and diethyldithiocarbamate with a mass ratio of 1:250 Ester (DTC) composition.
Embodiment 3
[0018] A compound anticancer drug, the drug is composed of 12-oxo-tetradecanoylphorbol-13-acetate (TPA) and diethyldithiocarbamate with a mass ratio of 1:500 Ester (DTC) composition.
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The invention relates to a compound anti-cancer drug. The drug consists of diethyl dithiocarbamate (DTC) and 12-oxo-tetradecanoyl phorbol-13-acetate (TPA). The novel anti-cancer drug, through combinedapplication of the phorbol compound (TPA) and the dithiocarbamate compound (DTC), can achieve an effect of conducting optimal treatment on cancers, with efficacy better than that of individual drugs,and a good inhibitory effect can be achieved on myeloid leukemia; in addition, the compound drug, in cancer treatment, is low in administration dosage and lower in administration concentration than individual drugs, so that toxic and side effects of the drug are reduced and harm to human body is relieved; and the compound anti-cancer drug is relatively low cheap, so that economic burden of patients is reduced.
Description
technical field [0001] The invention relates to the technical field of biomedicine, in particular to a composite anticancer drug. Background technique [0002] Cancer is a serious threat to people's lives and health. The latest edition of the "World Cancer Report" released by the World Health Organization (WHO) in 2014 predicts that cancer cases will show a rapid increase, from 14 million in 2012 to 19 million in 2025. million, and will reach 24 million by 2035. With the increase of people's life and work pressure and the change of diet structure, the probability of people suffering from cancer has increased significantly. The latest cancer status released by the National Cancer Center in 2017 shows that about 10,000 people are diagnosed with cancer every day in the country, and the incidence rate ranks 74th in the world. , the number of morbidity ranks first in the world; the death rate ranks 29th in the world. Cancer has seriously threatened the quality of life and life ...
Claims
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Patent Timeline
Login to View More IPC IPC(8): A61K31/27A61K31/23A61P35/02
CPCA61K31/23A61K31/27A61P35/02A61K2300/00
Inventor 马于然郑希李冬利张焜段庆
Owner WUYI UNIV
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