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Auxiliary nutritive oral liquid for treating cancer

An oral liquid and nutrition technology, applied in the directions of non-active ingredients medical preparations, drug delivery, anti-tumor drugs, etc., can solve the problems of disulfiram instability, loss of function, fixation, etc., to optimize the anti-cancer effect, promote Generate and widen the effect of the adaptation range

Inactive Publication Date: 2018-10-30
HUNAN UNIV OF ARTS & SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The study found that disulfiram drugs, combined with copper in the human body, are metabolized into another substance, which accumulates in tumor cells and binds to the NLP4 protein, causing it to be immobilized and lose its function
[0003] However, after oral administration of disulfiram, disulfiram is extremely unstable in gastric acid, and most of the oral disulfiram is rapidly degraded into carbon disulfide and diethylamine, which prevents the therapeutic dose of the drug from reaching the cancer site

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The auxiliary nutritional oral liquid for treating cancer is prepared from the following raw materials in parts by weight: 9 parts of disulfiram, 5 parts of soluble pearl powder, 10 parts of Bletilla striata, 20 parts of radish seedlings, 15 parts of Dendrobium candidum, 15 parts of wheat germ, birch 10 parts of skin, 8 parts of detoxified honey.

[0021] The preparation method comprises the steps of:

[0022] (1) Grind bletilla striata, birch bark, and dendrobium officinale with a pulverizer, mix, then add 5-8 times the weight of pure water to mix, then add it to a multi-functional extraction tank, and heat it to 90-95°C with steam And keep it warm for 30 minutes, stir during the heating process, then filter the residue with a filter cloth, and cool the mixed filtrate 1 for subsequent use;

[0023] (2) Mix and soak wheat germ with an appropriate amount of water, pulverize it with a colloid mill, then enzymolyze the pulverized wheat germ suspension with glucoamylase + ...

Embodiment 2

[0027] The auxiliary nutritional oral liquid for treating cancer is prepared from the following raw materials in parts by weight: 11 parts of disulfiram, 5 parts of pearl powder, 8 parts of bletilla striata, 20 parts of radish seedlings, 10 parts of dendrobium candidum, 20 parts of wheat germ, and birch bark 10 servings.

[0028] The preparation method comprises the steps of:

[0029] (1) Grind bletilla striata, birch bark, and dendrobium officinale with a pulverizer, mix, then add 5-8 times the weight of pure water to mix, then add it to a multi-functional extraction tank, and heat it to 90-95°C with steam And keep it warm for 30 minutes, stir during the heating process, then filter the residue with a filter cloth, and cool the mixed filtrate 1 for subsequent use;

[0030] (2) Mix and soak wheat germ with an appropriate amount of water, pulverize it with a colloid mill, then enzymolyze the pulverized wheat germ suspension with glucoamylase + cellulase, and then filter to obt...

Embodiment 3

[0034] The auxiliary nutritional oral liquid for treating cancer is prepared from the following raw materials in parts by weight: 6 parts of disulfiram, 7 parts of pearl powder, 8 parts of bletilla striata, 25 parts of radish seedlings, 15 parts of dendrobium officinale, and 15 parts of wheat germ.

[0035] The preparation method comprises the steps of:

[0036] (1) Grind Bletilla striata and Dendrobium candidum with a pulverizer, mix them, then add 5-8 times the weight of pure water to mix, then add them to a multi-functional extraction tank, heat to 90-95°C with steam and keep warm for 30 minutes, Stir during the heating process, then filter the residue with a filter cloth, and the resulting mixed filtrate 1 is cooled for later use;

[0037] (2) Mix and soak wheat germ with an appropriate amount of water, pulverize it with a colloid mill, then enzymolyze the pulverized wheat germ suspension with glucoamylase + cellulase, and then filter to obtain filtrate 2, which is set asi...

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PUM

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Abstract

The invention discloses an auxiliary nutritive oral liquid for treating cancer and a preparation method thereof, wherein the oral liquid is mainly prepared from the following materials in parts by weight: 6-11 parts of disulfiram, 5-7 parts of pearl powder, 8-10 parts of bletilla striata, 20-25 parts of turnip sprouts, 10-15 parts of dendrobium officinale and 15-20 parts of wheat germ. According to the invention, by reasonable formula, the amount of disulfiram decomposed by gastric acid is reduced, the generation of cancer cell targeted substance is promoted, the amount of disulfiram initiatoris reduced, and the anti-cancer effect is optimized.

Description

technical field [0001] The invention relates to the technical field of functional nutritional products, in particular to an auxiliary nutritional oral liquid for treating cancer. Background technique [0002] Disulfiram is a drug commonly used as a drug for alcohol withdrawal. Even if you drink a small amount of alcohol after taking this drug, your body will experience severe discomfort in order to achieve the purpose of alcohol withdrawal. However, an international research team led by scientists from the Institute of Molecular and Translational Medicine of Palacky University in Olomouc, Czech Republic, discovered in the study that the alcohol withdrawal drug "Disulfiram" has anti-cancer properties. Studies have found that disulfiram drugs are combined with copper in the human body and are metabolized to produce another substance. This substance accumulates in tumor cells and binds to the NLP4 protein, causing it to be fixed and lose its function. [0003] However, after o...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/145A61K47/46A61P35/00
CPCA61K9/0053A61K31/145A61K47/46A61P35/00
Inventor 杨品红谢中国王芙蓉
Owner HUNAN UNIV OF ARTS & SCI
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