The invention provides a wear-resistant flame-retardant cable sheath compound, which contains the following raw materials in parts by weight: 75-80 parts of PVC resin, 15-22 parts of vinyl chloride-acetate copolymer, 13-18 parts of polyvinylidene fluoride, 8-12 parts of neoprene, 13-15 parts of butadiene-acrylonitrile rubber, 5-8 parts of butadiene styrene rubber, 3-9 parts of butadiene rubber, 10-12 parts of fiberglass, 8-14 parts of carboxymethyl cellulose, 1-3 parts of carbon black, 1-3 parts of white carbon black, 1.5-2 parts of talcum powder, 0.5-1.8 parts of zinc oxide, 1.5-2 parts of magnesium oxide, 5-8 parts of nano calcium carbonate, 5-8 parts of Nano-Si powder, 5-7 parts of Nano-xuancheng stone, 6-12 parts of Insect repellent, 5-10 parts of sulphur, 5-10 parts of Tertiary stearic acid, 6-12 parts of pitch, 14-16 parts of composite flame retardant, 15-19 parts of filler, and 1-3 parts of plasticizer. By taking a mixture of PVC resin, butadiene styrene rubber, butadiene-acrylonitrile rubber, EPDM rubber, neoprene and butadiene rubber as a base material, the wear-resistant flame-retardant cable sheath compound is excellent in flame-retardant performance; by adding other rawmaterials including composite flame retardant and the anti-aging agent, the anti-aging performance and flame-retardant performance of cables can be obviously enhanced, and the service life of the cable can be greatly prolonged.