Application of licorisoflavan A in preparation of drugs for treating depression

A technology for licorice isoflavane A and depression, which is applied in drug combinations, pharmaceutical formulas, and medical preparations containing active ingredients, etc., can solve problems such as no research on licorice isoflavane A, and shorten immobility time Effect

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A technology for licorice isoflavane A and depression, which is applied in drug combinations, pharmaceutical formulas, and medical preparations containing active ingredients, etc., can solve problems such as no research on licorice isoflavane A, and shorten immobility time Effect

CN108743580AActive Publication Date: 2018-11-06南京道尔医药科技有限公司

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Examples

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Embodiment 1

[0022] Example 1: Study on TST Experiment of Glycyrrhizae Isoflavan A on Mice

[0023] 1. Experimental method

[0024] The FST experiments in mice were administered continuously for 4 days, and administered once a day by intragastric administration. Behavioral tests were performed 1 h after the last administration. Each drug treatment was divided into control group, licorice isoflavan A (gastric administration) different dosage groups (20, 40, 60mg / kg, gastric administration) and imipramine hydrochloride tablet group (positive control group, 18mg / kg, orally administered). 10 mice per group. Put the mice into a circular glass container with a height of 20 cm, a diameter of 12 cm, and a water depth of 10 cm, at a water temperature of 25° C., observe for 6 min, and record the cumulative immobility time after 4 min. The criterion for judging immobility is that the animal stops struggling in the water and is in a floating state, with only small limb movements to keep the head ...

Embodiment 2

[0027] Example 2: Study on the FST Experiment of Glycyrrhizae Isoflavan A on Mice

[0028] 1. Experimental method

[0029] The FST experiments in mice were administered continuously for 4 days, and administered once a day by intragastric administration. Behavioral tests were performed 1 h after the last administration. Each drug treatment was divided into control group, licorice isoflavan A (gastric administration) different dosage groups (20, 40, 60mg / kg, gastric administration) and imipramine hydrochloride tablet group (positive control group, 18mg / kg, orally administered). 10 mice per group. The tail suspension box is 25×25×25 cm, and the center rope of the top plate is connected with a small clip. Stick the adhesive tape to the tail end of the mouse at 2 cm, clamp the adhesive tape with the clip, and make the mouse hang upside down, with the head about 2 cm away from the bottom of the tail suspension box. 5cm, observe for 6min, and record the cumulative immobility tim...

Embodiment 3

[0032] Example 3: Study on the Regulation of Glycyrrhizae Isoflavan A on Mouse AMPA Receptor and BDNF-TrkB Signaling Pathway

[0033] 1. Experimental grouping

[0034] Select healthy male mice with an initial weight of 25-28g, and feed them adaptively for 1 week. During this period, sugar water training and opening experiments are carried out. The Morris water maze is used to screen the mice for learning and memory 1 day before modeling, with two rounds within 1 min. Those who find the platform are qualified, otherwise they will be eliminated. Mice were randomly divided into normal control group (normal drinking and eating, without any stimulation), CUMS model group, CUMS+licorice isoflavan A group (40mg / kg), CUMS+imipramine hydrochloride group, 10 in each group. Strictly control the feeding conditions and keep the temperature and humidity constant. Oral administration before stress every morning.

[0035] 2. Establishment of chronic stress model in mice

[0036] For 24 cons...

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Abstract

The invention discloses application of licorisoflavan A in preparation of drugs for treating depression. Licorisoflavan A is a flavonoid compound separated from a Chinese herb, namely radix glycyrrhizae; the immobilization time of a mouse forced swimming test and tail suspension test of a chronic unpredictable mild stress depression model can be obviously shortened, it is indicated that licorisoflavan A has an excellent anti-depression effect, and by regulating and controlling AMPA receptors, a BDNF-TrkB passage can be adjusted to achieve the anti-depression effect. Licorisoflavan A can be combined with auxiliary agents, used for preparing the drugs for treating depression and applied with other anti-depression drugs.

Description

technical field [0001] The invention relates to the application of licorice isoflavan A, an active ingredient of the traditional Chinese medicine licorice, in the preparation of medicines for treating depression, and belongs to the field of traditional Chinese medicines. Background technique [0002] Depression, also known as "emotional cold", is a common emotional disorder mental disease, characterized by a significant and persistent low mood, clinical manifestations of depressed mood, loss of various interests and happiness, and often Accompanied by physical symptoms such as abnormal sleep, loss of appetite, weight loss, loss of libido, and even extreme behaviors such as suicide. With the intensification of competition, the incidence of depression is increasing, and it has gradually become a major disease that plagues human beings. According to WHO prediction, depression will become the second largest human disease by 2020, accounting for 5.7% of the total disease burden,...

Claims

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Application Information

Patent Timeline

06 Nov 2018

Publication

CN108743580A

IPC: A61K31/353; A61P25/24

CPC: A61K31/353; A61P25/24

Inventors: 王琦; 成小兰