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A kind of application of radiotherapy sensitization nanometer material

A technology of nanomaterials and uses, which is applied in the field of radiosensitization nanomaterials, can solve the problem of insensitivity of tumor cells to chemotherapeutic drugs or radiotherapy, and achieve the effect of improving radiotherapy curative effect, good application prospects, and improving oxygenation status

Active Publication Date: 2021-01-29
SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Abstract
  • Description
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Problems solved by technology

In addition, the hypoxic microenvironment further enhances the malignancy of tumors, resulting in insensitivity of tumor cells to chemotherapeutic drugs or radiotherapy

Method used

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  • A kind of application of radiotherapy sensitization nanometer material
  • A kind of application of radiotherapy sensitization nanometer material
  • A kind of application of radiotherapy sensitization nanometer material

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Experimental program
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Embodiment 1

[0025] A kind of Na provided by the invention 2 CO 3 •H 2 o 2 @HMS-Fe 3 o 4 The preparation method of the composite material is as follows:

[0026] 1. Preparation of composite mesoporous silica nanoparticles (HMS):

[0027] Dissolve 2 g of cetyltrimethylammonium chloride and 0.08 g of triethanolamine in 20 mL of deionized water, heat and stir to 95°C. Then 1 g of ethyl orthosilicate was added dropwise to the above solution, and the stirring was continued for 1 h. Then, a mixed solution of 1 g tetraethoxyethyl orthosilicate and 2 g bis-[3-(triethoxysilyl)propyl]-tetrasulfide was added to the above solution, and the stirring was continued for 4 h. Afterwards, after centrifugation, washing with water and alcohol, and removing the surfactant in the mesopores with an acidic ethanol solution, the composite mesoporous silica nanoparticles HMS can be obtained.

[0028] In the present invention, cetyltrimethylammonium chloride CTAC is first used as a surfactant, and CTAC is us...

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Abstract

The invention discloses the use of a radiation-sensitizing nanomaterial, which is a silicon oxide composite material loaded with sodium percarbonate and iron oxide nanoparticles, which is denoted as H-HMS-Fe, and the H-HMS-Fe Can be used for radiosensitization. The H-HMS-Fe prepared by the present invention utilizes the EPR effect of the nanomaterial itself to achieve passive targeting of tumor tissue, and then generates oxygen around the solid tumor tissue to improve the oxygenation state of the tumor tissue, thereby achieving the purpose of radiosensitization, It has a good application prospect.

Description

technical field [0001] The invention belongs to the field of medical materials, and in particular relates to the application of radiotherapy-sensitizing nanomaterials. Background technique [0002] The hypoxic microenvironment is an important feature of solid tumors. Under hypoxic conditions, tumor cells secrete a variety of angiogenic growth factors to promote the formation of abnormal blood vessels. At the same time, in order to find a more suitable soil, the invasion and metastasis ability of tumor cells will be further improved. In addition, the hypoxic microenvironment further enhances the malignancy of tumors, making tumor cells insensitive to chemotherapeutic drugs or radiation therapy. The hypoxic microenvironment is an important factor for the poor prognosis of tumors. In this microenvironment, tumor growth, metastasis, and resistance to drugs and radiation therapy are greatly enhanced. [0003] Therefore, improving the tumor hypoxic microenvironment is expected...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/51A61K47/02A61K47/04A61P35/00
CPCA61K9/5115A61P35/00
Inventor 郝永强符静珂贺超
Owner SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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