Flexible microneedle sensor and its preparation method, three-dimensional three-dimensional electrode and package thereof

A three-dimensional, sensor technology, used in instruments, measuring devices, scientific instruments, etc., can solve problems such as difficulty in detecting human tissue fluid, and achieve the effects of shortening detection response time, avoiding infection, and improving instrument detection accuracy.

Active Publication Date: 2019-08-09
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The technical problem to be solved by the present invention is to overcome the current difficult situation of human tissue fluid detection and provide a detection device suitable for long-term or multiple use, which can minimally invasively intervene in human body tissue fluid components

Method used

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  • Flexible microneedle sensor and its preparation method, three-dimensional three-dimensional electrode and package thereof
  • Flexible microneedle sensor and its preparation method, three-dimensional three-dimensional electrode and package thereof
  • Flexible microneedle sensor and its preparation method, three-dimensional three-dimensional electrode and package thereof

Examples

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Effect test

no. 1 approach

[0073] In the first embodiment of the present invention, a flexible microneedle sensor is provided, and the sensor includes: one or more needle parts;

[0074] base part,

[0075] The one or more needle parts are connected to the base part, and the other end of each needle part has a sharp structure,

[0076] The needle body part includes a matrix and electrodes encapsulated inside the matrix, the electrodes are three-dimensional electrodes, and the needle body matrix includes at least partially cross-linked water-soluble or hydrophilic polymer materials.

[0077] 3D Stereo Electrode

[0078] The three-dimensional electrode in the present invention refers to an electrode with a three-dimensional structure in space, and such an electrode can have one or more states of topology, comb, dendrite or spiral pyramid in three-dimensional space .

[0079] The three-dimensional three-dimensional structure can provide more reaction surfaces for the electrode. For example, after the ...

no. 2 approach

[0110] In the second embodiment of the present invention, a method for preparing a flexible microneedle sensor is provided. The sensor includes one or more needle parts and a base part. The needle part includes a matrix and a three-dimensional structure inside the matrix. A three-dimensional electrode, the method comprising the steps of:

[0111] Preparation steps of three-dimensional three-dimensional electrodes;

[0112] A step of encapsulating the three-dimensional electrode with a matrix to form a needle part;

[0113] The step of connecting one end of the needle part to the base part, and the matrix of the needle part comprises at least partially cross-linked water-soluble or hydrophilic polymer material.

[0114] The composition and form of the needle part, the base part, and the three-dimensional electrode are the same as those in the above-mentioned first embodiment of the present invention.

[0115]For the preparation of three-dimensional three-dimensional electrode...

no. 3 approach

[0118] In the third embodiment of the present invention, the present invention provides a three-dimensional three-dimensional electrode and its preparation method. The three-dimensional three-dimensional electrode has a bottom and a top, and forms a continuous spiral cone along the direction from the bottom to the top. shape; in the vertical direction from the bottom to the top, the longest distance between the bottom and the top is 500-1200 microns; in the vertical direction from the bottom to the top, the bottom has a maximum width of 200-600 microns in the projected area ; The three-dimensional three-dimensional electrode is formed by curable resin and a conductive layer formed on the surface of the curable resin.

[0119] The electrode with spiral cone shape has a hollow structure, its outline is formed by a spiral resin strip or wire, and the bottom of the cone shape has a circular, elliptical or similar projected outline. And the electrodes optionally can be surface modi...

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Abstract

The invention relates to a flexible micro-needle sensor and a preparation method thereof, a three-dimensional electrode and a packaging body thereof. The sensor comprises: one or more needle parts; and a substrate part. The one or more needle parts are connected to the substrate part, and the other end of each needle part has a sharp structure. Each needle part comprises a matrix and an electrodeencapsulated in the matrix. The electrode is a three-dimensional electrode, and the matrix of the needle part includes an at least partially crosslinked water-soluble or hydrophilic polymer material.

Description

technical field [0001] The invention relates to the field of preparation of electrochemical sensors, and proposes a design concept and preparation method of a flexible microneedle electrochemical sensor, which is especially suitable for real-time detection and analysis of chemical components of human tissue fluid for a long time without pain. Background technique [0002] Clinically, the detection and diagnosis of many diseases need to be achieved by collecting blood samples or other body fluids. The analysis and detection process and equipment are often expensive and cumbersome, and can only be carried out in hospitals, which is not conducive to self-monitoring and management of patients at home. Moreover, the process of repeated blood collection will not only bring great physical and mental pain to the patient, but also easily cause wound infection. Taking diabetics as an example, the most common way to detect blood sugar is to use a fingertip blood glucose meter to comple...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/327G01N33/50
CPCG01N27/3271G01N33/50
Inventor 冯雪梁紫微鲁思渊
Owner TSINGHUA UNIV
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