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Traditional Chinese medicine preparation for treating pain and preparation method thereof

A technology of traditional Chinese medicine preparation and pain syndrome, which is applied in the field of extraction, separation and application of traditional Chinese medicine, which can solve the problems of unsuitability for large-scale industrial production, high production cost, and complicated extraction method, and achieve simple and easy operation, low production cost, and convenient clinical practice Applied effect

Inactive Publication Date: 2018-12-18
广西维威制药有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Hu Shuping studied the organic acid components of Chinese peach leaves and developed ointment. He used ion exchange chromatography and modern separation technology to determine the optimal extraction process of total organic acids, and conducted pharmacological research. However, the extraction method is complicated and the production cost is high. Not suitable for industrialized mass production
The present invention further studies the effective active ingredients of Chinese peach leaves for relieving pain, screens out more effective pain relieving effective parts and an extraction method suitable for large-scale production by optimizing the extraction and purification method, and prepares it into a tincture. At present, there is no relevant report

Method used

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  • Traditional Chinese medicine preparation for treating pain and preparation method thereof
  • Traditional Chinese medicine preparation for treating pain and preparation method thereof
  • Traditional Chinese medicine preparation for treating pain and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The preparation method of the effective part of walnut leaf comprises the following steps:

[0028] S1. Get 5 kg of Han peach leaf medicinal material, grind it into coarse powder, soak it with 5 kg of 5% sodium bicarbonate solution for 20 minutes, then use 6 times the amount of 30 ethanol to heat and reflux to extract 2 times, each time for 1 hour, filter to obtain the initial filtrate;

[0029] S2. Put the primary filtrate in a cold storage at 0-4°C for 24 hours, filter, and recover ethanol from the filtrate to obtain an extract;

[0030] S3. Add 4 times the amount of water to the extract, mix well, and adjust the pH value of the solution to 3 with hydrochloric acid solution;

[0031] S4. Extract twice with water-saturated n-butanol solution, recover n-butanol from the extract under reduced pressure, dry, and obtain the extract that is the effective part of Chinese peach leaves.

[0032] The preparation method of embodiment 1 Chinese peach leaf tincture:

[0033] Wi...

Embodiment 2

[0035] The preparation method of the effective part of walnut leaf comprises the following steps:

[0036] S1. Get 5kg of Chinese peach leaf medical material, be ground into coarse powder, soak 30 minutes with 6kg of 5% sodium bicarbonate solution, then use 8 times the amount of 40% ethanol to heat and reflux extract 3 times, each time for 2 hours, filter to obtain primary filtrate;

[0037] S2. Put the primary filtrate in a cold storage at 0-4°C for 48 hours, filter, and recover ethanol from the filtrate to obtain an extract;

[0038] S3. Add 6 times the amount of water to the extract, mix well, and adjust the pH value of the solution to 4 with sulfuric acid solution;

[0039] S4. Extract 3 times with water-saturated n-butanol solution, recover n-butanol from the extract under reduced pressure, dry, and the obtained extract is the effective part of Chinese peach leaf.

[0040] The preparation method of embodiment 2 Han peach leaf tincture:

[0041] With the preparation met...

Embodiment 3

[0043] The preparation method of the effective part of walnut leaf comprises the following steps:

[0044] S1. Get 5 kg of Chinese peach leaf medicinal material, grind it into coarse powder, soak it with 5.5 kg of 5% sodium bicarbonate solution for 25 minutes, then use 7 times the amount of 35% ethanol to heat and reflux to extract 2 times, each time for 1.5 hours, filter, get primary filtrate;

[0045] S2. Put the primary filtrate in a cold storage at 0-4°C for 32 hours, filter, and recover ethanol from the filtrate to obtain an extract;

[0046] S3. Add 5 times the amount of water to the extract, mix well, and adjust the pH value of the solution to 3.5 with hydrochloric acid solution;

[0047] S4. Extract 3 times with water-saturated n-butanol solution, recover n-butanol from the extract under reduced pressure, dry, and the obtained extract is the effective part of Chinese peach leaf.

[0048] The preparation method of embodiment 3 Han peach leaf tincture:

[0049] With t...

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Abstract

The invention discloses a traditional Chinese medicine preparation for treating pain. A preparation method for the traditional Chinese medicine preparation comprises the following steps: picking a schefflera kwangsiensis leaf medicinal material, crushing the schefflera kwangsiensis leaf medicinal material, soaking with a 5% sodium bicarbonate solution, heating, reflowing and extracting with 30-40%alcohol, filtering, standing filtrate for 24-48 hours in a refrigeration house at temperature of 0-4 DEG, filtering, recycling alcohol to obtain extract after decompressing filtrate, adding water, uniformly mixing, using acid to regulate the pH value of the solution to be 3-4, using a water saturated n-butyl alcohol solution to extract, recycling n-butyl alcohol by decompressing extracting solution to obtain extract, adding 50% alcohol, glycerol and laurocapram to uniformly mix, and filtering to obtain the traditional Chinese medicine preparation. The schefflera kwangsiensis effective part with the pain relieving effect is prepared into a tincture, so that external use of a patient is convenient, a pain state of the patient can be locally improved, and clinical application is convenient.The invention provides the preparation method for the traditional Chinese medicine preparation for treating pains, and the preparation method is simple and easy in operation, is high in effective partextracting yield, is strong in operability, is low in production cost, and is suitable for industrial large-scale production.

Description

technical field [0001] The invention relates to the technical field of extraction, separation and application of traditional Chinese medicines, in particular to a traditional Chinese medicine preparation for treating pain and a preparation method thereof. Background technique [0002] Pain is a common clinical symptom, and the complications of many diseases are accompanied by pain, which brings great pain to patients. The commonly used analgesics in clinical practice refer to the drugs that can relieve pain partially or completely, including non-steroidal anti-inflammatory drugs and central analgesics. Common painkillers include aspirin, painkillers, paracetamol, phenylbutazone, rofecoxib, etc. However, long-term use will increase gastrointestinal reactions and nephrotoxicity, and cause severe adverse reactions, which is not conducive to the treatment and recovery of patients' diseases. Some anesthetics are addictive, so they cannot be used for a long time. Traditional Chi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/25A61K9/08A61P29/00A61P25/02A61P19/02A61P19/06A61K127/00
CPCA61K9/0014A61K9/08A61K36/25A61K2236/333A61K2236/55A61P19/02A61P19/06A61P25/02A61P29/00
Inventor 韦天宝黄智波
Owner 广西维威制药有限公司
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