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Application of a pharmaceutical composition in the preparation of antiviral drugs

A composition and drug technology, which can be used in drug combinations, antiviral agents, and resistance to vector-borne diseases, etc., can solve problems such as general antiviral efficacy, large side effects, and virus resistance.

Active Publication Date: 2021-09-14
深圳市新鸿镁医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, most of the antiviral drugs used to treat upper respiratory tract infection are synthetic drugs, such as ribavirin and oseltamivir, etc., which may cause drug resistance of the virus during long-term use, resulting in mediocre antiviral efficacy , and side effects

Method used

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  • Application of a pharmaceutical composition in the preparation of antiviral drugs
  • Application of a pharmaceutical composition in the preparation of antiviral drugs
  • Application of a pharmaceutical composition in the preparation of antiviral drugs

Examples

Experimental program
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preparation example Construction

[0030] Further, the preparation method of the pharmaceutical composition comprises:

[0031] Mix the mixed medicinal materials formed by fennel fennel and spiny beans with 70-100% ethanol solution according to the ratio of solid to liquid: 1:15-25 and reflux extraction for 2-4 times, each time for 0.5-1.5h, concentrate the obtained extract, dry Dry.

[0032] Preferably, the temperature of reflux extraction is 60-80°C, or 65-75°C, or 70°C.

[0033] Preferably, the ratio of solid to liquid is 1:17~24, or 1:19~22, or 1:20.

[0034] Preferably, the concentration of the ethanol solution is 80-100%, or 90-100%, or 95%.

[0035] Preferably, extract 2~3 times, each time 0.8~1.2h; or extract 3 times, each time 1h.

[0036] This embodiment also provides a liquid preparation for treating viral upper respiratory tract infection, which is prepared by mixing the above pharmaceutical composition with sterile water to form a 5-500 g / L medicinal liquid and filtering it.

[0037] Preferably...

Embodiment 1

[0041] This embodiment provides a pharmaceutical composition, which comprises fennel fennel and Oxytropis falciparum at a mass ratio of 1:1.

[0042] The preparation method of this pharmaceutical composition comprises:

[0043] The fennel and Oxytropis falciparum were mixed at a mass ratio of 1:1, and mixed with 95% ethanol at a solid-to-liquid ratio of 1:20, and refluxed at 70°C for 3 times, 1 hour each time. The supernatant is recovered, concentrated, dried, and pulverized to obtain the obtained product.

Embodiment 2

[0045] The present embodiment provides a pharmaceutical composition, which comprises fennel and Oxytropis falciparum at a mass ratio of 1:5.

[0046] The preparation method of this pharmaceutical composition comprises:

[0047] Mix fennel and Oxytropis falciparum at a mass ratio of 1:5, and with absolute ethanol at a solid-to-liquid ratio of 1:15, and extract twice at 80°C under reflux, each time for 1.5h. The supernatant is recovered, concentrated, dried, and pulverized to obtain the obtained product.

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Abstract

The invention provides an application of a pharmaceutical composition in the preparation of antiviral drugs, which belongs to the field of medicines. The medicinal composition is an extract obtained by mixing and extracting the fennel fennel and the thorn bean with a mass ratio of 1:0.2-5. The medicinal composition is a mixed extract of fennel fennel and thorn bean, has better antiviral effect, can be used for preparing antiviral medicine or medicine for upper respiratory tract infection, and has wide application prospect.

Description

technical field [0001] The invention relates to the field of medicines, in particular to the application of a pharmaceutical composition in the preparation of antiviral medicines. Background technique [0002] Upper respiratory tract infection is called upper respiratory tract infection for short, also known as common cold. It is a general term including acute inflammation of the nasal cavity, pharynx or larynx, 70-80% of which are caused by viral infections, including influenza virus, rhinovirus, coronavirus, adenovirus, influenza and parainfluenza virus, respiratory syncytial virus, echo virus, Coxsackie virus, etc. [0003] At present, most of the antiviral drugs used to treat upper respiratory tract infection are synthetic drugs, such as ribavirin and oseltamivir, etc., which may cause drug resistance of the virus during long-term use, resulting in mediocre antiviral efficacy , And the side effects are large. In view of this, this patent is proposed. Contents of the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/66A61P31/12A61P11/00A61P31/16A61K36/48
CPCA61K36/48A61K36/66A61K2236/333A61K2236/39A61P11/00A61P31/12A61P31/16A61K2300/00Y02A50/30
Inventor 陈行平陶燕铎江磊
Owner 深圳市新鸿镁医疗器械有限公司
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