Application of bear gall dropping pills in preparation of antiviral drugs

A technology of antiviral drugs and bile dripping pills, applied in the directions of antiviral agents, pill delivery, pharmaceutical formulations, etc.

Pending Publication Date: 2020-04-17
SHANGHAI KAIBAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report about the application of Xiongdan dripping pills in the preparation of antivira...

Method used

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  • Application of bear gall dropping pills in preparation of antiviral drugs
  • Application of bear gall dropping pills in preparation of antiviral drugs
  • Application of bear gall dropping pills in preparation of antiviral drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment one: the preparation of Xiongdan dripping pills

[0019] Xiongdan dripping pills were prepared according to the preparation method in the invention patent application 200410040574.8. The raw material bear bile powder used in the present invention is the dried bile of black bears or brown bears.

[0020] The present embodiment takes the preparation of Xiongdan dripping pills as an example, and the steps are as follows:

[0021] 1. Preparation of bear bile powder

[0022] Take the bear bile, dry it, crush it, and store it in a desiccator for future use.

[0023] 2. Preparation of Xiongdan Dropping Pills

[0024] (1) Add bear bile powder into melted polyethylene glycol 6000 or polyethylene glycol 4000 matrix, stir well, drop into drop pills, drain the coolant to obtain final product;

[0025] (2) The mechanisms used include but are not limited to polyethylene glycol 4000, polyethylene glycol 6000, sodium stearate, gelatin;

[0026] (3) The coolant used incl...

Embodiment 2

[0028] Example 2: Effects on Influenza A Virus-induced Mouse Infection Model

[0029] 1. Materials

[0030] 1.1 Experimental animals

[0031] 1.1.1 Basic situation

[0032] (1) Animal strain: Babl / C mouse.

[0033] (2) Age: 4-6 weeks old.

[0034] (3) Gender: half male and half male

[0035] (4) Weight range: 16-18g.

[0036] (5) Source: Shanghai Lingchang Biotechnology Co., Ltd.

[0037] (6) Grade: SPF grade.

[0038] (7) Laboratory animal production license number: Laboratory animal quality certificate number: 2013001832987.

[0039] 1.1.2 Animal grouping method:

[0040] After the quarantine, the mice qualified for quarantine observation were selected and randomly divided into 6 groups according to body weight and gender balance: negative control group (31 mice / group), model group (38 mice / group), and low-dose Xiongdan dripping pills. group (36 rats / group), Xiongdan Dripping Pills low-dose group (37 rats / group), Xiongdan Dripping Pills high-dose group (38 rats / grou...

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Abstract

The invention discloses application of bear gall dropping pills in preparation of antiviral drugs. Through animal experiments on the influence of the bear gall dropping pill on a mouse influenza A virus infection model, the applicant accidentally finds that the bear gall dropping pill can prolong the survival time of animals, improve the survival rate of the animals, reduce the lung index and reduce the pulmonary lesion rate, so that the application prospect of the bear gall dropping pill in preparation of antiviral drugs is revealed.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to the application of Xiongdan dripping pills in the preparation of antiviral drugs. Background technique [0002] Bear bile, obtained from the dried gallbladder bile of black bears or brown bears, has the effects of clearing away heat, calming the liver, and improving eyesight. Its main component is tauroursodeoxycholic acid (TUDCA). Bear bile is one of the four famous and precious animal medicines. It has a history of more than 2,000 years of use, and a large number of prescriptions contain bear bile. [0003] The dosage form of current existing bear bile powder is bear bile capsule, which is recorded in "The Ministry of Health of the People's Republic of China Drug Standards Chinese Medicine Prescriptions Volume 13". Currently, it is generally processed into common capsules for use, and the bioavailability is low. Clinically, an efficient and convenient dosage form is requir...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K35/413A61P31/16A61P31/12
CPCA61K35/413A61K9/2031A61P31/16A61P31/12
Inventor 张小利穆竟伟王国明
Owner SHANGHAI KAIBAO PHARMA
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