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Pharmaceutical composition for treating pneumonia

A composition and drug technology, applied in the field of medicine, can solve the problems of changing the clinical symptoms of pneumonia, quickly improving inflammatory reactions, reducing mortality, etc., achieving major economic and social benefits, broad prospects for industrialization, and reducing lung index Effect

Active Publication Date: 2021-10-26
WEST CHINA HOSPITAL SICHUAN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, antimicrobial treatment alone cannot significantly and quickly improve the inflammatory response, but inhibiting the production of pro-inflammatory cytokines can change the clinical symptoms of pneumonia and reduce mortality

Method used

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  • Pharmaceutical composition for treating pneumonia
  • Pharmaceutical composition for treating pneumonia
  • Pharmaceutical composition for treating pneumonia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Example 1 Preparation of the pharmaceutical compositions of the invention embodiment common tablet

[0040] Of compound A + B mass ratio of 1: 1 powder 100g, addition of a pharmaceutically acceptable starch 200g, both mixed to prepare 1000 tablets each weighing 0.3g.

Embodiment 2

[0041] Preparation of the pharmaceutical compositions of the invention Example 2 This injection

[0042] Of compound A + B mass ratio of 1: 1 powder 20g, 1,2-propylene glycol was added 100mL, sufficiently dissolved, add sterile water for injection is diluted to 1000mL, dispensed into 1,000 ampules after mixing, each lmL.

Embodiment 3

[0043] Example 3 Preparation of a pharmaceutical composition of the invention embodiment of a spray

[0044] Of compound A + B mass ratio of 1: 1 powder 20g, 1,2-propylene glycol was added 100mL, sufficiently dissolved, add sterile water for injection is diluted to 1000mL, dispensed to 1,000 spray bottle after mixing, each lmL.

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PUM

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Abstract

The invention relates to a pharmaceutical composition for treating pneumonia and belongs to the technical field of medicines. The provided pharmaceutical composition for treating pneumonia contains a compound A or a salt thereof and a compound B or a salt thereof. Pharmacological experiment results show that the pharmaceutical composition can significantly inhibit pneumonia caused by infection of viruses, bacteria, mycoplasmas and the like, reduce a lung index of infected mice, reduce inflammatory factors such as TNF-alpha, IL-8, IL-10 and IL-17, and improve a level of IFN-gamma, which indicates that the composition has a strong anti-pneumonia effect.

Description

Technical field [0001] The present invention relates to a pharmaceutical composition for treating pneumonia, belonging to the field of medical technology. Background technique [0002] Pneumonia is an important disease threat to human health, morbidity and mortality are high. Viruses, bacteria, mycoplasma infection is the leading cause of pneumonia. For example, Mycoplasma pneumoniae is interposed between the bacterial and viral pathogens, Mycoplasma pneumoniae pneumonia, pulmonary inflammation that is caused by Mycoplasma pneumoniae, a common acquired pneumonia. Immune injury is important in the pathogenesis of mycoplasma infection. Mycoplasma pneumoniae pneumonia will also cause a variety of pulmonary complications, such as encephalitis, myocarditis, hepatitis and blood system diseases, causing great harm to the human body. [0003] Studies have shown that cytokines can induce microbial toxins, the combination of inflammatory mediators, initiate signal transduction pathways in ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/522A61K31/122A61P31/04A61P31/14A61P31/16A61P31/00A61P11/00
CPCA61K31/522A61K31/122A61P31/04A61P31/14A61P31/16A61P31/00A61P11/00A61K2300/00
Inventor 黄文张伯礼李幼平张俊华
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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