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Preparation method and application of biological agent with no drug resistance

A biological agent and drug resistance technology, applied in the field of new medicine, can solve the problems of poor treatment effect and slow effect of urticaria, and achieve the effect of durability, quick effect and small side effects

Inactive Publication Date: 2019-01-01
JIESHOU ZHAOLONG FOOD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, traditional Chinese medicine is also used for the treatment of urticaria. Traditional Chinese medicine is mostly used for oral Chinese medicine liquid. This kind of oral Chinese medicine takes effect slowly and has no good therapeutic effect on sudden urticaria.

Method used

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  • Preparation method and application of biological agent with no drug resistance

Examples

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Comparison scheme
Effect test

Embodiment 1

[0024] A method for preparing a drug-resistant biological agent, comprising the following steps:

[0025] (1) Mix the raw materials of traditional Chinese medicine evenly, put them in a steamer and steam them for 40 minutes under the conditions of 60°C and 0.3 MPa, sterilize them with ultraviolet lamp after steaming, crush them into powders with a crusher after sterilization, and add powder weight to the powders 12% deionized water, put in -5 ℃ and freeze for 3 hours, after freezing, naturally warm up to room temperature, and dry the powder;

[0026] (2) Add ethanol that is 12 times the weight of the powder to the above powder, soak for 2 hours, reflux extraction for 3 hours, centrifuge, collect the first filtrate and the first precipitate, add the first precipitate to ethanol that is 8 times its weight, and reflux extraction 1h, centrifugal filtration, collecting the second filtrate, combining the first filtrate and the second filtrate, concentrating under reduced pressure to...

Embodiment 2

[0029] A method for preparing a drug-resistant biological agent, comprising the following steps:

[0030] (1) Mix the raw materials of traditional Chinese medicine evenly, put them in a steamer and steam them at 80°C and 0.4MPa for 50 minutes. After steaming, sterilize them with ultraviolet lamp irradiation. 15% deionized water, put in -5 ℃ and freeze for 4 hours, after freezing, naturally warm up to room temperature, and dry the powder;

[0031] (2) Add ethanol 15 times the weight of the powder to the above powder, soak for 3 hours, reflux extraction for 4 hours, centrifuge, collect the first filtrate and the first precipitate, add the first precipitate to ethanol 10 times its weight, and reflux extraction 2h, centrifuging, collecting the second filtrate, combining the first filtrate and the second filtrate, concentrating under reduced pressure to recover ethanol, and preparing the primary liquid medicine;

[0032] (3) Sterilize the primary syrup by autoclaving for 50 minute...

Embodiment 3

[0036] A method for preparing a drug-resistant biological agent, comprising the following steps:

[0037] (1) Mix the raw materials of traditional Chinese medicine evenly, put them in a steamer and steam them for 45 minutes under the conditions of 70°C and 0.3 MPa, sterilize them with ultraviolet light after steaming, crush them into powders with a crusher after sterilization, and add the weight of powders to the powders 13% deionized water, put in -5 ℃ and freeze for 3 hours, after freezing, naturally warm up to room temperature, and dry the powder;

[0038] (2) Add ethanol 13 times the weight of the powder to the above powder, soak for 3 hours, reflux extraction for 3 hours, centrifuge, collect the first filtrate and the first precipitate, add the first precipitate to 9 times the weight of ethanol, and reflux extraction 1h, centrifugal filtration, collecting the second filtrate, combining the first filtrate and the second filtrate, concentrating under reduced pressure to rec...

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Abstract

The invention discloses a preparation method and application of a biological agent with no drug resistance, which relates to the field of novel medicine. The preparation method comprises the followingsteps: uniformly mixing Chinese herb raw materials, cooking in a steamer, then sterilizing by virtue of the radiation of an ultraviolet lamp, crushing by using a crushing machine into powder, freezing, adding ethanol, reflux extracting, centrifugally filtering, collecting first filtrate and first precipitates, adding the first precipitates, reflux extracting, centrifugally filtering, collecting second filtrate, mixing the first filtrate and the second filtrate, sterilizing by using a hot pressing sterilizing method, uniformly mixing the mixed filtrate and activation aid, continuously sterilizing by using the hot pressing sterilizing method, adding water for syringe, stirring, centrifugally filtering, and thus obtaining the biological agent. The prepared biological agent is high in drug effect, small in side effect and capable of being used for treating acute urticaria.

Description

Technical field: [0001] The invention relates to the field of new medicines, in particular to a method for preparing a drug-resistant biological agent and its application. Background technique: [0002] Various forms of preparations that use various types of carbon-based organisms with medical research value as raw materials, using traditional technology or modern biotechnology, and acting on the prevention (health care), treatment and diagnosis of various physiological symptoms of the human body are collectively referred to as biological preparations. [0003] Urticaria is commonly called as wheal rash. It is a localized edema reaction due to the dilation and increased permeability of small blood vessels in the skin and mucosa. It usually subsides within 2 to 24 hours, but new rashes occur repeatedly. The course of disease protracted for several days to several months. Clinically more common. The basic damage is wheal on the skin. Often have skin pruritus first, then wh...

Claims

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Application Information

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IPC IPC(8): A61K36/888A61K47/02A61K47/08A61K47/10A61K47/18A61K47/26A61K47/28A61K47/36A61P17/00A61P37/08A61K35/64
CPCA61K35/63A61K35/64A61K36/232A61K36/287A61K36/288A61K36/34A61K36/42A61K36/484A61K36/489A61K36/535A61K36/58A61K36/73A61K36/752A61K36/804A61K36/86A61K36/888A61K47/02A61K47/08A61K47/10A61K47/183A61K47/26A61K47/28A61K47/36A61K2236/333A61K2236/39A61P17/00A61P37/08A61K2300/00
Inventor 王启标
Owner JIESHOU ZHAOLONG FOOD
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