A bactericidal medical ultrasonic coupling agent and preparation method thereof

Abstract

The invention belongs to the field of medicine and hygiene, and in particular relates to a bactericidal medical ultrasonic coupling agent and a preparation method thereof. The ultrasonic coupling agent is mainly made of the following raw materials in weight percentage: carbomer 0.1-2.0%, wetting agent 2-20%, triethanolamine 0.1-1.0%, bactericide 0.5-2.0%, solubilizer 0.06-1.50% , Tween-800.5-1.0% and water 73-96%. The invention uses protocatechualdehyde and triclosan as the main bactericidal components, which have a synergistic effect and can significantly improve the overall bactericidal effect of the coupling agent, and the added solubilizer can significantly increase the effective content of triclosan in the aqueous solution , greatly improving the bactericidal effect of the overall couplant.

Description

technical field [0001] The invention belongs to the field of medicine and hygiene, and in particular relates to a bactericidal medical ultrasonic coupling agent and a preparation method thereof. Background technique [0002] When ultrasonic waves are incident on the boundary between two different media, the greater the difference in impedance between the two, the greater the reflection coefficient, and the less sound energy that passes through the interface into another medium. For medical ultrasound, if the probe is in "dry contact" with the skin, the ultrasonic waves emitted by the probe cannot enter the human body at all due to the strong reflection of the air layer between the two. Substance to expel the air and form a channel for the smooth and undistorted transmission of ultrasonic waves. This substance is called medical ultrasonic coupling agent. Since the ultrasonic coupling agent is directly coated on the skin surface and in direct contact with the probe, in additi...

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Problems solved by technology

[0003] Chinese patent application CN105983107A discloses a novel medical disinfection and sterilization ultrasonic coupling agent, which uses magnolol as the main rapid disinfection and sterilization component, and syringic acid, anisic acid, dipotassium glycyrrhizinate and vanillin as synergistic components. Through prescription compounding, the efficiency of disinfection and sterilization in ultrasonic detection can be improved, the cytotoxicity, skin irritation and sensitization of medical ultrasonic coupling agents can be reduced, and problems such as cross-infection in clinical ultrasonic instrument inspection can be avoided. However, the invention mainly uses As the bactericidal active ingredient, plant extracts have low stability and low bactericidal rate, and the bactericidal effect needs to be improved

However, in practical application, triclosan belongs to low toxicity according to toxicological acute toxicity grading standards, and the prescribed dosage should not exceed 0.3%. It is difficult to kill pathogenic microorganisms in a short time (3min) when used alone, and the bactericidal effect cannot reach Require

Moreover, the compatibility between triclosan and water-based polymer gel preparations is poor, resulting in agglomeration and turbidity of sterilized products, which affects the quality and use effect of products

[0005] In addition, when the couplant is used in winter, it will easily cause skin discomfort due to the low temperature. During use, a heating device is often used to heat or keep warm, and the operation is cumbersome.

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