A kind of protective agent for mitochondrial function of weaned piglets

A weaned piglet and protective agent technology, which is applied in animal husbandry, additional food elements, animal feed, etc., can solve the problems of excessive degradation of mitochondria, insufficient repair of body damage, and cell energy metabolism disorders, etc., and achieve the effect of convenience

Active Publication Date: 2021-08-03
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the compensatory mitophagy caused by weaning stress is not enough to repair the body damage caused by weaning stress. So far, there has been no report on how to alleviate weaning stress by regulating mitochondrial function and mitophagy.
However, mitophagy is also a double-edged sword. Excessive or disordered mitophagy can lead to excessive degradation of mitochondria in cells, causing cellular energy metabolism disorders, and even cell death.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment l

[0022] The prepared sodium-based montmorillonite is a sodium-based montmorillonite with a mass purity of 92%, a blue absorption amount of 42g / 100g, and a particle size (D50) of 6um.

[0023] Take 0.3 kg of ellagic acid, 0.3 kg of curcumin, 0.3 kg of syringin, and 3 kg of sodium montmorillonite and mix well to obtain a protective agent of mitochondrial function in weaned piglets (PMF) . The addition amount in piglet feed is 0.03wt.%.

[0024] A total of 108 21-day-old “Du×Long×Da” weaned piglets with an average body weight of 6kg were selected and randomly divided into 6 groups: control group, ellagic acid group, curcumin group, syringin group, and sodium-based montmorillonite group. Stone group, PMF group. The control group was fed conventional piglet feed, the ellagic acid group was fed piglet feed supplemented with ellagic acid, the curcumin group was fed piglet feed supplemented with curcumin, the syringin group was fed piglet feed supplemented with syringin, sodium montm...

Embodiment 2

[0029] The prepared sodium-based montmorillonite is a sodium-based montmorillonite with a mass purity of 93%, a blue absorption amount of 46g / 100g, and a particle size (D50) of 8um.

[0030] Take 1.5 kg of ellagic acid, 2 kg of curcumin, 1.3 kg of syringin, and 15 kg of sodium montmorillonite and mix well to obtain a protective agent of mitochondrial function inweaned piglets (PMF) . The addition amount in piglet feed is 0.02wt.%.

[0031]A total of 108 28-day-old “Du×Long×Da” weaned piglets with an average body weight of 7kg were selected and randomly divided into 6 groups: control group, ellagic acid group, curcumin group, syringin group, and sodium-based montmorillonite group. Stone group, PMF group. The control group was fed conventional piglet feed, the ellagic acid group was fed piglet feed supplemented with ellagic acid, the curcumin group was fed piglet feed supplemented with curcumin, the syringin group was fed piglet feed supplemented with syringin, sodium montmori...

Embodiment 3

[0036] The prepared sodium-based montmorillonite is a sodium-based montmorillonite with a mass purity of 91%, a blue absorption amount of 51g / 100g, and a particle size (D50) of 9um.

[0037] Take 0.5 kg of ellagic acid, 0.6 kg of curcumin, 0.5 kg of syringin, and 6 kg of sodium montmorillonite and mix well to obtain a protective agent of mitochondrial function in weaned piglets (PMF) . The addition amount in piglet feed is 0.05wt.%.

[0038] 108 23-day-old “Du×Chang×Jia” weaned piglets with an average body weight of 6.46 kg were selected and randomly divided into 6 groups, namely: control group, ellagic acid group, curcumin group, syringin group, and sodium-based Mongolian group. Tuolith group, PMF group. The control group was fed conventional piglet feed, the ellagic acid group was fed piglet feed supplemented with ellagic acid, the curcumin group was fed piglet feed supplemented with curcumin, the syringin group was fed piglet feed supplemented with syringin, sodium montmo...

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PUM

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Abstract

The invention discloses a protective agent for mitochondrial function of weaned piglets, which comprises the following components: 0.3-1.5 parts by weight of ellagic acid, 0.3-2 parts by weight of curcumin, 0.3-1.3 parts by weight of syringin, and 3-3 parts by weight of sodium montmorillonite 15 parts by weight. Compared with the single addition of ellagic acid, curcumin, syringin and sodium montmorillonite in the feed, the protective agent for mitochondrial function of weaned piglets of the present invention significantly improves the content of mitochondrial DNA in the intestinal tract and liver of post-weaned piglets, and the mitochondrial respiratory chain. Complex IV activity, expression of mitophagy marker proteins PINK1, Parkin, and LC3II / LC3I. Ellagic acid, curcumin, syringin, and sodium montmorillonite have significant interactions in improving intestinal and liver mitochondrial function and mitophagy levels, and have a positive synergistic combination effect. The protective agent for mitochondrial function of weaned piglets of the present invention can significantly improve the mitochondrial autophagy levels of the intestinal tract and liver after weaning through the synergistic effect of various components, and greatly improve the mitochondrial functions of the intestinal tract and liver after weaning.

Description

technical field [0001] The invention relates to an agent for protecting mitochondrial function of weaned piglets. Background technique [0002] The early weaning technology of piglets has been widely used in the contemporary pig industry, because early weaning of piglets can not only shorten the reproductive cycle of sows, increase the number of sows' annual farrowing and the utilization rate of farrowing pens, but also reduce the vertical transmission of maternal diseases to piglets , improving piglet health and growth performance. However, the digestive system of early weaned piglets is immature, and weaning stress often leads to digestive dysfunction, weakened disease resistance, growth retardation, and even death of weaned piglets, causing significant economic losses to the pig industry. [0003] Weaning of piglets induces complex morphological and functional changes involving nutrition, digestion and metabolism, stress, neuroendocrine, gene function, etc. Weaning is t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A23K50/30A23K50/60A23K20/10A23K10/30A23K20/28
CPCA23K10/30A23K20/10A23K20/28A23K50/30A23K50/60
Inventor 胡彩虹曹舒婷冯杰王春春肖勘宋泽和
Owner ZHEJIANG UNIV
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