Oral emulsion containing ganoderma lucidum spore oil and ganoderan and preparation method and application of oral emulsion

A technology of Ganoderma lucidum spore oil and Ganoderma lucidum polysaccharide, applied in the direction of medical preparations containing active ingredients, anti-toxins, pharmaceutical formulas, etc., can solve the problems of poor curative effect of Ganoderma lucidum, limited oral absorption, etc., and achieve the goal of improving oral bioavailability Effect

Inactive Publication Date: 2019-04-19
SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The ratio of Ganoderma lucidum triterpenoids and Ganoderma polysaccharides in Ganoderma lucidum medicinal materials from different origins ranges from 1:2.84-2.91:1. Within this ratio range, Ganoderma lucidum triterpenes and Ganoderma polysaccharides can synergistically exert the best curative effect. limit, leading to poor curative effect of taking Ganoderma lucidum directly

Method used

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  • Oral emulsion containing ganoderma lucidum spore oil and ganoderan and preparation method and application of oral emulsion
  • Oral emulsion containing ganoderma lucidum spore oil and ganoderan and preparation method and application of oral emulsion
  • Oral emulsion containing ganoderma lucidum spore oil and ganoderan and preparation method and application of oral emulsion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Embodiment 1: Investigate the prescription quantity of the oral emulsion comprising ganoderma spore oil and ganoderma polysaccharide

[0050] The preparation method of the oral emulsion comprising Ganoderma lucidum spore oil and Ganoderma lucidum polysaccharide is as follows:

[0051] 1. Preparation of the oil phase: Mix Ganoderma lucidum spore oil, soybean oil, phospholipid, and propylene glycol oil phase components evenly under nitrogen protection, and set aside.

[0052] 2. Preparation of water phase: dissolving Ganoderma lucidum polysaccharide in an appropriate amount of sterile water to form a uniform aqueous solution for later use.

[0053] 3. Preparation of emulsion: under the protection of nitrogen, the water phase containing Ganoderma lucidum polysaccharide is added to the oil phase by stirring and vortexing, vigorously stirred to form an oil-in-water emulsion, and the emulsion is prepared by high shear;

[0054] 4. Homogeneous emulsification: Repeated homogen...

Embodiment 2

[0060] Example 2: Preparation of oral emulsions comprising Ganoderma lucidum spore oil and Ganoderma lucidum polysaccharide in different proportions

[0061] Using the preparation method of Example 1, the oral emulsion containing Ganoderma lucidum spore oil and Ganoderma lucidum polysaccharide was prepared according to the amount of each component in Table 2 below.

[0062] Table 2

[0063]

[0064] The oral liquid prepared according to the prescription components in Table 2 has good stability, and the average droplet size of the dairy product is less than 0.5 μm.

Embodiment 3

[0065] Example 3: Screening the ratio of Ganoderma lucidum spore oil and Ganoderma lucidum polysaccharide by pharmacokinetic experiment

[0066] 1. Experimental animals

[0067] Experimental animals: male Wistar rats, weighing 260-280 g.

[0068] 2. The present embodiment is divided into 5 experimental groups: the dosage and administration route of each group are as follows:

[0069] (1) Ganoderma lucidum spore oil oral emulsion group (control group): Take 100g of Ganoderma lucidum spore oil, 200g of soybean oil, 60g of phospholipids, 50g of propylene glycol and 6g of citric acid fatty acid glycerides, mix well under nitrogen protection, add 1000mL of blank water phase Emulsification, repeated homogenization and emulsification by a high-pressure homogenizer to prepare an oral emulsion with a particle size of less than 500nm; the dosage of Ganoderma lucidum spore oil is 300mg / kg.

[0070] (2) Oral emulsion group (preparation 1-4) comprising Ganoderma lucidum spore oil and Gan...

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Abstract

The invention discloses oral emulsion containing ganoderma lucidum spore oil and ganoderan and a preparation method and application of the oral emulsion. The oral emulsion comprises, by mass, 1-50% ofthe ganoderma lucidum spore oil, 1-50% of ganoderan, 0.2-10% of an emulsifier, 0-40% of other medicines and food acceptable raw auxiliary materials and 1-97.8% of sterile water. The oral emulsion canbe used for effectively promoting the common absorption of ganoderan and lipid-soluble compounds such as ganoderma triterpenes in the ganoderma lucidum spore oil, and achieves a synergistic effect.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and relates to an oral emulsion containing ganoderma lucidum spore oil and ganoderma polysaccharide, a preparation method and application thereof. The oral emulsion of the invention can promote the oral absorption of active components of the ganoderma lucidum, exert the synergistic effect of the ganoderma spore oil and the ganoderma polysaccharide, and improve the curative effect. Background technique [0002] Immunity is the body's ability to recognize and eliminate foreign intruding foreign bodies (viruses, bacteria, etc.), deal with aging, damaged, and dead self-cells, and recognize and deal with mutant cells and virus-infected cells in the body. The body with low immunity is prone to infections such as bacteria and viruses or suffers from cancer. Excessive immunity can also cause allergies and autoimmune system diseases. In addition, recent studies have shown that fatigue and chro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K47/44A61K36/074A61K31/715A61P37/02A61P39/00
CPCA61K9/0053A61K9/1075A61K31/715A61K36/074A61K47/44A61P37/02A61P39/00A61K2300/00
Inventor 甘勇张馨欣王晓丽缪云秋朱春柳郭仕艳
Owner SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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