Preparation method of cimicifuga foetida-kudzu vine root formula granule

A technology of Cimicifuga Puerariae and formula granules, which is applied in the direction of medical formulas, medical preparations containing active ingredients, plant raw materials, etc., can solve the problems of uneven quality and uneven quality of Cimicifuga Puerariae granules, and achieve standardized and reasonable methods. The effect of high content and uniform granule

Inactive Publication Date: 2019-04-30
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The quality of the existing Cimicifuga Puerariae Granules varies from good to bad, and the quality is not uniform enough. Therefore, it is very necessary to make the preparation method of Cimicifuga Puerariae Granules standardized, reasonable and suitable for large-scale production.

Method used

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  • Preparation method of cimicifuga foetida-kudzu vine root formula granule
  • Preparation method of cimicifuga foetida-kudzu vine root formula granule
  • Preparation method of cimicifuga foetida-kudzu vine root formula granule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1 preparation method of the present invention

[0028] 1. Weigh 40g Cimicifuga, 60g Pueraria Radix, 40g Radix Paeoniae Alba, and 40g Radix Glycyrrhizae for the experiment. Use an electronic balance to weigh the medicinal materials separately, and the amount of the medicinal materials weighed does not exceed 0.3g of the prescribed medicinal materials. Each group of medicinal materials is combined and packed into sealed bags for future use. In this experiment, the Radix Paeoniae Alba needs to be crushed with a crusher so that it can be put into a round bottom flask for water extraction.

[0029] 2. Take out the pre-experimented medicinal materials in the sealed bag, add them to the round bottom flask, and carry out water extraction in the electric furnace. Use 10 times the amount of water for the first time, soak for 30 minutes, decoct with slow fire for 90 minutes after decoction, filter the above decoction in the same way for the second time, combine the two...

experiment example 1

[0033] Experimental example 1 preparation method screening of the present invention

[0034] 1. Take the extraction time and the multiple of the solvent amount as factors, each factor selects 5 levels to test, and take the extraction extract rate, isoferulic acid and puerarin content as evaluation indicators, and all the other conditions are the same as in Example 1. See the table below for the factor levels.

[0035] Table 1

[0036]

[0037] experimental group design

[0038] Experimental grouping design form, as follows

[0039] Table 2

[0040]

[0041]

[0042] X1 represents the extraction time; X2 represents the amount of solvent

[0043] The prescription quantity table of each group of medicinal materials is as follows

[0044] table 3

[0045]

[0046] The mass error of each medicine shall not exceed 0.3g

[0047] 2. Experimental steps and methods

[0048] The experiment was divided into 9 groups, and each experiment was carried out according to the...

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Abstract

The invention relates to a preparation method of a cimicifuga foetida-kudzu vine root formula granule. The preparation method comprises following steps: (a) weighing following raw materials in parts by weight: 40 parts of cimicifuga foetida, 60 parts of kudzu vine root, 40 parts of white peony root, and 40 parts of honey fried licorice root; (b) adding water into raw materials, carrying out extraction for two times, merging the filtrates, and concentrating merged filtrate; (c) adding ethanol into the concentrate to carry out precipitation, and concentrating the supernate to obtain light paste;(d) adding water into the light paste, stirring, sealing, allowing the system to stand still, and carrying out concentration to obtain thick paste; and (e) adding auxiliary materials, evenly mixing,carrying out granulation, sieving, finishing, and charging. The preparation method is reasonable and standard, the prepared granules are uniform, the contents of puerarin and isoferulic acid are high,the quality is effectively guaranteed, and the technology is definite and is suitable for large scale production.

Description

technical field [0001] The invention relates to a preparation method of Cimicifuga puerariae formula granules. Background technique [0002] Cimicifuga Gegen Decoction, also known as Shengma Powder, Cimicifuga Decoction, Siwei Cimicifuga Gegen Soup, Pingxue Drink, Jieji Decoction, Pueraria Cimicifuga Decoction, Gegen Soup, Cimicifuga Drink, Dry Getang, Four Flavors Dry Gegen Soup . From "Taiping Huimin Heji Bureau Prescription". Cure mainly: measles at the beginning. Rash does not come out, fever and headache, cough, red eyes and tears, thirst, red tongue, thin and dry fur, floating and rapid pulse. [0003] Due to the large dosage of traditional Chinese medicine decoctions, it is not conducive to the treatment of many diseases, and its chemical components may cause volatilization and other effects during the decoction process, thereby reducing the clinical efficacy. [0004] Granules refer to dry granule preparations with a certain particle size made of drugs and suitab...

Claims

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Application Information

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IPC IPC(8): A61K36/71A61K9/16A61P31/14
CPCA61K9/1652A61K36/484A61K36/488A61K36/65A61K36/71A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61P31/14A61K2300/00
Inventor廖婉傅超美谭瑾高天慧傅舒邓晶晶赵萱刘芳郑勇凤高飞王胜鹏
OwnerCHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE