30 results about "Method screening" patented technology

The invention discloses an ICU patient abnormity identification method based on video monitoring, and relates to the technical field of video monitoring, and the method comprises the steps: collecting historical data, building a standard set and a habit feature set according to the collected historical data, and generating a prediction set based on the standard set and the habit feature set; collecting real-time data, comparing the real-time data with the standard set, the habit feature set and the prediction set to obtain an abnormal coefficient of the data, calculating a comprehensive danger coefficient according to the abnormal coefficient of the data, and triggering early warning based on the comprehensive danger coefficient; a plurality of disease types of a patient are collected in real time, one disease type is screened out through a two-stage recognition method, the danger degree of the patient is quantified through calculation of a comprehensive danger coefficient, visual decision support is provided for medical staff, and the judgment accuracy is improved through comparative analysis of a standard set, a habit feature set and a prediction set.

The invention discloses a photovoltaic micro-grid grid-connected synchronous control method based on Beidou time service, and relates to the technical field of power system synchronous control, and the method specifically comprises the steps: building a unified time reference of a whole system, calibrating node time through Beidou time service, setting a multi-mode data collection method for multi-mode type data, and screening effective data. A deviation range and a grid-connected state label are set; influences of voltage, frequency and phase deviation on grid-connected instability are quantified through mutual information entropy; a deviation contribution degree coefficient and a risk correction factor are calculated; a core feature is extracted; the method comprises the following steps: constructing Beidou time sequence fingerprints, calculating the similarity between the current Beidou time sequence fingerprints and a fingerprint sample library in real time, screening high-similarity samples to extract strategy elements, selecting an optimal control combination through multi-objective optimization, and adjusting output through information interaction between nodes to realize collaborative optimization.

Described herein are methods such as multi-omic methods for assessing a disease such as cancer. The multi-omic methods may integrate proteomic, transcriptomic, genomic, lipidomic, or metabolomic data. The method screening diseases or disease states. Also described herein are methods for screening for diseases or disease states from biological samples. The methods may include assessing whether a nodule, mass, or cyst is cancerous.

The invention develops a sarcopenia prediction system for an adult group. The sarcopenia prediction method comprises the following steps: determining a crowd range and a standard included in the prediction system; determining a sarcopenia diagnosis standard and collecting outcomes in the target population; selecting a tree-based machine learning model according to the data features; screening the features by using a Boruta algorithm to construct a first set of screening model with high recall rate; screening features by using a pre-SHAP analysis method to construct a second set of auxiliary models for balancing the recall rate and the accuracy rate; optimal models of the system are determined by comparing model performance parameters, and finally prediction is achieved by combining the models. Features used by the system only depend on basic demographic features and physical activity questionnaires without clinical indexes, meanwhile, high performance is achieved in a model parallel connection mode, and the system is suitable for early screening detection of sarcopenia.

This disclosure provides a model training method, a standard output selection method, a selection method, and an apparatus. It relates to the fields of Internet of Things (IoT) and artificial intelligence (AI). The model training method includes: acquiring target hard drive attribute information, wherein the target hard drive satisfies a target selection threshold, the target selection threshold including a threshold defined for at least one hard drive attribute information of the target hard drive; acquiring a first hard drive attribute expectation value defined for the target hard drive by a first service, wherein the first service has first service type information; inputting the target hard drive attribute information, the first service type information, and the first hard drive attribute expectation value into a prediction model to be trained to obtain a prediction selection threshold, wherein the prediction selection threshold is used when the target hard drive is applied to the first service; and training the prediction model using the target selection threshold and the prediction selection threshold.

The invention relates to the technical field of microbial screening, in particular to a method for high-throughput screening of flavone-transformed bacteria and a screening system thereof. The method comprises the following steps: firstly, inoculating a to-be-detected strain into a basal culture medium containing a flavone substrate for fermentation, then scanning fermentation broth at two different time points by using a full-wavelength microplate reader through a quartz microplate, calculating an absorbance difference value at at least one preset wavelength, and finally, calculating the absorbance difference value at least one preset wavelength. The strains with the absorbance difference larger than a preset threshold value are screened as primary screening positive strains. Compared with the traditional technology, the method has the advantages that the screening efficiency is improved by hundreds of times, the sample consumption is reduced by 75%, the industrial bottleneck that multi-structure flavonoids need to be repeatedly developed is broken through, and an innovative tool is provided for microbial resource development.

The invention discloses a sensitizing drug for resisting breast cancer by radiotherapy and a screening method and application thereof, and belongs to the field of biomedicine.The method comprises the steps that an in-vitro radiotherapy resistance model is constructed, a clinical segmentation radiotherapy dose increasing mode is simulated, stable acquired radiotherapy resistance is induced to be generated, and a carrier is provided for drug screening; natural plant small molecule compounds are used for treatment, and through concentration and time gradient dual control, the reversion ability of the natural plant small molecule compounds to radiotherapy resistance phenotypes is investigated; a multi-dimensional joint detection system is established, multi-level comprehensive evaluation is performed from cell survival and the like, the limitation of a single index is broken through, and the screening accuracy and reliability are improved; dNA damage repair is dynamically monitored through immunofluorescence, comet electrophoresis and the like, and the drug action mechanism is revealed. The medicine screened by the method is suitable for primary and acquired radiotherapy resistance patients, can effectively improve the radiotherapy curative effect, provides a new medicine source and scheme for clinical problems, and opens up the application of the compound in preparation of radiosensitizers or adjuvant therapy medicines.

This method includes a step of performing a whole genome analysis of the bacteria contained in the sample; and a step of comparing the base sequence of the obtained whole genome with the base sequence of SEQ ID NO: 1 or 2, and determining whether the bacteria in the sample are pan-resistant K. pneumoniae based on the degree of match.

The invention provides a medical clinical data processing method and system, computer equipment and a medium, and belongs to the field of medical data processing.The medical clinical data processing method includes the steps that demographic statistics features, lifestyle features, biochemical index features, physical examination result features and disease history features are extracted from a CHARLS data set, and an original feature set is constructed; randomly disrupting feature values of the original feature set, and constructing corresponding shadow features; importance scores are calculated, and significance features are determined according to the original feature set with the importance scores larger than the maximum value of the importance scores of the shadow features; and training an XGBoost model by taking the saliency characteristics as input and taking the risk probability of the ADL disability as output to obtain a prediction model capable of predicting the risk probability of the ADL disability. The saliency features screened by the method inevitably have non-linear strong correlation with the health result, the model obtained through training can assist doctors in health state diagnosis, and the problem that the extracted features are low in effectiveness when an existing model faces data related to sarcopenia is avoided.

The application discloses a generator set artificial intelligence system machine learning sample screening method and device, obtains generator set operation data, adopts a preset cleaning method for one or more times of data cleaning on the generator set operation data, obtains a candidate sample set and an invalid sample set, if multiple times of data cleaning are adopted, different cleaning methods are adopted for each time of data cleaning, sorts the candidate sample set by adopting a preset sorting method, obtains a sorted sample set, extracts the sorted sample set according to a preset extraction method, obtains a learning sample subset, repeats the previous step for multiple times, adopts different sorting methods and the same or different extraction methods each time, extracts different learning sample subsets, and combines all the learning sample subsets into a learning sample set. The method is used for screening the generator artificial intelligence system machine learning sample, has low requirements on the professional quality of an operator, has high automation degree in a processing process, and has good extensive distribution of the screened learning sample.

To provide a dispersibility evaluation method, a screening method and a dispersibility prediction method of a dispersion system having three components of a powder, a dispersant and a dispersion medium as constituent components, and to provide a system capable of proposing a combination of the constituent components having high dispersibility.SOLUTION: One constituent component is specified from a powder, a dispersion medium, and a dispersant which are constituent components of a dispersion system, and then, with respect to a dispersant-treated powder obtained by surface-treating a powder with a dispersant in advance and an untreated powder for a plurality of constituent components, a mean particle diameter in a dispersion obtained by mixing each of the powders with the dispersion medium is measured, the suitability of each constituent component is determined according to a parameter based on the mean particle diameter, and a Hansen sphere forming a boundary between the two is obtained. The dispersibility is evaluated based on the distance between the center position coordinate of the Hansen sphere and the position coordinate of the Hansen solubility parameter of the specific component to be evaluated.SELECTED DRAWING: Figure 2

The invention discloses a transportation method and system for garment processing based on Internet of Things control, and relates to the technical field of Internet of Things control. Transportation environment data is collected and preprocessed; the environment position data, the AGV position data and the transportation target data are defined as nodes, node path edges are defined according to the distance between the nodes, and a three-dimensional communication topological graph is generated; determining a transportation path of the AGV from the initial position to the transportation target position according to the path edge weight in the three-dimensional communication topological graph, and generating an AGV transportation instruction; an AGV transportation instruction is executed, electromagnetic interference and physical obstacles of a transportation path are monitored, and bimodal obstacle avoidance is carried out on the electromagnetic interference and the physical obstacles; and after the bimodal obstacle avoidance is completed, measuring the three-dimensional space deviation between the actual arrival position and the target position of the AGV, and outputting a clothing adjustment measure. According to the method, the transportation path is screened by constructing the three-dimensional communication topological graph and the DFS method, and accurate transportation of the garment materials in the interference environment is achieved.

A multilevel sensitivity analysis method for nuclear power plant main steam system model parameters based on Morris and GLUE comprises the steps that a main steam system model is operated, and parameter-observed quantity data pairs are generated through the model; screening out main parameters which have obvious influence on the output of the main steam system model through a Morri method; generating a plurality of groups of parameters in a parameter prior distribution range by adopting LHS, and performing GLUE method calculation; the convergence of the Morri method and the GLUE method is analyzed by calculating the Pearson's correlation coefficient, the KL divergence and the divergence difference delta KL; the method comprises the following steps: determining modeling parameters having significant influence on the output of a main steam system model, finding most sensitive key parameters by using a DBSCAN clustering method, evaluating the efficiency improvement performance of the main steam system model, and verifying the efficiency improvement effect during multilevel sensitivity analysis by comparing original calculation dimensions and calculating required time. According to the method, sensitivity analysis is performed on the model parameters of the main steam system of the nuclear power plant, the search space of parameter tuning is optimized, and the model optimization efficiency is improved.

The application belongs to the field of pharmaceutical analysis, and particularly relates to a method for establishing a traditional Chinese medicine fingerprint spectrum of Gastrodia and Uncaria Decoction. The method is realized through the following steps: firstly, preparing a reference solution and a sample solution, and then detecting by using high performance liquid chromatography to establish the fingerprint spectrum. The method provided by the application can effectively represent the change of the component quantity among samples by reasonably selecting the reference component and using the multi-wavelength method according to the maximum absorption wavelength of the component, so that the quality of the sample can be more accurately judged. The application further provides a preparation method screening and optimization method of Gastrodia and Uncaria Decoction, the prepared method has good repeatability and stability, and can more comprehensively monitor the quality of Gastrodia and Uncaria Decoction, and the method provides a valuable reference for the quality evaluation and standardization of traditional Chinese medicine decoction.

The invention relates to the field of resume data analysis systems, in particular to a talent feature extraction system and method based on resume data analysis, and aims to solve the problem that screening logic of the talent feature extraction system and method based on resume data analysis excessively depends on educational background indexes. Educational background weight setting is fixed and cannot be flexibly adjusted according to differentiated requirements of different posts for educational background; the problems that deep mining and quantitative evaluation of non-educational core features are lacked, and educational difference is difficult to make up through dimensions such as skill proficiency, work achievements and growth potential are solved; by setting a multi-mode educational background screening function and a characteristic weight self-defined adjusting mechanism, the most important rigid screening logic of an existing system educational background is broken through, candidates which do not reach the target educational background but have the capability reaching the standard are not directly screened out in a flexible mode, the situation that high-quality talents are missed due to limitation of the fixed educational background is effectively avoided, and the reliability of the system is improved. And the inclusiveness of talent selection is improved.

The invention relates to the technical field of pharmaceutical chemistry and bioinformatics, in particular to a drug molecular structure three-dimensional modeling and optimization processing method, which comprises the following steps: constructing a three-dimensional virtual space containing a pathogen and a drug agent; setting a connection logic based on distance and energy, so that the drug agents are self-assembled to form molecular clusters when meeting conditions; dynamic simulation is operated, and molecular clusters are driven to form space surrounding on the surface of the pathogen; calculating the surface coverage rate of the cluster to the pathogen key sites and generating a fitness score; and carrying out updating such as hydrophobic modification and the like on the drug molecule topological structure based on the score by utilizing an evolutionary algorithm, and iteratively generating an optimal structure. According to the method, a multi-agent cooperation mechanism is introduced into a calculation model, and drug self-assembly and virus space encirclement are incorporated into screening indexes, so that the method can discover a novel drug structure for physically blocking virus infection by forming a large-volume cluster, and the problem of screening leakage in a traditional method is effectively solved.

Described herein are methods such as multi-omics methods for assessing a disease. The multi-omics methods may integrate proteomic, transcriptomic, genomic, lipidomic, or metabolomic data. The method screening diseases or disease states. Also described herein are methods for screening for diseases or disease states from biological samples. Also described herein are multi-omics databases and methods of using them.

The application relates to the technical field of medical academic digital popularization, and specifically discloses an intelligent communication auxiliary method and system for medical academic popularization, which comprises the following steps: acquiring multi-source communication data and analyzing and extracting business characteristics, constructing a cooperation partner portrait, converting the portrait and business project demand into a semantic vector, calculating the similarity to screen a candidate cooperation partner set, calculating the score through a comprehensive scoring function, generating a cooperation partner recommendation list, real-time identification of compliance risks in business communication and pushing prompt information, automatic generation of targeted popularization language, collection of business feedback data for dynamic adjustment of the weight coefficient of the scoring function. Through the closed-loop mechanism of multi-source data fusion, semantic matching, comprehensive scoring, compliance control and dynamic optimization, the application solves the problems of low screening efficiency, insufficient matching accuracy, high labor cost and high compliance risk of traditional methods, improves the business efficiency and communication quality of medical academic popularization, reduces the compliance risk, and realizes the intelligentization of the whole popularization process.

The invention relates to the technical field of data processing, in particular to a digital biomarker tracking method. The method comprises the following steps: acquiring a reaction image of the combination of a biomarker and a reagent, transmitting the image to a server, screening and removing outliers in the image by utilizing a statistical method, carrying out preliminary correction by adopting a least square method, and finishing secondary correction by combining an image algorithm. Reaction areas are extracted through image segmentation, background and irrelevant areas are eliminated, chemical reaction background noise is deducted, and reagent attenuation influences are corrected. And establishing a reaction intensity function by adopting infinite series expansion based on the preprocessed image features, and fitting a biomarker concentration sign curve through a linear regression model in combination with a historical database. Meteorological data are obtained through GPS positioning and an environment sensor, and dynamic environment compensation of the regression model is achieved. And finally, the detection result is compared with the feature database, and a personalized detection report is generated and sent to the user.

The application belongs to the field of pharmaceutical analysis, and particularly relates to a method for establishing a traditional Chinese medicine fingerprint of postoperative ventilation decoction. The method is realized through the following steps: firstly, preparing a control solution and a test solution, and then detecting by using high performance liquid chromatography to establish the fingerprint. The method provided by the application can effectively represent the change of the component quantity between samples by reasonably selecting the control component and adopting the method of fixed wavelength according to the maximum absorption wavelength of the component, so that the quality of the sample can be more accurately judged. The application further provides a preparation method screening and optimization method of the postoperative ventilation decoction. The prepared method has good repeatability and stability, and can more comprehensively monitor the quality of the postoperative ventilation decoction. The method provides a valuable reference for the quality evaluation and standardization of traditional Chinese medicine decoction.

The application provides a construction method of a pig YBX3 gene knockout cell line, and is characterized by comprising the following steps: S1, designing sgRNA guide sequences, respectively sgRNA1, sgRNA2 and sgRNA3; S2, adding additional base CACC at the 5' end; S3, positively knocking out the plasmid mixture and performing drug screening by electric transformation, extracting YBX3 knockout cell DNA, using T7Endonuclease I enzyme to cut the PCR product, and simultaneously performing PCR amplification sequencing to verify the sgRNA efficiency; S4, selecting IPEC-J2 with high efficiency sgRNA transfection to perform limited dilution method screening; and S5, detecting the expression difference of PEDV M gene by RT-qPCR. The application successfully establishes the IPEC-J2 cell line with the pig YBX3 gene knockout, and the CRISPR / Cas9 knockout technology is more effective than interference, gene silencing and other technical means, and can help to study the function of YBX3 in pig disease resistance breeding.

The present application relates to the technical field of medicinal chemistry and bioinformatics, in particular to a kind of drug molecular structure three-dimensional modeling and optimization processing method, steps include: construct the three-dimensional virtual space including pathogen and drug intelligent agent;Set up the connection logic based on distance and energy, so that drug intelligent agent is self-assembled to form molecular cluster when meeting the condition;Run dynamics simulation, drive molecular cluster to form spatial encirclement on the surface of pathogen;Calculate the surface coverage of cluster to key site of pathogen and generate fitness score;Based on score, update the hydrophobicity modification of drug molecular topological structure using evolutionary algorithm, and iteratively generate optimal structure.The present application introduces multi-agent collaborative mechanism in the calculation model, and includes drug self-assembly and virus spatial encirclement into screening index, so that the method can find new drug structure by forming large volume cluster to physically block virus infection, effectively solve the problem of traditional method screening.

A production method of a nucleic acid display library, including producing a nucleic acid-polypeptide conjugate by expressing a polypeptide from a nucleic acid and linking the nucleic acid to the polypeptide, in which a modification molecule may or may not be present in the nucleic acid-polypeptide conjugate and separating the nucleic acid-polypeptide conjugate from a mixture of a polypeptide not linked to the nucleic acid and the nucleic acid-polypeptide conjugate, independently of a nucleotide sequence of the nucleic acid and the modification molecule; and a screening method and a production method of a polypeptide, in which the nucleic acid display library is used.

The invention belongs to the technical field of bioinformatics, and particularly relates to a specific sequence hierarchical database and a construction method thereof, and a method and a device for screening specific sequences. The invention provides a construction method of a specific sequence classification database. The construction method comprises the following steps: constructing a K-mer specific classification level database, and screening specific genome sequences of target classification levels by adopting the database. After the K-mer specificity classification level database is established, the K-mer specificity classification level database can be repeatedly used in subsequent steps. The step of acquiring the sequence of the target specificity classification level by using the database can be automatically operated through a program, and the operation speed is high.

The invention relates to a code generation method and device, computer equipment, a storage medium and a product. The method comprises the steps of screening an initial function set matched with a development demand from a function database based on the development demand of a to-be-developed code; the function database comprises corresponding relations between various development requirements and functions; according to the information database, screening out a target function set with calling logic meeting development requirements from the initial function set; the information database comprises a corresponding relation between a plurality of functions and calling logics; performing information extraction on parameters of the target function set according to a parameter database to obtain a target parameter set; the parameter database comprises a corresponding relationship between a plurality of functions and a parameter set; and generating a to-be-developed code based on the target function set and the target parameter set. According to the method, the target function set and the parameter function set meeting the development requirements are screened and then integrated according to the development requirements, the codes meeting the development requirements are generated, and the quality of the codes is improved.

The invention records a risk prediction method for severe herpes zoster of a tumor patient, and the method comprises the following steps: constructing a scoring system to score the severity of the herpes zoster, and defining the severe outcome of the herpes zoster; constructing an original data set based on medical data of a certain sample size of tumor patients who are diagnosed after herpes zoster attack; constructing a minimum absolute contraction and selection operator (LASSO) regression model, namely introducing a norm penalty term on the basis of a logistic regression model, performing feature screening on data in the original data set, and outputting a core predictive variable; constructing an original multi-factor Logistic regression prediction model by taking the core prediction variable as an independent variable and taking a critical outcome as a dependent variable; and carrying out recalibration on the original multi-factor Logistic regression prediction model. According to the method, a core prediction index is screened and determined, a risk prediction model for severe herpes zoster is established, the coefficient and intercept of each prediction variable are clarified, and the method has excellent distinguishing capability and good calibration performance.

Described herein are methods such as multi-omic methods for assessing a disease such as cancer. The multi-omic methods may integrate proteomic, transcriptomic, genomic, lipidomic, or metabolomic data. The method screening diseases or disease states. Also described herein are methods for screening for diseases or disease states from biological samples. The methods may include assessing whether a nodule, mass, or cyst is cancerous.

The application relates to a code generation method and device, computer equipment, a storage medium and a product. The method comprises the following steps: based on a development requirement of to-be-developed code, an initial function set matched with the development requirement is screened from a function database; the function database comprises a corresponding relationship between a plurality of development requirements and functions; according to an information database, a target function set with calling logic meeting the development requirement is screened from the initial function set; the information database comprises a corresponding relationship between a plurality of functions and calling logic; information extraction is performed on parameters of the target function set according to a parameter database, and a target parameter set is obtained; the parameter database comprises a corresponding relationship between a plurality of functions and parameter sets; and based on the target function set and the target parameter set, to-be-developed code is generated. According to the method, the target function set and the parameter function set meeting the development requirement are screened, and then the code meeting the development requirement is generated by integration according to the development requirement, so that the quality of the code is improved.

The method for screening the marker of the target microorganism, the screened marker and the detection probe group thereof can quickly, accurately, highly sensitively and highly specifically target and detect the target microorganism. Compared with the prior art, the method has stronger target specificity for pathogen detection, is less affected by human nucleic acid, can effectively reduce host background noise, has a more optimal signal-to-noise ratio for low-load nucleic acid detection, is beneficial to improve the detection positive rate. Moreover, the required data quantity for sequencing is effectively reduced, and the sequencing cost is greatly reduced.

A method for controlling the operation of a screening apparatus, comprising: a step (i) of supplying powder (56) to be screened onto a screener through a powder inlet (22); and step (ii) driving the filter at a first driving power for a first period of time, the first driving power being sized such that during continuous driving of the filter at the first driving power, the powder (56) to be screened flows across the entire screening surface of the filter and / or into the oversized particle outlet (32). After the first period of time has elapsed, in step (iii), the filter is driven at a second drive power lower than the first drive power for a second period of time. After the second period of time has elapsed, steps (ii) and (iii) are repeated.