Optical coherence tomography method and apparatus based on indocyanine green

Abstract

The invention relates to an optical coherence tomography method and apparatus based on indocyanine green. The optical coherence tomography method includes the steps: the same amount of phospholipid-polyethylene glycol and the indocyanine green are taken at room temperature and added to distilled water correspondingly to be prepared into solutions, then the two solutions are mixed according to themass ratio of the indocyanine green to the phospholipid-polyethylene glycol being 1:20, and an indocyanine green contrast agent is obtained; the indocyanine green contrast agent is injected into an imaging target, and the indocyanine green contrast agent permeates freely within the imaging target; and an OCT imaging system is opened to obtain images with the depth range produced by OCT imaging ofthe imaging target. According to the optical coherence tomography method and apparatus based on the indocyanine green, the indocyanine green contrast agent based on nanomaterials is used, the effect of optical coherence tomography on image reconstruction of the imaging target is very obvious, the high longitudinal resolution is achieved, the imaging ability is very strong, and the detection response is rapid.

Description

technical field [0001] The invention belongs to the field of biological image detection, and in particular relates to an indocyanine green-based optical coherence tomography method and device. Background technique [0002] Optical coherence tomography (OCT) is a new tomographic imaging technology after X-ray, CT and magnetic resonance imaging. Optical coherence tomography is mainly used to image biological tissues with complex structures, such as skin and liver. It can detect the tissue microstructure at a depth of 2 to 3 mm on the surface of living tissues in vivo, and realize three-dimensional structural imaging. In recent years, frequency-domain OCT imaging technology has been widely used in the diagnosis of skin diseases, early diagnosis of tumors, and diagnosis of dental surgery diseases. However, there are still some deficiencies in the optical coherence tomography system for biological imaging. Taking the diagnosis of tumor as an example, since the components of tum...

AI Technical Summary

Problems solved by technology

However, there are still a series of physical and chemical properties that are not conducive to practical application in the use of ICG, such as concentration-dependent aggregation, poor stability, non-specific protein binding and lack of targeting, and its half-life in vivo is 2-4min Very unfavorable for accumulation in the tumor area

These defects greatly limit the clinical application of ICG

Images