The invention discloses a reinforcement method of TRC for improving an anti-seismic performance of multi-piece brick masonry wall, and belongs to the technical field of repair, reinforcement and construction of masonry walls. The reinforcement method comprises the steps that a plurality of penetrating circular holes are drilled in the wall to be reinforced, and fiber reinforced plastic (FRP) rib anchor rods are used for penetrating through the circular holes; the surface of the wall to be reinforced is coated with high-performance concrete, a fiber woven net is impregnated with epoxy resin, and the surface of the fiber woven net is coated with the high-performance concrete again; If one layer of fiber woven net can not meet the requirement of wall anti-seismic performance improvement, twoor more layers of fiber woven nets can be laid; and wet water curing is carried out until the high-performance concrete age is reached. According to the reinforcement method of TRC for improving the anti-seismic performance of the multi-piece brick masonry wall, in-plane shear resistance and out-of-plane bending resistance of the multi-piece brick masonry wall are improved, the risk of serious damage or even collapse of a masonry structure in earthquake is reduced, the inadaptability of a masonry material caused by the use of the epoxy resin in FRP reinforcement is avoided, deficiency of low reinforcement efficiency of engineered cementitious composite (ECC) reinforcement is effectively improved, and the integrity of multi-piece brick masonry wall is improved.