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Medical use of amine compound in treating pain

A technology of amine compounds and uses, applied in the field of amine compounds for the preparation of drugs for the prevention and/or treatment of pain, capable of solving central sedation adverse reactions, respiratory depression, cardiotoxicity and other problems

Pending Publication Date: 2019-05-17
CSPC ZHONGQI PHARM TECH (SHIJIAZHUANG) CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Opioid analgesics have strong analgesic effects, but long-term use can easily lead to tolerance, dependence, and addiction, and have adverse reactions such as respiratory depression and central sedation. They are currently used for acute sharp pain and severe cancer pain.
Non-steroidal anti-inflammatory drugs only exert a moderate degree of analgesic effect and are suitable for mild and moderate chronic dull pain, but are ineffective for sharp pain caused by direct stimulation of sensory extremities. In addition, they also have adverse reactions such as gastrointestinal bleeding and cardiotoxicity

Method used

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  • Medical use of amine compound in treating pain
  • Medical use of amine compound in treating pain
  • Medical use of amine compound in treating pain

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Example 1. Evaluation of the analgesic effect of 071031B by mouse acetic acid writhing method

[0054] 1. Experimental animals:

[0055] KM mouse, male, SPF grade, 22-25g,

[0056] The animals were purchased from the Experimental Animal Center of the Academy of Military Medical Sciences and bred in the Experimental Animal Center of the Academy of Military Medical Sciences.

[0057] 2. Test sample:

Embodiment 2

[0058] 071031B, its structural formula is Prepared according to the method of Example 2 of the patent application CN101613347A;

[0059] Duloxetine hydrochloride (Zhejiang Haixiang Pharmaceutical Co., Ltd.).

[0060] 3. Experimental method:

[0061] After oral administration of test drug 071031B or positive drug duloxetine in mice for 30 minutes, each mouse was intraperitoneally injected with 2% acetic acid aqueous solution 0.1ml / 10g, and the number of times of writhing of each mouse in 5-20 minutes was observed and recorded, namely The body twisting or elongation of the mouse with concave abdomen was counted as one writhing response. Compared with the control group, if the number of writhing reactions decreases, it means that there is a certain analgesic effect.

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Abstract

The invention relates to medical use of an amine compound, in particular to use of an amine compound represented by a formula I or a pharmaceutically acceptable salt thereof for preventing and / or treating pain. It is proved by experiments that the amine compound represented by the formula I or the pharmaceutically acceptable salt thereof has a strong abirritation effect, and a novel and effectivemedicine is provided for preventing and / or treating pain. The formula I is in the description below.

Description

[0001] This application is a divisional application of the invention patent application with the application number 201410495093.X entitled "The Medical Use of Amine Compounds for Treating Pain" filed on September 25, 2014. technical field [0002] The present invention relates to the medical use of amine compounds, in particular to the use of amine compounds for preparing medicines for preventing and / or treating pain. Background technique [0003] Pain is a painful sensation resulting from actual or potential tissue damage, often accompanied by unpleasant emotions or cardiovascular and respiratory changes. It is not only a protective response of the body, but also a common symptom of many clinical diseases. [0004] Depending on the duration, pain can be divided into acute pain and chronic pain. Acute pain is mostly nociceptive pain caused by tissue trauma, while chronic pain is mainly neuropathic pain. Pain has a high clinical incidence and brings great suffering to pati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/381A61P29/00A61P25/00A61P21/00
Inventor 张有志仲伯华薛瑞张亭亭何新华董华进樊士勇李云峰黄世杰袁莉
Owner CSPC ZHONGQI PHARM TECH (SHIJIAZHUANG) CO LTD
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